Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Oliver Teenan"'
Autor:
Katie L. Connor, Oliver Teenan, Carolynn Cairns, Victoria Banwell, Rachel A.B. Thomas, Julie Rodor, Sarah Finnie, Riinu Pius, Gillian M. Tannahill, Vishal Sahni, Caroline O.S. Savage, Jeremy Hughes, Ewen M. Harrison, Robert B. Henderson, Lorna P. Marson, Bryan R. Conway, Stephen J. Wigmore, Laura Denby
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Small noncoding RNAs, miRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney disease onset, progression, or therapeutic efficacy. Bulk tissue small RNA-sequencing (sRNA-Seq)
Externí odkaz:
https://doaj.org/article/0e57397672654b13af1fc22e1d4a45d8
Autor:
James O’Sullivan, Sarah Louise Finnie, Oliver Teenan, Carolynn Cairns, Andrew Boyd, Matthew A. Bailey, Adrian Thomson, Jeremy Hughes, Cécile Bénézech, Bryan Ronald Conway, Laura Denby
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Chronic kidney disease (CKD) is prevalent worldwide and is associated with significant co-morbidities including cardiovascular disease (CVD). Traditionally, the subtotal nephrectomy (remnant kidney) experimental model has been performed in rats to mo
Externí odkaz:
https://doaj.org/article/4030948669044e64aad1e6228a22ae92
Autor:
Oliver Teenan, Vishal Sahni, Robert B. Henderson, Bryan R. Conway, Carmel M. Moran, Jeremy Hughes, Laura Denby
Publikováno v:
Teenan, O, Sahni, V, Henderson, R B, Conway, B R, Moran, C M, Hughes, J & Denby, L 2022, ' Sonoporation of human renal proximal tubular epithelial cells in vitro to enhance the liberation of intracellular miRNA biomarkers. ', Ultrasound in Medicine and Biology (UMB) . https://doi.org/10.1016/j.ultrasmedbio.2022.01.019
Ultrasound has previously been demonstrated to non-invasively cause tissue disruption. Small animal studies have demonstrated that this effect can be enhanced by contrast microbubbles and has the potential to be clinically beneficial in techniques su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3002672e1be35f6f764e3f74ebf3d9
https://www.pure.ed.ac.uk/ws/files/251511161/Teenan_et_al_2020_v13_revised_January_2022.docx
https://www.pure.ed.ac.uk/ws/files/251511161/Teenan_et_al_2020_v13_revised_January_2022.docx
Autor:
Laura Denby, R Thomas, Victoria Banwell, Stephen J. Wigmore, Bryan R. Conway, Katie Connor, Sarah Finnie, Ewen M Harrison, ML Monaghan, Lorna Marson, Oliver Teenan, Gillian M Tannahill, Carolynn Cairns
Publikováno v:
British Journal of Surgery. 108
Introduction MicroRNAs are promising biomarkers of renal disease, however the cellular origin of their expression is usually unclear limiting their interpretation when measured in renal biopsies and urine. We hypothesised that by first defining renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a15f32d2833b16e2a4dfac92bad8663
https://doi.org/10.1093/bjs/znab117.045
https://doi.org/10.1093/bjs/znab117.045
Autor:
Cécile Bénézech, Carolynn Cairns, Oliver Teenan, Katie Connor, James O’sullivan, Angela Salzano, David A. Ferenbach, Kevin Stewart, Eoin O'Sullivan, Neil C. Henderson, Peng Ding, Riinu Pius, Jeremy Hughes, Tamir Chandra, Laura Denby, Duncan Humphries, Prakash Ramachandran, Bryan R. Conway, Daniel J. Simpson
Publikováno v:
J Am Soc Nephrol
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806
Conway, B R, O Sullivan, E, Cairns, C, O'Sullivan, J, Simpson, D, Salzano, A, Connor, K, Ding, P, Humphries, D, Stewart, K, Teenan, O, Pius, R, Henderson, N C, Benezech, C, Ramachandran, P, Ferenbach, D A, Hughes, J, Chandra, T & Denby, L 2020, ' Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease ', Journal of the American Society of Nephrology, vol. 31, no. 12, pp. 2833–2854 . https://doi.org/10.1681/ASN.2020060806
Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c985622a807b7b39dbcfe20eb66ca7
https://pubmed.ncbi.nlm.nih.gov/32978267
https://pubmed.ncbi.nlm.nih.gov/32978267
Autor:
Julie Rodor, Stephen J. Wigmore, Oliver Teenan, Caroline O. S. Savage, Riinu Pius, Carolynn Cairns, Jeremy Hughes, Bryan R. Conway, Robert B Henderson, Sarah Finnie, Katie Connor, Vishal Sahni, Lorna P. Marson, Gillian M Tannahill, Laura Denby, Ewen M Harrison, Victoria Banwell, Rachel Thomas
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
Connor, K L, Teenan, O, Cairns, C, Banwell, V, Thomas, R A B, Rodor, J, Finnie, S, Pius, R, Tannahill, G M, Sahni, V, Savage, C O S, Hughes, J, Harrison, E M, Henderson, R B, Marson, L P, Conway, B R, Wigmore, S J & Denby, L 2020, ' Identifying cell enriched miRNAs in kidney injury and repair ', JCI Insight, vol. 5, no. 24, e140399 . https://doi.org/10.1172/jci.insight.140399
JCI Insight, Vol 5, Iss 24 (2020)
Connor, K L, Teenan, O, Cairns, C, Banwell, V, Thomas, R A B, Rodor, J, Finnie, S, Pius, R, Tannahill, G M, Sahni, V, Savage, C O S, Hughes, J, Harrison, E M, Henderson, R B, Marson, L P, Conway, B R, Wigmore, S J & Denby, L 2020, ' Identifying cell enriched miRNAs in kidney injury and repair ', JCI Insight, vol. 5, no. 24, e140399 . https://doi.org/10.1172/jci.insight.140399
Small noncoding RNA, microRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney disease onset, progression or possibly outcome from treatment. Bulk tissue small RNA-Sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23dce84afec171299aec21c13b969bf
https://pubmed.ncbi.nlm.nih.gov/33328386
https://pubmed.ncbi.nlm.nih.gov/33328386
Autor:
Angela Salzano, Katie Connor, Oliver Teenan, Carolynn Cairns, Peng Ding, Jeremy Hughes, Tamir Chandra, Duncan Humphries, David A. Ferenbach, James O’sullivan, Eoin O'Sullivan, Cécile Bénézech, Kevin Stewart, Bryan R. Conway, Neil C. Henderson, Prakash Ramachandran, Laura Denby, Daniel J. Simpson
The kidney has a limited capacity to repair following injury, however, the endogenous reparative pathways are not well understood. Here we employ integrated droplet- and plate-based scRNA-seq in the murine reversible unilateral ureteric obstruction m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3634dd208de10fa924991efa0e0544d4
https://doi.org/10.1101/2020.05.14.095166
https://doi.org/10.1101/2020.05.14.095166
Autor:
Laura Denby, Cécile Bénézech, Andrew Boyd, Adrian Thomson, Bryan R. Conway, Carolynn Cairns, James O’sullivan, Matthew A. Bailey, Sarah Finnie, Oliver Teenan, Jeremy Hughes
Publikováno v:
O’sullivan, J, Finnie, S L, Teenan, O, Cairns, C, Boyd, A, Bailey, M A, Thomson, A, Hughes, J, Bénézech, C, Conway, B R & Denby, L 2019, ' Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction ', Frontiers in physiology, vol. 10, 1365 . https://doi.org/10.3389/fphys.2019.01365
O’sullivan, J, Finnie, S L, Teenan, O, Cairns, C, Boyd, A, Bailey, M A, Thomson, A, Hughes, J, Bénézech, C, Conway, B R & Denby, L 2019, ' Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction ', Frontiers in physiology, vol. 10, 1365 . https://doi.org/10.3389/fphys.2019.01365, https://doi.org/10.3389/fphys.2019.01365
Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology
O’sullivan, J, Finnie, S L, Teenan, O, Cairns, C, Boyd, A, Bailey, M A, Thomson, A, Hughes, J, Bénézech, C, Conway, B R & Denby, L 2019, ' Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction ', Frontiers in physiology, vol. 10, 1365 . https://doi.org/10.3389/fphys.2019.01365, https://doi.org/10.3389/fphys.2019.01365
Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology
Chronic kidney disease (CKD) is prevalent worldwide and is associated with significant co-morbidities including cardiovascular disease. Traditionally, the subtotal nephrectomy (remnant kidney) experimental model has been performed in rats to model pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b06970ee666a6e76370be1a3aa922f5
https://hdl.handle.net/20.500.11820/f3e2a951-cc01-4f52-875b-54d4cfd70656
https://hdl.handle.net/20.500.11820/f3e2a951-cc01-4f52-875b-54d4cfd70656