Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Olivia, Mekhael"'
Autor:
Steven P. Cass, Olivia Mekhael, Danya Thayaparan, Joshua J. C. McGrath, Spencer D. Revill, Matthew F. Fantauzzi, Peiyao Wang, Amir Reihani, Aaron I. Hayat, Christopher S. Stevenson, Anna Dvorkin-Gheva, Fernando M. Botelho, Martin R. Stämpfli, Kjetil Ask
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
RationaleThe accumulation of macrophages in the airways and the pulmonary interstitium is a hallmark of cigarette smoke-associated inflammation. Notably, pulmonary macrophages are not a homogenous population but consist of several subpopulations. To
Externí odkaz:
https://doaj.org/article/42863354dc984044af4890b5d31645bc
Autor:
Olivia Mekhael, Spencer D Revill, Aaron I Hayat, Steven P Cass, Kyle MacDonald, Megan Vierhout, Anmar Ayoub, Amir Reihani, Manreet Padwal, Jewel Imani, Ehab Ayaub, Tamana Yousof, Anna Dvorkin‐Gheva, Anthony Rullo, Jeremy A Hirota, Carl D Richards, Darren Bridgewater, Martin R Stämpfli, Nathan Hambly, Asghar Naqvi, Martin RJ Kolb, Kjetil Ask
Publikováno v:
Immunology & Cell Biology. 101:412-427
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86811152d9f53086c27b48bf2172b314
https://doi.org/10.1111/imcb.12637
https://doi.org/10.1111/imcb.12637
Autor:
Spencer Revill, Pierre-Simon Bellaye, Martin Kolb, Karun Tandon, Kjetil Ask, Nathan Hambly, Ehab A. Ayaub, Jean-Claude Cutz, Philipp Kolb, Asghar Naqvi, Tamana Yousof, Martha M. Vaughan, Jiro Kato, Safaa Naiel, Megan Vierhout, Soumeya Abed, Anmar Ayoub, Joel Moss, Manreet Padwal, Anna Dvorkin-Gheva, Victor Tat, Olivia Mekhael
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:235-246
Pulmonary fibrosis is a progressive lung disease characterized by myofibroblast accumulation and excessive extracellular matrix deposition. Endoplasmic reticulum (ER) stress initiates the unfolded protein response (UPR), a cellular stress response pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813e63ee9e89068286356ebacfc0eb8a
https://doi.org/10.1165/rcmb.2020-0121oc
https://doi.org/10.1165/rcmb.2020-0121oc
Autor:
Olivia Mekhael, Manreet Padwal, Anna Dvorkin-Gheva, Anmar Ayoub, Tamana Yousof, Soumeya Abed, Safaa Naiel, Victor Tat, Megan Vierhout, Kjetil Ask
Publikováno v:
Chest. 157:1207-1220
Chronic lung disease accounts for a significant global burden with respect to death, disability, and health-care costs. Due to the heterogeneous nature and limited treatment options for these diseases, it is imperative that the cellular and molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81945c6cf8e20813e4ea37e776d3d1bc
https://doi.org/10.1016/j.chest.2019.11.009
https://doi.org/10.1016/j.chest.2019.11.009
Autor:
Olivia, Mekhael, Safaa, Naiel, Megan, Vierhout, Aaron I, Hayat, Spencer D, Revill, Soumeya, Abed, Mark D, Inman, Martin R J, Kolb, Kjetil, Ask
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2299
The drug discovery pipeline, from discovery of therapeutic targets through preclinical and clinical development phases, to an approved product by health authorities, is a time-consuming and costly process, where a lead candidates' success at reaching
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb9548e6fc6906a4c91a39a21a19091b
https://pubmed.ncbi.nlm.nih.gov/34028751
https://pubmed.ncbi.nlm.nih.gov/34028751
Autor:
Olivia Mekhael, Aaron Hayat, Martin Kolb, Spencer Revill, Soumeya Abed, Kjetil Ask, Safaa Naiel, Megan Vierhout, Mark D. Inman
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613818
The drug discovery pipeline, from discovery of therapeutic targets through preclinical and clinical development phases, to an approved product by health authorities, is a time-consuming and costly process, where a lead candidates' success at reaching
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e813604e5b1fdd8968e4532c3ee33f7
https://doi.org/10.1007/978-1-0716-1382-5_21
https://doi.org/10.1007/978-1-0716-1382-5_21
Autor:
Spencer Revill, Manreet Padwal, Kjetil Ask, Asghar Naqvi, Anmar Ayoub, E. Chu, Nathan Hambly, Olivia Mekhael, Aaron Hayat, Jean-Claude Cutz, Martin Kolb, Jeremy A. Hirota, Anna Dvorkin-Gheva, Megan Vierhout
Publikováno v:
A62. LUNG FIBROSIS: INSIGHTS FROM THE BENCH.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb552891e1337b98bd866a352342e29
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2237
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2237
Autor:
Spencer Revill, Mark W. Surber, Gali Epstein-Shochet, A. Bruce Montgomery, Kjetil Ask, Safaa Naiel, Martin Kolb, Olivia Mekhael, Aaron Hayat, David Shitrit, Becky Bardestein-Wald, Steven Beck, Stephen Pham, Megan Vierhout
Oral nintedanib is marketed for the treatment of idiopathic pulmonary fibrosis (IPF). While effective slowing fibrosis progression, as an oral medicine nintedanib is limited. To reduce side effects and maximize efficacy, nintedanib was reformulated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0362851a07f4d08472f71fed691d55b
Autor:
Anmar Ayoub, Šárka Lhoták, Ehab A. Ayaub, Anna Dvorkin-Gheva, Manreet Padwal, Chandak Upagupta, Philipp Kolb, Kjetil Ask, James Murphy, Martin Kolb, Richard C. Austin, Carl D. Richards, Hemisha Patel, Jewel Imani, Anisha Dubey, Karun Tandon, Olivia Mekhael, Jeffrey G. Dickhout
Publikováno v:
Immunology and Cell Biology
Although recent evidence has shown that IL‐6 is involved in enhanced alternative activation of macrophages toward a profibrotic phenotype, the mechanisms leading to their increased secretory capacity are not fully understood. Here, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518faae0856261ea16bc3224d32f44c2
http://europepmc.org/articles/PMC7379543
http://europepmc.org/articles/PMC7379543
Autor:
Aaron Hayat, Victor Tat, Safaa Naiel, Nickolas Serniuck, Kjetil Ask, Megan Vierhout, Olivia Mekhael, Anthony F. Rullo, Rebecca C. Turner, Soumeya Abed
Publikováno v:
Biochemical Pharmacology. 190:114577
Non-targeted drug delivery systems have several limitations including the decreased bioavailability of the drug, poor stability and rapid clearance in addition to off-target distribution. Cell-specific targeted delivery approaches promise to overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9404dc72e8847ff4fa2078d8112772a
https://doi.org/10.1016/j.bcp.2021.114577
https://doi.org/10.1016/j.bcp.2021.114577