NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia

Autor: Xi Wang, Olivia K. Travis, Corbin A. Shields, G. Ann Tardo, Chelsea Giachelli, Christopher W. Nutter, Hannah L. Glenn, Olive G. Cooper, Tatiana Davis, Rashauna Thomas, Jan M. Williams, Denise C. Cornelius

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R556-R567

Preeclampsia (PE) is a pregnancy-specific hypertensive disorder with end-organ damage that presents after 20 wk of gestation. PE pathophysiology often includes vascular dysfunction and increased inflammation that continues to damage patient health ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aa9d818b6d46ebf54083d99713b60b4
https://doi.org/10.1152/ajpregu.00192.2022

Tumor Necrosis Factor-alpha Blockade Improves Uterine Artery Resistance, Maternal Blood Pressure, and Fetal Growth in Placental Ischemic Rats

Autor: Jan M. Williams, Andrea K Brown, Geilda A. Tardo, Tyler Johnson, Chelsea Giachelli, Denise C. Cornelius, Madison T. Crosby, Olivia K. Travis, Shani Siddiq, Henry T. Nguyen

Publikováno v: Pregnancy Hypertens

We recently reported that adoptive transfer of cytolytic Natural Killer cells (cNKs) from the Reduced Uterine Perfusion Pressure (RUPP) rat induces a preeclampsia (PE)-like phenotype in pregnant rats, accompanied by increased TNF-α. The purpose of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5763565112865afbdba057cb414e4e9
https://doi.org/10.1016/j.preghy.2021.05.002

The SS(LepR) mutant rat represents a novel model to study obesity-induced renal injury before puberty

Autor: Bibek Poudel, Corbin A. Shields, Ubong S. Ekperikpe, Andrea K. Brown, Olivia K. Travis, Jordan C. Maury, Sarah Fitzgerald, Stanley V. Smith, Denise C. Cornelius, Jan M. Williams

Publikováno v: Am J Physiol Regul Integr Comp Physiol

Prepubertal obesity (PPO) has emerged as a major health problem over the past few decades and is a risk factor for the development of proteinuria. The current study investigated whether the development of renal injury in the obese SSLepR mutant strai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4948626b212414c1e17edac972a7f
https://europepmc.org/articles/PMC8917907/

Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Kidney Injury

Autor: Chelsea Giachelli, Cedar H. Baik, Olivia K. Travis, Geilda A. Tardo, Marivee Borges-Rodriguez, Corbin A. Shields, Denise C. Cornelius, Jan M. Williams, Robert W. Tramel

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10330, p 10330 (2021)

Platelets, cellular mediators of thrombosis, are activated during sepsis and are increasingly recognized as mediators of the immune response. Platelet activation is significantly increased in sepsis patients compared to ICU control patients. Despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce658e4d680512d793b4abd889115d7a
https://pubmed.ncbi.nlm.nih.gov/34638670

Interferon γ neutralization reduces blood pressure, uterine artery resistance index, and placental oxidative stress in placental ischemic rats

Autor: Madison T. Crosby, Olivia K. Travis, Jan M. Williams, Alex N Smith, Henry T. Nguyen, Geilda A. Tardo, Denise C. Cornelius, Tyler Johnson, George W. Booz, Chelsea Giachelli, Andrea K Brown, Shani Siddiq

Publikováno v: Am J Physiol Regul Integr Comp Physiol

Preeclampsia (PE) is characterized by maternal hypertension, intrauterine growth restriction, and increased cytolytic natural killer cells (cNKs), which secrete interferon γ (IFNγ). However, the precise role of IFNγ in contributing to PE pathophys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a099a63bf43792b3dc43129f6e7a5d55
https://europepmc.org/articles/PMC8409917/