Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Olivia Grech"'
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/0a9a60b9766c4cc299f72abe95399c85
Autor:
James L Mitchell, Rebecca Buckham, Hannah Lyons, Jessica K Walker, Andreas Yiangou, Matilde Sassani, Mark Thaller, Olivia Grech, Zerin Alimajstorovic, Marianne Julher, Georgios Tsermoulas, Kristian Brock, Susan P Mollan, Alexandra J Sinclair
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Objectives Intracranial pressure (ICP) has been thought to vary diurnally. This study evaluates diurnal ICP measurements and quantifies changes in ICP occurring with changes in body posture in active idiopathic intracranial hypertension (IIH
Externí odkaz:
https://doaj.org/article/a265e97053aa4ab2852bb22ebdd0f478
Autor:
Olivia Grech, Matilde Sassani, Gisela Terwindt, Gareth G. Lavery, Susan P. Mollan, Alexandra J. Sinclair
Publikováno v:
The Journal of Headache and Pain, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background Migraine is a highly prevalent disorder with significant economical and personal burden. Despite the development of effective therapeutics, the causes which precipitate migraine attacks remain elusive. Clinical studies have highli
Externí odkaz:
https://doaj.org/article/1250d6f1d88b404195af0c35d2b334d4
Autor:
Andreas Yiangou, James L. Mitchell, Vivek Vijay, Olivia Grech, Edward Bilton, Gareth G. Lavery, Claire Fisher, Julie Edwards, Susan P. Mollan, Alexandra J. Sinclair
Publikováno v:
The Journal of Headache and Pain, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Headache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like characteristics. There are currently no evidence-based therapeutics for headache
Externí odkaz:
https://doaj.org/article/1ac7f5d16fb943f2a55bdf12b192d925
Autor:
Connar S.J. Westgate, Hannah F. Botfield, Zerin Alimajstorovic, Andreas Yiangou, Mark Walsh, Gabrielle Smith, Rishi Singhal, James L. Mitchell, Olivia Grech, Keira A. Markey, Daniel Hebenstreit, Daniel A. Tennant, Jeremy W. Tomlinson, Susan P. Mollan, Christian Ludwig, Ildem Akerman, Gareth G. Lavery, Alexandra J. Sinclair
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
BACKGROUND Idiopathic intracranial hypertension (IIH) is a condition predominantly affecting obese women of reproductive age. Recent evidence suggests that IIH is a disease of metabolic dysregulation, androgen excess, and an increased risk of cardiov
Externí odkaz:
https://doaj.org/article/ad869628076c4e20ba99df429a35f377
Publikováno v:
Life, Vol 11, Iss 6, p 472 (2021)
The pseudotumor cerebri syndrome embraces disorders characterised by raised intracranial pressure, where the commonest symptom is headache (90%). Idiopathic intracranial hypertension without papilloedema (IIHWOP) is increasingly recognised as a sourc
Externí odkaz:
https://doaj.org/article/cc709bb05e6e46efb84122ec37568407
Autor:
Olivia Grech, Susan P. Mollan, Benjamin R. Wakerley, Daniel Fulton, Gareth G. Lavery, Alexandra J. Sinclair
Publikováno v:
Life, Vol 11, Iss 5, p 415 (2021)
Migraine is a highly prevalent and disabling primary headache disorder, however its pathophysiology remains unclear, hindering successful treatment. A number of key secondary headache disorders have headaches that mimic migraine. Evidence has suggest
Externí odkaz:
https://doaj.org/article/5cd0bb0f4e5d430695cfd852a5364e3a
The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial
Autor:
James L Mitchell, Hannah S Lyons, Jessica K Walker, Andreas Yiangou, Olivia Grech, Zerin Alimajstorovic, Nigel H Greig, Yazhou Li, Georgios Tsermoulas, Kristian Brock, Susan P Mollan, Alexandra J Sinclair
Publikováno v:
Brain. 146:1821-1830
Therapeutics to reduce intracranial pressure are an unmet need. Preclinical data have demonstrated a novel strategy to lower intracranial pressure using glucagon-like peptide-1 (GLP-1) receptor signalling. Here, we translate these findings into patie
Autor:
Zerin Alimajstorovic, Susan P. Mollan, Olivia Grech, James L. Mitchell, Andreas Yiangou, Mark Thaller, Hannah Lyons, Matilde Sassani, Senali Seneviratne, Thomas Hancox, Andris Jankevics, Lukáš Najdekr, Warwick Dunn, Alexandra J. Sinclair
Publikováno v:
Journal of proteome research.
Autor:
Mark Thaller, Ryan S Ottridge, James L Mitchell, Gareth G. Lavery, Benjamin R Wakerley, Zerin Alimajstorovic, Alex J. Sinclair, Olivia Grech, Kristian Brock, Susan P Mollan, A Gupta, Andreas Yiangou
Publikováno v:
The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-9 (2021)
The Journal of Headache and Pain
The Journal of Headache and Pain
Objective Headache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate the association with intracranial pressure. Methods IIH:WT was a randomised controlled parallel group m