Zobrazeno 1 - 10
of 521
pro vyhledávání: '"Oliver Werz"'
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
Autor:
Samim Sharifi, Prerana Chaudhari, Asya Martirosyan, Alexander Otto Eberhardt, Finja Witt, André Gollowitzer, Lisa Lange, Yvonne Woitzat, Eberechukwu Maryann Okoli, Huahui Li, Norman Rahnis, Joanna Kirkpatrick, Oliver Werz, Alessandro Ori, Andreas Koeberle, Holger Bierhoff, Maria Ermolaeva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the underlying mechanisms were not studied beyond effects on nucleolar st
Externí odkaz:
https://doaj.org/article/e8c06c7d253c4ce7a8ddf6f0c29bac62
Autor:
Jelle Y. Broos, Rianne T. M. van der Burgt, Julia Konings, Merel Rijnsburger, Oliver Werz, Helga E. de Vries, Martin Giera, Gijs Kooij
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration. Considering the increasing prevalence among young adults worldw
Externí odkaz:
https://doaj.org/article/b8147a83a1be4f0c90161f152952badb
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Introduction: Frankincense preparations are frequently used as traditional anti-inflammatory remedies in folk medicine with increasing popularity. Boswellic acids (BAs), especially 3-O-acetyl-11-keto-βBA (AKBA), are unique anti-inflammatory principl
Externí odkaz:
https://doaj.org/article/059919f6f9f74bef965e638b2a7b0738
Autor:
Paul M. Jordan, Kerstin Günther, Vivien Nischang, Yuping Ning, Stefanie Deinhardt-Emmer, Christina Ehrhardt, Oliver Werz
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108775- (2024)
Summary: Respiratory influenza A virus (IAV) infections are major health concerns worldwide, where bacterial superinfections substantially increase morbidity and mortality. The underlying mechanisms of how IAV impairs host defense remain elusive. Mac
Externí odkaz:
https://doaj.org/article/0df6c0415d83414ea7b08d7b6d214951
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/2698cbdf676c442598a0a8d2d079aef2
Autor:
Mira Behnke, Paul Klemm, Philipp Dahlke, Blerina Shkodra, Baerbel Beringer-Siemers, Justyna Anna Czaplewska, Steffi Stumpf, Paul M. Jordan, Stephanie Schubert, Stephanie Hoeppener, Antje Vollrath, Oliver Werz, Ulrich S. Schubert
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100173- (2023)
Dextran-based polymers, such as ethoxy acetalated dextran (Ace-DEX), are increasingly becoming the focus of research as they offer great potential for the development of polymer-based nanoparticles as drug delivery vehicles. Their major advantages ar
Externí odkaz:
https://doaj.org/article/b5255fcdcde943ff8dde7959ac12a97d
Autor:
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/b3d159e06f4847f1b24760698cd429a2
Autor:
Abdurrahman Olğaç, İrfan Çapan, Philipp Dahlke, Paul M. Jordan, Oliver Werz, Erden Banoglu
Publikováno v:
ACS Omega, Vol 8, Iss 34, Pp 31293-31304 (2023)
Externí odkaz:
https://doaj.org/article/b0c6207c4cc246c0b91b84b8da0a22c3
Autor:
Bodo Speckmann, Tanja Wagner, Paul M. Jordan, Oliver Werz, Manfred Wilhelm, Heike tom Dieck, Christiane Schön
Publikováno v:
Nutrients, Vol 16, Iss 9, p 1354 (2024)
Beneficial health effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) are partly attributed to specialized pro-resolving mediators (SPMs), which promote inflammation resolution. Strategies to improve n-3 PUFA conversion to SPMs may, therefore,
Externí odkaz:
https://doaj.org/article/11026afa985846ea9209c5bbc08cc994
Autor:
Paul Zahel, Vera Bruggink, Juliana Hülsmann, Frank Steiniger, Robert K. Hofstetter, Thorsten Heinzel, Uwe Beekmann, Oliver Werz, Dana Kralisch
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 504 (2024)
The effective pharmacological treatment of inflamed wounds such as pyoderma gangraenosum remains challenging, as the systemic application of suitable drugs such as glucocorticoids is compromised by severe side effects and the inherent difficulties of
Externí odkaz:
https://doaj.org/article/125c768a7dd742e4b5bdcb2b6b88463e