Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Olivia J. White"'
Autor:
Antonia L Pritchard, Olivia J White, Julie G Burel, Melanie L Carroll, Simon Phipps, John W Upham
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106501 (2014)
BackgroundHuman rhinovirus (HRV) infection is a major trigger for asthma exacerbations. Anti-viral immunity appears to be abnormal in asthma, with immune dysfunction reported in both airway structural cells and migratory, bone marrow derived cells. T
Externí odkaz:
https://doaj.org/article/929754f8165d42e79fa4ddf8cbc1260a
Autor:
Tracy S P Heng, Jessica J Reiseger, Anne L Fletcher, Graham R Leggatt, Olivia J White, Katerina Vlahos, Ian H Frazer, Stephen J Turner, Richard L Boyd
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42677 (2012)
Recent evidence suggests that the decline in resistance to viral infections with age occurs predominantly as a result of a gradual loss of naïve antigen-specific T cells. As such, restoration of the naïve T cell repertoire to levels seen in young h
Externí odkaz:
https://doaj.org/article/6ccc72faf0e24016aa1b38383c2a285d
Autor:
Anita H. J. van den Biggelaar, Patrick G. Holt, Olivia J. White, Peter McIntyre, Nicholas DeKlerk, Peter D. Sly, Jonathan R. Carapetis, Michael Gold, Tom Snelling, Nicholas Wood
Publikováno v:
Vaccine. 34:4257-4262
Background Several previous studies have highlighted the strong Th2-polarising and IgE-promoting activity of the DTaP vaccine, but there is no evidence that this has pathological consequences and accordingly there is no current interest amongst vacci
Autor:
John W. Upham, Julie G. Burel, Melanie L. Carroll, Antonia L. Pritchard, Simon Phipps, Olivia J. White
Publikováno v:
The Journal of Immunology. 188:5898-5905
Human rhinoviruses (RV) cause only minor illness in healthy individuals, but can have deleterious consequences in people with asthma. This study sought to examine normal homeostatic mechanisms regulating adaptive immunity to RV in healthy humans, foc
Autor:
Anthony Bosco, Patrick G. Holt, Olivia J. White, Katherine Mckenna, Peter Richmond, Anita H. J. van den Biggelaar
Publikováno v:
Vaccine. 30:1865-1874
Immune responses to vaccines in infants and young children are typically Th2-biased, giving rise to concerns regarding potential atopy-like side effects, and antagonism of Th1-associated sterilising immunity. Conventional immunological methodology ha
Autor:
Christophe von Garnier, Patrick G. Holt, Philip A. Stumbles, Olivia J. White, Peter D. Sly, Jennifer T. Burchell, Debra J. Turner, Alexander N. Larcombe, Matthew E. Wikstrom, Graeme R. Zosky
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 297:L373-L379
It is widely accepted that atopic asthma depends on an allergic response in the airway, yet the immune mechanisms that underlie the development of airway hyperresponsiveness (AHR) are poorly understood. Mouse models of asthma have been developed to s
Autor:
Alexander N. Larcombe, Patrick G. Holt, Debra J. Turner, Peter D. Sly, Jennifer T. Burchell, Zoltán Hantos, Olivia J. White, Graeme R. Zosky, Tibor Z. Jánosi
Publikováno v:
Clinical & Experimental Allergy. 38:829-838
Background: Asthma is a chronic inflammatory disease that is characterized clinically by airway hyperresponsiveness (AHR) to bronchoconstricting agents. The physiological response of the asthmatic lung to inhaled allergen is often characterized by tw
Autor:
Simon Phipps, Melanie L. Carroll, John W. Upham, Julie G. Burel, Antonia L. Pritchard, Olivia J. White
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 9, p e106501 (2014)
PLoS ONE, Vol 9, Iss 9, p e106501 (2014)
BackgroundHuman rhinovirus (HRV) infection is a major trigger for asthma exacerbations. Anti-viral immunity appears to be abnormal in asthma, with immune dysfunction reported in both airway structural cells and migratory, bone marrow derived cells. T
Autor:
John W. Upham, Julie G. Burel, Olivia J. White, David Looke, Antonia L. Pritchard, Janet M. Davies, Karthik Nath, Michelle Towers
Publikováno v:
Journal of Vaccines & Vaccination.
Background: Given that viral infections are common triggers for exacerbations of Chronic Obstructive Pulmonary Disease (COPD), current clinical guidelines recommend that all patients receive annual influenza vaccinations. A detailed examination of th
Publikováno v:
Immunology and cell biology. 90(10)
Several studies provided evidence of innate interferons (IFNs) regulating T(H)2 cytokine production using purified CD4(+) memory cells and T(H)2 polarisation via interleukin-4 (IL-4). Vitally, none of these previous studies examined IFN attenuation o