Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Olivia Ittoop"'
Autor:
Aaron B. Miller, Steve Blanchard, Kate A. Dwornik, Dallas K. Croom, Robert T. Gampe, Tom G. Consler, James M. Lenhard, Olivia Ittoop, Valerie G. Montana, Randy K. Bledsoe, and Andrea Ayscue, Darryl Lynn Mcdougald, Curt D. Haffner, H. Eric Xu
Publikováno v:
Journal of Medicinal Chemistry. 47:2010-2029
A series of tetrahydrobenzofuranyl and tetrahydrobenzothienyl propenoic acids that showed potent agonist activity against RXRalpha were synthesized via a structure-based design approach. Among the compounds studied, 46a,b showed not only very good po
Autor:
Izhar Ben-Shlomo, Olivia Ittoop, Cheryl Lohman, Eli Y. Adashi, Carol E. Resnick, Donna W. Payne, Eli Hazum, C Tedeschi
Publikováno v:
Biology of Reproduction. 51:1058-1065
Endothelins (ETs) are a family of vasoactive peptides that may be involved in granulosa cell (GC) luteinization or follicular maturation. However, the precise role of ET in ovarian physiology remains unknown. We have investigated whether the rat GC i
Publikováno v:
Endocrinology. 128:126-130
Competition binding experiments of [125I]endothelin-3 ([125I]ET-3) to bovine cerebellum membrane preparations in the presence of either ET-3 or ET-1 have indicated the presence of a single class of high affinity binding sites for these two peptides i
Publikováno v:
Endocrinology. 126:1829-1833
Specific binding sites for human/porcine endothelin have been found in rat brain membrane preparations using an [125I]endothelin. The apparent Kd value was 3 ± 2 nM with a Bmax value of 2,200 ± 200 fmol/mg protein. Chemical cross-linking of [125I]e
Autor:
William O. Wilkison, Timothy M. Willson, Olivia Ittoop, Hurley Kevin Patrick, Joan G. Wilson, Deborah A. Winegar, Peter Brown, L.William Stuart, Michael C. Lewis
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(9)
Using solid-phase, parallel-array synthesis, a series of urea-substituted thioisobutyric acids was synthesized and assayed for activity on the human PPAR subtypes. GW7647 (3) was identified as a potent human PPARalpha agonist with approximately 200-f
Autor:
Renu Jain, Furfine Eric Steven, James E. Weiel, Mark A. Paulik, Olivia Ittoop, James M. Lenhard, Lisa A. Orband-Miller, Steven G. Blanchard
Publikováno v:
Antiviral research. 47(2)
AIDS therapies employing HIV protease inhibitors (PIs) are associated with changes in fat metabolism. However, the cellular mechanisms affected by PIs are not clear. Thus, the affects of PIs on adipocyte differentiation were examined in vitro using C
Publikováno v:
Biochemistry. 30:5325-5327
Competition binding experiments and peptide mapping techniques were employed in order to directly address the possible existence of endothelin (ET) receptor subtypes in the atria. Competition binding assays for {sup 125}I-labeled Et-1 or {sup 125}I-l
Autor:
Steven G. Blanchard, James S. Nichols, Cole O. Harris, Olivia Ittoop, Derek J. Parks, Anne T. Truesdale, William O. Wilkison
Publikováno v:
Biochemistry. 34(33)
Several dominant mutations at the murine agouti locus result in the expression of a number of phenotypic changes, including a predominantly yellow coat color, obesity, and hyperinsulinemia. The mutants exhibit ectopic overexpression of normal agouti
Publikováno v:
Peptides. 13(1)
The mitogenic activity of endothelin (ET) was studied in osteoblast-like cells, MC3T3-E1. [3H] Thymidine incorporation induced by ET was markedly lower than that of platelet-derived growth factor (PDGF). ET synergistically stimulated [3H] thymidine i
Publikováno v:
Peptides. 12(6)
Biotinylated derivatives of endothelin (ET)-1 were prepared by chemical modification of ET-1 with sulfosuccinimidyl 6-(biotinamido) hexanoate. Two major biotinylated ET analogs were purified by reversed-phase high performance liquid chromatography. E