Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy

Autor: Rachel Daley, Vishnu Maddipatla, Sayan Ghosh, Olivia Chowdhury, Stacey Hose, J. Samuel Zigler, Debasish Sinha, Haitao Liu

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)

Abstract Diabetic Retinopathy (DR) is a complication of diabetes that causes blindness in adults. Retinal fibrosis is closely associated with developing proliferative diabetic retinopathy (PDR). Clinical studies have shown that fibrotic membranes exh

Externí odkaz: https://doaj.org/article/b1455de008f94cd7aff9ed4e8a9cf405

Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy

Autor: Haitao Liu, Sayan Ghosh, Tanuja Vaidya, Sridhar Bammidi, Chao Huang, Peng Shang, Archana Padmanabhan Nair, Olivia Chowdhury, Nadezda A. Stepicheva, Anastasia Strizhakova, Stacey Hose, Nikolaos Mitrousis, Santosh Gopikrishna Gadde, Thirumalesh MB, Pamela Strassburger, Gabriella Widmer, Eleonora M. Lad, Patrice E. Fort, José-Alain Sahel, J. Samuel Zigler Jr., Swaminathan Sethu, Peter D. Westenskow, Alan D. Proia, Akrit Sodhi, Arkasubhra Ghosh, Derrick Feenstra, Debasish Sinha

Publikováno v: JCI Insight, Vol 8, Iss 12 (2023)

Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR

Externí odkaz: https://doaj.org/article/b18fbfa1ae7541e5a0a6f27bd00d5aed

Possible link between stress-related factors and altered body composition in women with polycystic ovarian syndrome

Autor: Barnali Ray Basu, Olivia Chowdhury, Sudip Kumar Saha

Publikováno v: Journal of Human Reproductive Sciences, Vol 11, Iss 1, Pp 10-18 (2018)

Background: Stress is an invisible factor affecting modern day living and is strongly associated with many disease pathogenesis including polycystic ovarian syndrome (PCOS) in women. PCOS is the most frequent endocrinological disorder that affects wo

Externí odkaz: https://doaj.org/article/3a138bd0bfa3441fb3e441c7140cebf8

Arsenic-induced differential inflammatory responses in mouse thymus involves NF-κB/STAT-3 disruption, Treg bias and autophagy activation

Autor: Ankur Das, Olivia Chowdhury, Payal Gupta, Nirmal Das, Ankan Mitra, Sourav Ghosh, Sayan Ghosh, Swaimanti Sarkar, Debasish Bandyopadhyay, Sreya Chattopadhyay

Publikováno v: Life Sciences. 314:121290

Arsenic contamination in drinking water is a world-wide public health concern. Sustained arsenic ingestion leads to immune alterations and subsequent development of inflammatory and autoimmune diseases; however, the underlying cellular and molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88e65e3bd3d711bbba26a865988bb97
https://doi.org/10.1016/j.lfs.2022.121290

A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for In Vitro Studies in AMD

Autor: Stacey Hose, Haitao Liu, Debasish Sinha, Donna B. Stolz, Ming Sun, Peng Shang, Nadezda A. Stepicheva, Olivia Chowdhury, Meysam Yazdankhah, Anastasia Strizhakova, Sayan Ghosh, Jonathan Franks, J. Samuel Zigler

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11979, p 11979 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21

Degeneration of retinal pigment epithelium (RPE) is one of the most critical phenotypic changes of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. While cultured polarized RPE cells with original properties ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9767aa77fc1999f0a69cbb6f97f13f16
https://www.mdpi.com/1422-0067/22/21/11979