Efficacy and safety of CD24Fc in hospitalised patients with COVID-19: a randomised, double-blind, placebo-controlled, phase 3 study

Autor: James Welker, Juan D Pulido, Andrew T Catanzaro, Carlos D Malvestutto, Zihai Li, Jonathan B Cohen, Eric D Whitman, Dana Byrne, Olivia K Giddings, Jordan E Lake, Joel V Chua, Ella Li, Jian Chen, Xiang Zhou, Kun He, Davis Gates, Amarjot Kaur, Jamie Chen, Hung-Yen Chou, Martin Devenport, Raymond Touomou, Shyamasundaran Kottilil, Yang Liu, Pan Zheng, Jai Thakor, Imaan Khan, Nicole Do, Josephine Faragalla, Andrea Hook, Sarah Kern, Janira V. Ramos, Jason Ward, John Higson, Meena Dam, Dawn Serkin, Pooja Karloopia, Wendy Moore, Mark Scofield, David Jeffery Childers, Jeffrey S. Cantrell, Millie Corgan, Jing Liu, Denise Redvers-Higgins, Hua Han, Jiyun Hou, Yudi Pan, Karyn Tucker, Xiaoyan Zhang, Joel V. Chua, Jennifer Husson, Shivakumar Narayanan, Jaqueline Bran, Ka Wing Joyce Lam, Alicia Jeffrey, Olivia K. Giddings, Jennie Pexa, Mario Becerra, Kathleen W. Gray, Nicole Richmond, Chukwuemeka Nzelibe, Carlos D. Malvestutto, Susan Koletar, Mahdee Sobhanie, Jan Clark, Kelsi Reynolds, Karthik Chakravarthy, Kevin Weller, Mohamed Yusuf, Jennifer Severing, Kelley Barley, Juan D. Pulido, Jennifer C. Fulton, William Gil, M.D. Jeanine, Richmond R.N., Sandy Jones, Kristina Clemmer, Lisa Pedroza, Emily Nicole Davidson, Amanda Logan, Katie Grant, Eric D. Whitman, Jason Kessler, Robert Roland, Rosemary Stefiniw, Molly Maurer, Salome Geene, Christopher F. Buck, Debra Connolly, Patrice Light, Sunanda Baviskar, Yee Won Low, Kyra Michalski, Pamela Giordano, Jennifer Chao, Michelle Williams, Amulya Makkapati, Andrew T. Catanzaro, Jonathan B. Cohen, Mehad Musbah, Pramila Jaladanki, Ying Yuan, Shilpa Rele, Desirae Stewart, Starlet Lewis, Ian Sankar, Nabulungi Kasumba, Kaylia Biney, Elham Hekmat, Jordan E. Lake, Bindu Akkanti, Melissa J. Reimer-McAtee, Marisel Negret Hernandez

Publikováno v: The Lancet. Infectious diseases. 22(5)

Non-antiviral therapeutic options are required for the treatment of hospitalised patients with COVID-19. CD24Fc is an immunomodulator with potential to reduce the exaggerated inflammatory response to tissue injuries. We aimed to evaluate the safety a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6942fc252d729f16df5ccd60b55adb2f
https://pubmed.ncbi.nlm.nih.gov/35286842

Immune responses to gp82 provide protection against mucosal Trypanosoma cruzi infection

Autor: Christopher S Eickhoff, Olivia K Giddings, Nobuko Yoshida, Daniel F Hoft

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 105, Iss 5, Pp 687-691 (2010)

The potential use of the Trypanosoma cruzi metacyclic trypomastigote (MT) stage-specific molecule glycoprotein-82 (gp82) as a vaccine target has not been fully explored. We show that the opsonization of T. cruzi MT with gp82-specific antibody prior t

Externí odkaz: https://doaj.org/article/ddfb399ec0174636b1d795bff898b834

Trans-Sialidase Recombinant Protein Mixed with CpG Motif-Containing Oligodeoxynucleotide Induces Protective Mucosal and Systemic Trypanosoma cruzi Immunity Involving CD8+ CTL and B Cell-Mediated Cross-Priming

Autor: Daniel F. Hoft, Christopher S. Eickhoff, Mauricio M. Rodrigues, Olivia K. Giddings, José Ronnie C Vasconcelos

Publikováno v: The Journal of Immunology. 179:6889-6900

The Trypanosoma cruzi trans-sialidase (TS) is a unique enzyme with neuraminidase and sialic acid transfer activities important for parasite infectivity. The T. cruzi genome contains a large family of TS homologous genes, and it has been suggested tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7268ae099ba55e7f015087a910c11a
https://doi.org/10.4049/jimmunol.179.10.6889

Toxoplasma gondiiUses Sulfated Proteoglycans for Substrate and Host Cell Attachment

Autor: Sebastian Håkansson, Olivia K. Giddings, L. David Sibley, Vern B. Carruthers

Publikováno v: Infection and Immunity. 68:4005-4011

Toxoplasma gondiiis an obligate intracellular parasite that actively invades a wide variety of vertebrate cells, although the basis of this pervasive cell recognition is not understood. We demonstrate here that binding to the substratum and to host c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0911f01e915f705684b07aaa41dc43f
https://doi.org/10.1128/iai.68.7.4005-4011.2000

Treatment With Continuous Positive Airway Pressure Improves Survival In Patients With Idiopathic Pulmonary Fibrosis And Obstructive Sleep Apnea

Autor: Beth Mallow, Hal Collard, James A. Parnell, Lisa Lancaster, Mario Davidson, Wendi R. Mason, Olivia K. Giddings, James E. Loyd

Publikováno v: B93. CLINICAL TRIALS IN IDIOPATHIC PULMONARY FIBROSIS AND SARCOIDOSIS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35f66e86c3025c03a804a1c2c32a415d
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3637