Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Olivera, Grubisha"'
Autor:
Chloe R. Koulouris, Sian E. Gardiner, Tessa K. Harris, Karen T. Elvers, S. Mark Roe, Jason A. Gillespie, Simon E. Ward, Olivera Grubisha, Robert A. Nicholls, John R. Atack, Benjamin D. Bax
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The catalytic mechanisms of human serine racemase reveal a ligandable pocket near Tyr121 that could be targeted for the development of novel inhibitors.
Externí odkaz:
https://doaj.org/article/08d2829bfb8f4f288b7fb5de272a4d80
Autor:
Ross Collins, Hyunah Lee, D. Heulyn Jones, Jonathan M. Elkins, Jason A. Gillespie, Carys Thomas, Alex G. Baldwin, Kimberley Jones, Loren Waters, Marie Paine, John R. Atack, Simon E. Ward, Olivera Grubisha, David W. Foley
Publikováno v:
Journal of Medicinal Chemistry. 65:13705-13713
LIM domain kinases 1 and 2 (LIMK1 and LIMK2) regulate actin dynamics and subsequently key cellular functions such as proliferation and migration. LIMK1 and LIMK2 phosphorylate and inactivate cofilin leading to increased actin polymerization. As a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec61e46daab0767af551fe05809ccb38
https://doi.org/10.1021/acs.jmedchem.2c00751
https://doi.org/10.1021/acs.jmedchem.2c00751
Autor:
Haiyan An, Karen T Elvers, Jason A Gillespie, Kimberley Jones, John R Atack, Olivera Grubisha, Tatyana A Shelkovnikova
Publikováno v:
Nucleic acids research. 50(20)
Paraspeckles are ribonucleoprotein granules assembled by NEAT1_2 lncRNA, an isoform of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1). Dysregulation of NEAT1_2/paraspeckles has been linked to multiple human diseases making them an attractive drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2225c4e70b8d612b18d10a1d1c7d9e7
https://pubmed.ncbi.nlm.nih.gov/36099417
https://pubmed.ncbi.nlm.nih.gov/36099417
Autor:
Chloe R, Koulouris, Sian E, Gardiner, Tessa K, Harris, Karen T, Elvers, S, Mark Roe, Jason A, Gillespie, Simon E, Ward, Olivera, Grubisha, Robert A, Nicholls, John R, Atack, Benjamin D, Bax
Publikováno v:
Communications biology. 5(1)
Human serine racemase (hSR) catalyses racemisation of L-serine to D-serine, the latter of which is a co-agonist of the NMDA subtype of glutamate receptors that are important in synaptic plasticity, learning and memory. In a 'closed' hSR structure con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82c5a0696958e8707974e024cedc3442
https://pubmed.ncbi.nlm.nih.gov/35410329
https://pubmed.ncbi.nlm.nih.gov/35410329
Autor:
Charles V. Vorhees, Michael T. Williams, Jillian R. Hufgard, Filipa M. Ferreira, Tracy M. Reed-Kessler, Mary E. Wright, Matthew R. Skelton, Ronald S. Duman, Olivera Grubisha, Kurt Rasmussen, Helen E. Sanger
Publikováno v:
Psychopharmacology. 234:1803-1813
Rationale Major depressive disorder is a leading cause of suicide and disability. Despite this, current antidepressants provide insufficient efficacy in more than 60% of patients. Most current antidepressants are presynaptic reuptake inhibitors; post
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6f937327161db63f3d829e204b4ff9
https://doi.org/10.1007/s00213-017-4587-8
https://doi.org/10.1007/s00213-017-4587-8
Autor:
Olivera Grubisha, Suchira Bose, Camille Soubrane, Mike Hutton, Michael J. O'Neill, Antigoni Katsikoudi, Antoine Fouillet, Daniel Ursu, Lisa M. Broad, Annalisa Cavallini
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa542cc054f5a48075d97a7a4e7467c
https://doi.org/10.1016/j.jalz.2017.06.1291
https://doi.org/10.1016/j.jalz.2017.06.1291
Autor:
Helen E. Sanger, Adrian J. Mogg, Laura-Jayne Ball, Lisa M. Broad, Daniel Ursu, Olivera Grubisha, Cara L. Ruble, Elizabeth A. Folly, Jessica L Sorge
Publikováno v:
British Journal of Pharmacology. 171:2631-2644
Background and Purpose Transient receptor potential vanilloid subtype 3 (TRPV3) is implicated in nociception and certain skin conditions. As such, it is an attractive target for pharmaceutical research. Understanding of endogenous TRPV3 function and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b576320d39213f8f3a961b22cbdba2
https://doi.org/10.1111/bph.12303
https://doi.org/10.1111/bph.12303
Autor:
Ellen M. Colvin, Emanuele Sher, Olivera Grubisha, Richard G. Vivier, James A. Monn, Lydia Hanna, Jeremy Findlay, Beverly A. Heinz, Lisa M. Broad, David Lodge, Daniel Ursu, Helen E. Sanger
Publikováno v:
Neuropharmacology. 66:264-273
The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential targets for psychiatric disorders, including anxiety and schizophrenia. In addition to studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec5be3a3cdca1fba4e9c5e68a225f7b
https://doi.org/10.1016/j.neuropharm.2012.05.023
https://doi.org/10.1016/j.neuropharm.2012.05.023
Publikováno v:
FEBS Journal. 272:4607-4616
The Sir2 family of histone/protein deacetylases (sirtuins) is comprised of homologues found across all kingdoms of life. These enzymes catalyse a unique reaction in which NAD+ and acetylated substrate are converted into deacetylated product, nicotina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41843282813607345cf4900e28354bdb
https://doi.org/10.1111/j.1742-4658.2005.04862.x
https://doi.org/10.1111/j.1742-4658.2005.04862.x
Autor:
Paula Traktman, Olivera Grubisha
Publikováno v:
Journal of Virology. 77:10929-10942
The linear, double-stranded DNA genome of vaccinia virus contains covalently closed hairpin termini. These hairpin termini comprise a terminal loop and an A+T-rich duplex stem that has 12 extrahelical bases. DeMasi et al. have shown previously that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e8822a2f6d68e6427082428a614c4b
https://doi.org/10.1128/jvi.77.20.10929-10942.2003
https://doi.org/10.1128/jvi.77.20.10929-10942.2003