Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Oliver T. Parkinson"'
Autor:
Eva M Schmidt, Constanze Wiek, Oliver T Parkinson, Katharina Roellecke, Marcel Freund, Michael Gombert, Nadine Lottmann, Charles A Steward, Christof M Kramm, Vladimir Yarov-Yarovoy, Allan E Rettie, Helmut Hanenberg
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137110 (2015)
CYP4B1 belongs to the cytochrome P450 family 4, one of the oldest P450 families whose members have been highly conserved throughout evolution. The CYP4 monooxygenases typically oxidize fatty acids to both inactive and active lipid mediators, although
Externí odkaz:
https://doaj.org/article/261fb5b8bb424db787a397f4d477e106
Publikováno v:
Drug Metabolism and Disposition. 44:1598-1602
4-Ipomeanol (IPO) is a model pulmonary toxicant that undergoes P450-mediated metabolism to reactive electrophilic intermediates that bind to tissue macromolecules and can be trapped in vitro as the NAC/NAL adduct. Pronounced species and tissue differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbe201e07f504e17c39896093b27797
https://doi.org/10.1124/dmd.116.070003
https://doi.org/10.1124/dmd.116.070003
Autor:
John P. Kowalski, Constanze Wiek, Dale Whittington, Aaron M. Teitelbaum, Allan E. Rettie, Oliver T. Parkinson, Helmut Hanenberg, Michele Scian, Matthew G. McDonald, Katharina Roellecke
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 368(2)
A potential CYP4B1 suicide gene application in engineered T-cell treatment of blood cancers has revived interest in the use of 4-ipomeanol (IPO) in gene-directed enzyme prodrug therapy, in which disposition of the administered compound may be critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff0d793eb1d71a8a314d33506d92b82
https://pubmed.ncbi.nlm.nih.gov/30409834
https://pubmed.ncbi.nlm.nih.gov/30409834
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 35:402-405
4-Ipomeanol (IPO1; 1-(3-Furyl)-4-hydroxy-1-pentanone) is a furanoterpenoid toxin produced by sweet potatoes (Ipomoea batatas) in response to infection by the mold Fusariam solani (Doster et al., 1978). Cattle that ingest infected sweet potatoes can d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dda5c67567ef1c8335021efe82ffe40
https://doi.org/10.1111/j.1365-2885.2011.01339.x
https://doi.org/10.1111/j.1365-2885.2011.01339.x
Autor:
Katharina Roellecke, Michael Gombert, Christof M. Kramm, Constanze Wiek, Charles A. Steward, Oliver T. Parkinson, Eva M. Schmidt, Nadine Lottmann, Marcel Freund, Vladimir Yarov-Yarovoy, Allan E. Rettie, Helmut Hanenberg
Publikováno v:
Schmidt, EM; Wiek, C; Parkinson, OT; Roellecke, K; Freund, M; Gombert, M; et al.(2015). Characterization of an additional splice acceptor site introduced into CYP4B1 in hominoidae during evolution. PLoS ONE, 10(9). doi: 10.1371/journal.pone.0137110. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2cf5f8fk
PloS one, vol 10, iss 9
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0137110 (2015)
PloS one, vol 10, iss 9
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0137110 (2015)
© 2015 Schmidt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21b3225e91d34e4aa21ae4b25cabda4
http://www.escholarship.org/uc/item/2cf5f8fk
http://www.escholarship.org/uc/item/2cf5f8fk
Autor:
Faraz Kazmi, Lois J. Haupt, David B. Buckley, Brandy L. Paris, Brian W. Ogilvie, Andrew Parkinson, Brian D. Smith, Oliver T. Parkinson, Sarah Leatherman
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(11)
In the present study, we conducted a retrospective analysis of 343 in vitro experiments to ascertain whether observed (experimentally determined) values of Ki for reversible cytochrome P450 (P450) inhibition could be reliably predicted by dividing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83577b8d91e0308ed5a55861dca943fc
https://pubmed.ncbi.nlm.nih.gov/26354951
https://pubmed.ncbi.nlm.nih.gov/26354951
Autor:
Oliver T. Parkinson, Mary F. Paine, James L. Allen, Janelle Y. Saulter, Michael Hall, David W. Boykin, James Edwin Hall, Greg J. Loewen, Richard R. Tidwell, Chad E. Stephens, Etsuko Usuki, Darryl C. Zeldin, Yen Ling Cheung, Arlene S. Bridges, Andrew Parkinson, Michael Zhuo Wang
Publikováno v:
Drug Metabolism and Disposition. 34:1985-1994
DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent antiparasitic diamidine DB75 [2,5-bis(4-amidinophenyl) furan] by sequential oxidative O-demethylation and reductive N-dehydroxylation reactions. Previous work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd79286dadf2572a54ca93760fabd03
https://doi.org/10.1124/dmd.106.010587
https://doi.org/10.1124/dmd.106.010587
4-Ipomeanol (IPO; 1-(3-furyl)-4-hydroxy-1-pentanone) is a furanoterpenoid toxin produced by sweet potatoes (Ipomoea batatas) in response to infection by the mold Fusariam solani (Doster et al., 1978). IPO was discovered following poisoning of bovine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c58973144ba24c436c96fcf60c5558
https://europepmc.org/articles/PMC3707440/
https://europepmc.org/articles/PMC3707440/
Publikováno v:
Chemical research in toxicology. 18(12)
The safe clinical use of phenytoin (PHT) is compromised by a drug hypersensitivity reaction, hypothesized to be due to bioactivation of the drug to a protein-reactive metabolite. Previous studies have shown PHT is metabolized to the primary phenol me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d628be64aaa4e27d684ab632aca4b17
https://pubmed.ncbi.nlm.nih.gov/16359177
https://pubmed.ncbi.nlm.nih.gov/16359177