Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

Autor: Chiara Lanzillotta, Fabio Di Domenico, Marzia Perluigi, Massimo Castagnola, Federica Iavarone, D. Allan Butterfield, Eugenio Barone, Olivia Defever, Ilaria Zuliani, Antonella Tramutola, Cesira Foppoli, Federica Vincenzoni, Andrea Arena

Publikováno v: RedoxBiology 23 (2019): 1–14. doi:10.1016/j.redox.2019.101162
info:cnr-pdr/source/autori:Di Domenico F.; Tramutola A.; Barone E.; Lanzillotta C.; Defever O.; Arena A.; Zuliani I.; Foppoli C.; Iavarone F.; Vincenzoni F.; Castagnola M.; Butterfield D.A.; Perluigi M./titolo:Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome/doi:10.1016%2Fj.redox.2019.101162/rivista:RedoxBiology/anno:2019/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume:23
Redox Biology, Vol 23, Iss, Pp-(2019)
Redox Biology

Increasing evidences support the notion that the impairment of intracellular degradative machinery is responsible for the accumulation of oxidized/misfolded proteins that ultimately results in the deposition of protein aggregates. These events are ke

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http://www.cnr.it/prodotto/i/416594