Characteristics of RSV-Specific Maternal Antibodies in Plasma of Hospitalized, Acute RSV Patients under Three Months of Age.

Autor: Jop Jans, Oliver Wicht, Ivy Widjaja, Inge M L Ahout, Ronald de Groot, Teun Guichelaar, Willem Luytjes, Marien I de Jonge, Cornelis A M de Haan, Gerben Ferwerda

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170877 (2017)

Respiratory syncytial virus (RSV) is the leading cause for respiratory illness that requires hospitalization in infancy. High levels of maternal antibodies can protect against RSV infection. However, RSV-infected infants can suffer from severe diseas

Externí odkaz: https://doaj.org/article/f036abda9e974609bc195e2fe49fbfb7

Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase.

Autor: Christine Burkard, Louis-Marie Bloyet, Oliver Wicht, Frank J van Kuppeveld, Peter J M Rottier, Cornelis A M de Haan, Berend Jan Bosch

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e101762 (2014)

Studies of viral entry into host cells often rely on the detection of post-entry parameters, such as viral replication or the expression of a reporter gene, rather than on measuring entry per se. The lack of assays to easily detect the different step

Externí odkaz: https://doaj.org/article/39de291686d94fdaabb6cf7a2379338a

Respiratory Syncytial Virus Infects Primary Neonatal and Adult Natural Killer Cells and Affects Their Antiviral Effector Function

Autor: Gerben Ferwerda, Oliver Wicht, Willem Luytjes, Elisabeth A. van Erp, Dorien Feyaerts, Puck B. van Kasteren, Maxime Duijst, H. Lie Mulder

Publikováno v: The Journal of Infectious Diseases, 219, 5, pp. 723-733
The Journal of Infectious Diseases
The Journal of Infectious Diseases, 219, 723-733

Background Respiratory syncytial virus (RSV) is a major cause of severe acute lower respiratory tract infections in infants. Natural killer (NK) cells are important antiviral effector cells that likely encounter RSV in the presence of virus-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa8f8a68c49304ae2772729d5751778
https://doi.org/10.1093/infdis/jiy566

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

Autor: Volker Lohmann, Joseph Marcotrigiano, Andreas Pichlmair, Laurène Meyniel-Schicklin, Sandra Bastian, Holger Erfle, Nina Baur, Oliver Wicht, Petr Matula, Karl Rohr, Darya A. Haas, Julia C. Wolanski, Chen Wang, Joschka Willemsen, Marco Binder, Lars Kaderali, Bettina Knapp, Ralf Bartenschlager

Publikováno v: Molecular Cell

Cell-autonomous induction of type I interferon must be stringently regulated. Rapid induction is key to control virus infection, whereas proper limitation of signaling is essential to prevent immunopathology and autoimmune disease. Using unbiased kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640786e35c03c8abeab6f50a9d87a3c8
https://doi.org/10.1016/j.molcel.2016.12.021

A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across Genotypes

Autor: Rahel Klein, Philip C. Simister, Peter Friebe, Melanie Schmitt, Célia Caillet-Saguy, Nathalie Scrima, Oliver Wicht, Volker Lohmann, Danijela Radujkovic, Stéphane Bressanelli, Ralf Bartenschlager

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2011, 85 (6), pp.2565-2581. ⟨10.1128/JVI.02177-10⟩

The hepatitis C virus (HCV) genotype 2a isolate JFH1 represents the only cloned HCV wild-type sequence capable of efficient replication in cell culture as well as in vivo . Previous reports have pointed to NS5B, the viral RNA-dependent RNA polymerase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419c3638838ad4f6437b62ff76e1837b
https://hal.archives-ouvertes.fr/hal-03229799