Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Olivia Babb"'
Autor:
Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-24 (2021)
Abstract Background Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in th
Externí odkaz:
https://doaj.org/article/751a9e3c189b45859ea1d97745ceb7f8
Autor:
Olivia Babb, Fenil Shah, Lee Armstrong, Emily Hulsey, Hye-ran Moon, Amber L Mosely, Melissa L. Fishel, Jing-Ruey Joanna Yeh, Mark R. Kelley, Silpa Gampala, George E. Sandusky, Bumsoo Han, Nikkitha Umesh Ganesh, Chi Zhang, Mircea Ivan, Xiaoyu Lu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-24 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
BackgroundPancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in therapeutic
Autor:
Yan Tong, Silpa Gampala, Ellie Rad, Ren Yuan Bai, Olivia Babb, Emily Hulsey, Fenil Shah, Chi Zhang, Steven D. Rhodes, Verena Staedtke, Randall Wireman, Brian L. Calver, Mark R. Kelley, Michelle Grimard, M. Reza Saadatzadeh, Abbi Smith, D. Wade Clapp, Andrew R. Tee, Karen E. Pollok, Melissa L. Fishel
Publikováno v:
British Journal of Cancer
Background MPNST is a rare soft-tissue sarcoma that can arise from patients with NF1. Existing chemotherapeutic and targeted agents have been unsuccessful in MPNST treatment, and recent findings implicate STAT3 and HIF1-α in driving MPNST. The DNA-b
Autor:
Silpa Gampala, Fenil Shah, Chi Zhang, Steven D. Rhodes, Olivia Babb, Michelle Grimard, Randall S. Wireman, Ellie Rad, Brian Calver, Ren-Yuan Bai, Verena Staedtke, Emily L. Hulsey, M. Reza Saadatzadeh, Karen E. Pollok, Yan Tong, Abbi E. Smith, D. Wade Clapp, Andrew R. Tee, Mark R. Kelley, Melissa L. Fishel
Publikováno v:
British Journal of Cancer. 127:1378-1379
Biomimetic stiffening of cell-laden hydrogels via sequential thiol-ene and hydrazone click reactions
Publikováno v:
Acta Biomater
Hydrogels with dynamically tunable crosslinking are invaluable for directing stem cell fate and mimicking a stiffening matrix during fibrosis or tumor development. The increases in matrix stiffness during tissue development are often accompanied by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0530dedabc7a92c4d9df65afc689e2ee
https://europepmc.org/articles/PMC8316407/
https://europepmc.org/articles/PMC8316407/
Autor:
Nayela N. Chowdhury, Yi Yang, Yingnan Shen, Silpa Gampala, Olivia Babb, Bumsoo Han, Alisa S. Wolberg, Matthew J. Flick, Melissa L. Fishel
Publikováno v:
Cancer Research. 82:2447-2447
Pancreatic ductal adenocarcinoma (PDAC) exhibits one of the poorest prognoses of all solid cancers and is associated with very low overall and progression-free survival rate. Clinically, PDAC patient tumors show high expression levels of multiple com
Autor:
Mahmut Mijit, Olivia Babb, Silpa Gampala, Randall Wireman, Millie M. Georgiadis, Melissa L. Fishel, Mark R. Kelley
Publikováno v:
Cancer Research. 82:2366-2366
Ref-1/APE1 (Redox factor-1, Ref-1; Apurinic/apyrimidinic endonuclease 1, APE1) is a redox signaling enzyme that biochemically converts several transcription factors (TFs), such as NF-kB, STAT3, HIF-1α from an oxidized to a reduced state, allowing TF
Autor:
Silpa Gampala, Olivia Babb, Nikkitha Umesh Ganesh, Steven D. Rhodes, Reza M. Saadatzadeh, Kai Pollard, Christine Pratilas, Jing-Ruey Joanna Yeh, Karen E. Pollok, Wade D. Clapp, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Publikováno v:
Cancer Research. 82:2009-2009
Malignant Peripheral Nerve Sheath Tumor (MPNST) is a rare soft tissue sarcoma common in patients with NF1 (neurofibromatosis type 1). MPNSTs respond poorly to most chemotherapeutics due to molecular heterogeneity and altered signal transduction pathw
Autor:
Yan Tong, Michelle Grimard, Jack McGeown, Rachel A. Caston, Roberto Pili, Mark R. Kelley, Colton L. Starcher, Melissa L. Fishel, Fenil Shah, Karen E. Pollok, Teresa A. Zimmers, Joseph E. Rupert, Olivia Babb, Lee Armstrong, Adily N. Elmi, Edward A. Motea, Randall Wireman
Publikováno v:
Journal of Cellular and Molecular Medicine
With a plethora of molecularly targeted agents under investigation in cancer, a clear need exists to understand which pathways can be targeted simultaneously with multiple agents to elicit a maximal killing effect on the tumour. Combination therapy p
Autor:
Emily Hulsey, Olivia Babb, Silpa Gampala, Bumsoo Han, Rachel A. Caston, Randall Wireman, Hye-ran Moon, Andi R. Masters, James H. Wikel, Melissa L. Fishel, George E. Sandusky, Millie M. Georgiadis, Mark R. Kelley, Sara K. Quinney, Nayela N. Chowdhury
Publikováno v:
Cancer Research. 81:1452-1452
Targeted therapy for cancer using small molecules has progressed exponentially, but agents that can affect cancer cells rather than non-tumorigenic cells are crucial to avoid pernicious side effects. AP endonuclease-1/Redox factor-1 (APE1/Ref-1 or Re