Výsledky vyhledávání - "Olivia Debrah"

Synthesis of Poly(ethylene glycol)-Based Saquinavir Prodrug Conjugates and Assessment of Release and Anti-HIV-1 Bioactivity Using a Novel Protease Inhibition Assay

Autor: Olivia Debrah, Li Wan, Michael J. Leibowitz, Simi Gunaseelan, Arnold B. Rabson, Stanley Stein, Patrick J. Sinko

Publikováno v: Bioconjugate Chemistry. 15:1322-1333

Various poly(ethylene glycol)(PEG)-based prodrug conjugates of the HIV-1 protease inhibitor (PI) saquinavir (SQV) were prepared using several types of chemical groups potentially capable of modifying its pharmacokinetic properties. These prodrug conj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13248e05431720fbc6b2aaddb13cf760
https://doi.org/10.1021/bc0498875

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SYNTHESIS, CHARACTERIZATION, AND IN VITRO ASSAY OF FOLIC ACID CONJUGATES OF 3′-AZIDO-3′-DEOXYTHYMIDINE (AZT): TOWARD TARGETED AZT BASED ANTICANCER THERAPEUTICS

Autor: Anthony R. Vortherms, Olivia Debrah, Dayuan Gao, Robert P. Doyle, Patrick J. Sinko

Conjugates of three components namely folic acid, poly(ethyleneglycol) and 3 '-azido-3 '-deoxythymidine (AZT) are presented. Folate-PEG units were coupled to AZT to facilitate delivery of the nucleoside into the cell. A convenient separation of the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c396d43735474366a48516b821645c8
https://europepmc.org/articles/PMC2729114/

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Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects

Autor: Li Wan, Olivia Debrah, Stanley Stein, Shahriar Pooyan, Xiaoping Zhang, Patrick J. Sinko, Michael J. Leibowitz, Simi Gunaseelan, Arnold B. Rabson

Publikováno v: AIDS Research and Therapy, Vol 3, Iss 1, p 12 (2006)
AIDS Research and Therapy

Background Current anti-AIDS therapeutic agents and treatment regimens can provide a dramatically improved quality of life for HIV-positive people, many of whom have no detectable viral load for prolonged periods of time. Despite this, curing AIDS re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52c3530fc88e792fbb8ded2e4239743
https://doi.org/10.1186/1742-6405-3-12

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Novel multi-component nanopharmaceuticals for anti-HIV effects

Autor: Li Wan, Xiaoping Zhang, Simi Gunaseelan, Shahriar Pooyan, Olivia Debrah, Michael Leibowitz, Arnold Rabson, Stanley Stein, Patrick Sinko

Publikováno v: Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b00a99072d3bcedcb1c424e21f19f0
http://www.scopus.com/inward/record.url?eid=2-s2.0-85059494845&partnerID=MN8TOARS

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