Zobrazeno 1 - 10
of 308
pro vyhledávání: '"Oliver Smithies"'
Autor:
Masao Kakoki, Purushotham V. Ramanathan, John R. Hagaman, Ruriko Grant, Jennifer C. Wilder, Joan M. Taylor, J. Charles Jennette, Oliver Smithies, Nobuyo Maeda-Smithies
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Kakoki et al report a role for cyanocobalamin (B12) in preventing cardiomyopathy in type 1 diabetic mice, by reducing levels of reactive oxygen species and restoring IGF-1 levels via DNMT-SOCS1/3 signalling. The authors therefore propose B12 as a pro
Externí odkaz:
https://doaj.org/article/d458d85b19244ce497e74c59bd94bf79
Autor:
Arun Govindapillai, Adam Hotchkiss, Mark Baguma-Nibasheka, Robert A. Rose, Lucile Miquerol, Oliver Smithies, Nobuyo Maeda, Kishore B. S. Pasumarthi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Abstract Patients born with congenital heart defects frequently encounter arrhythmias due to defects in the ventricular conduction system (VCS) development. Although recent studies identified transcriptional networks essential for the heart developme
Externí odkaz:
https://doaj.org/article/6139798c940e48b69b339faa3dd76cf0
Autor:
Oliver Smithies, Jane Gitschier
Publikováno v:
PLoS Genetics, Vol 11, Iss 5, p e1005224 (2015)
Externí odkaz:
https://doaj.org/article/2e2aad03b74344ffa5f20053b9269f6a
Autor:
Anne-Cécile Huby, Maria-Pia Rastaldi, Kathleen Caron, Oliver Smithies, Jean-Claude Dussaule, Christos Chatziantoniou
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6721 (2009)
Proteinuria is a major marker of the decline of renal function and an important risk factor of coronary heart disease. Elevated proteinuria is associated to the disruption of slit-diaphragm and loss of podocyte foot processes, structural alterations
Externí odkaz:
https://doaj.org/article/cc321adff4ba4003bf5b4473e061057a
Publikováno v:
Cell Transplantation, Vol 18 (2009)
In view of the well-known phenomenon of trophoblast immune privilege, trophoblast stem cells (TSCs) might be expected to be immune privileged, which could be of interest for cell or gene therapies. Yet in the ectopic sites tested so far, TSC transpla
Externí odkaz:
https://doaj.org/article/03f8d6153a6947b98a7a04bb28bc215b
Autor:
Purushotham V. Ramanathan, Nobuyo Maeda-Smithies, Ruriko Grant, John R. Hagaman, Joan M. Taylor, Jennifer Wilder, Oliver Smithies, Masao Kakoki, J. Charles Jennette
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Patients with long-standing diabetes have a high risk for cardiac complications that is exacerbated by increased reactive oxygen species (ROS) production. We found that feeding cyanocobalamin (B12), a scavenger of superoxide, not only prevented but r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da927782f11cdf2a018c9b186b5c29c2
http://europepmc.org/articles/PMC8222371
http://europepmc.org/articles/PMC8222371
Publikováno v:
Small GTPases
Vascular resistance is a major determinant of BP and is controlled, in large part, by RhoA-dependent smooth muscle cell (SMC) contraction within small peripheral arterioles and previous studies from our lab indicate that GRAF3 is a critical regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b195a6c3d505cb043a70be385e2206e
https://doi.org/10.1080/21541248.2017.1375602
https://doi.org/10.1080/21541248.2017.1375602
Summary It is extremely important to measure quantitative parameters (e.g. plasma glucose, urinary albumin, etc.) in a way that minimizes the effects of any adventitious variables, such as seasonal changes, dietary differences, any differences in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42fbd6ac9a2cf7367ee5c1591fa47960
https://doi.org/10.17504/protocols.io.8fphtmn
https://doi.org/10.17504/protocols.io.8fphtmn
Autor:
Jessica C Rice, Oliver Smithies, Ruriko Grant, Feng Li, Yukako Kayashima, Michelle T Sun, Michael F. Almeida, Esther Y Lee, Joan M. Taylor, John R. Hagaman, Robin Siletzky, Edward Moreira Bahnson, J. Charles Jennette, Ben A. Bahr, Masao Kakoki, Nobuyo Maeda-Smithies
Engulfment and cell motility protein 1 (ELMO1) is part of a guanine nucleotide exchange factor for Ras-related C3 botulinum toxin substrate (Rac), and ELMO1 polymorphisms were identified to be associated with diabetic nephropathy in genome-wide assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46abf87b912c7ee75621adfe4edcbcac
https://europepmc.org/articles/PMC6629098/
https://europepmc.org/articles/PMC6629098/
Autor:
Mark Baguma-Nibasheka, Oliver Smithies, Lucile Miquerol, Adam Hotchkiss, Arun Govindapillai, Robert A. Rose, Kishore B.S. Pasumarthi, Nobuyo Maeda
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.6939. ⟨10.1038/s41598-018-25292-0⟩
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports, 2018, 8 (1), pp.6939. ⟨10.1038/s41598-018-25292-0⟩
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.6939. ⟨10.1038/s41598-018-25292-0⟩
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports, 2018, 8 (1), pp.6939. ⟨10.1038/s41598-018-25292-0⟩
Patients born with congenital heart defects frequently encounter arrhythmias due to defects in the ventricular conduction system (VCS) development. Although recent studies identified transcriptional networks essential for the heart development, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f53d6001e8be9ca380430301fe7ba0
https://hal.archives-ouvertes.fr/hal-01993728
https://hal.archives-ouvertes.fr/hal-01993728