Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Olivia C, Swann"'
Autor:
Ecco Staller, Loïc Carrique, Olivia C. Swann, Haitian Fan, Jeremy R. Keown, Carol M. Sheppard, Wendy S. Barclay, Jonathan M. Grimes, Ervin Fodor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Avian influenza A viruses (IAVs) pose a public health threat, as they are capable of triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian cells is hindered by species-specific variation in acidic nuclear
Externí odkaz:
https://doaj.org/article/00ffc1857d274ff1aec0d37f48d9400f
Autor:
Carol M. Sheppard, Daniel H. Goldhill, Olivia C. Swann, Ecco Staller, Rebecca Penn, Olivia K. Platt, Ksenia Sukhova, Laury Baillon, Rebecca Frise, Thomas P. Peacock, Ervin Fodor, Wendy S. Barclay
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Human ANP32A and ANP32B are essential but redundant host factors for influenza virus genome replication. While most influenza viruses cannot replicate in edited human cells lacking both ANP32A and ANP32B, some strains exhibit limited growth.
Externí odkaz:
https://doaj.org/article/9ea86ca4471f48e0947e131249f06d09
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Host restriction limits the emergence of novel pandemic strains from the influenza A virus avian reservoir. For efficient replication in mammalian cells, the avian influenza RNA-dependent RNA polymerase must adapt to use human orthologues of
Externí odkaz:
https://doaj.org/article/0c1bfdb66b284e93be5739ff29f446bc
Autor:
Brian Hanley, MBBCh, Kikkeri N Naresh, ProfMD, Candice Roufosse, PhD, Andrew G Nicholson, ProfDM, Justin Weir, FRCPath, Graham S Cooke, ProfFRCP, Mark Thursz, ProfMD, Pinelopi Manousou, PhD, Richard Corbett, PhD, Robert Goldin, ProfMD, Safa Al-Sarraj, ProfFRCPath, Alireza Abdolrasouli, PhD, Olivia C Swann, MRes, Laury Baillon, BSc, Rebecca Penn, MSc, Wendy S Barclay, ProfPhD, Patrizia Viola, MD, Michael Osborn, FRCPath
Publikováno v:
The Lancet Microbe, Vol 1, Iss 6, Pp e245-e253 (2020)
Summary: Background: Severe COVID-19 has a high mortality rate. Comprehensive pathological descriptions of COVID-19 are scarce and limited in scope. We aimed to describe the histopathological findings and viral tropism in patients who died of severe
Externí odkaz:
https://doaj.org/article/b910c056406e4a2cbe5e3619d204d092
Autor:
Sandra Gray‐Rodriguez, Melanie P Jensen, Maria Otero‐Jimenez, Brian Hanley, Olivia C Swann, Patrick A Ward, Francisco J Salguero, Nadira Querido, Ildiko Farkas, Elisavet Velentza‐Almpani, Justin Weir, Wendy S Barclay, Miles W Carroll, Zane Jaunmuktane, Sebastian Brandner, Ute Pohl, Kieren Allinson, Maria Thom, Claire Troakes, Safa Al‐Sarraj, Magdalena Sastre, Djordje Gveric, Steve Gentleman, Candice Roufosse, Michael Osborn, Javier Alegre‐Abarrategui
Publikováno v:
The Journal of Pathology. 257:198-217
Funder: Community Jameel Imperial College Covid‐19 Excellence Fund
Funder: NIHR Imperial College Healthcare NHS Trust Biomedical Research Centre
Funder: North West London Pathology Research Grant Commission
SARS-CoV-2, the causative
Funder: NIHR Imperial College Healthcare NHS Trust Biomedical Research Centre
Funder: North West London Pathology Research Grant Commission
SARS-CoV-2, the causative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830019334d8c37e18cf90075d9c7d99f
https://doi.org/10.1002/path.5878
https://doi.org/10.1002/path.5878
Host restriction limits the emergence of novel pandemic strains from the Influenza A Virus avian reservoir. For efficient replication in mammalian cells, the avian influenza RNA-dependent RNA polymerase must adapt to use human orthologues of the host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23e14e8145f1109d8e07cfb67b29c91
http://hdl.handle.net/10044/1/102627
http://hdl.handle.net/10044/1/102627
Autor:
Candice Roufosse, Michael Hollinshead, Wendy S. Barclay, Desley Neil, Catherine Horsfield, Olivia C. Swann, Brian Hanley, Linda B. Moran, Elizabeth Curtis
Publikováno v:
The Journal of Pathology
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in an urgent need to understand the pathophysiology of SARS-CoV-2 infection, to assist in the identification of treatment strategies. Viral tissue tropism is an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b1505c99836d454f846ccc9aaf5def
https://doi.org/10.1002/path.5547
https://doi.org/10.1002/path.5547
Autor:
Wendy S. Barclay, Mark Thursz, Rebecca Penn, Justin Weir, Patrizia Viola, Graham S Cooke, Andrew G. Nicholson, Candice Roufosse, Richard Corbett, Pinelopi Manousou, Robert D. Goldin, Laury Baillon, Safa Al-Sarraj, Olivia C. Swann, Alireza Abdolrasouli, Kikkeri N. Naresh, Michael Osborn, Brian Hanley
Publikováno v:
The Lancet Microbe
e253
e245
The Lancet. Microbe
The Lancet Microbe, Vol 1, Iss 6, Pp e245-e253 (2020)
e253
e245
The Lancet. Microbe
The Lancet Microbe, Vol 1, Iss 6, Pp e245-e253 (2020)
Summary: Background: Severe COVID-19 has a high mortality rate. Comprehensive pathological descriptions of COVID-19 are scarce and limited in scope. We aimed to describe the histopathological findings and viral tropism in patients who died of severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbda26adce5deac1afb2b77719e1cf14
https://doi.org/10.1016/s2666-5247(20)30115-4
https://doi.org/10.1016/s2666-5247(20)30115-4
Autor:
Laury Baillon, Rebecca Frise, Jack A. Hassard, Thomas P. Peacock, Mauro Giacca, Brian Hanley, Wendy S. Barclay, Jonathan Brown, Olivia C. Swann, Raul Y. Sanchez-David, David A. Matthews, Rebecca Penn, Luca Braga, Michael Osborn, Ruthiran Kugathasan, Ecco Staller, Andrew D. Davidson, Maia Kavanagh Williamson, Jie Zhou, Daniel H. Goldhill
Publikováno v:
Peacock, T P, Kavanagh Williamson, M, Davidson, A D, Matthews, D A, Barclay, W S & al., E 2021, ' The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets ', Nature Microbiology, vol. 6, no. 7, pp. 899-909 . https://doi.org/10.1038/s41564-021-00908-w
SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2' cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (PRRAR) at the S1/S2 cleavage site that can be cleaved by furin. Using le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e0ee5684faaff04732d4036d11db63
http://hdl.handle.net/10044/1/98544
http://hdl.handle.net/10044/1/98544
Autor:
Laury Baillon, Wendy S. Barclay, Blerina Ahmetaj-Shala, Jason Mitchell, Thomas P. Peacock, Hime Gashaw, Olivia C. Swann
RationaleThe secondary thrombotic/vascular clinical syndrome of COVID-19 suggests that SARS-CoV-2 infects not only respiratory epithelium but also the endothelium activating thrombotic pathways, disrupting barrier function and allowing access of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54b8516bee255a5ac028878406134809
https://doi.org/10.1101/2020.11.08.372581
https://doi.org/10.1101/2020.11.08.372581