Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Oliver Schwardt"'
Publikováno v:
CHIMIA, Vol 75, Iss 6, Pp 495-499 (2021)
Among the many molecular entities suitable for therapeutic use, peptides have emerged as a particularly attractive option for academic drug discovery and development. Their modular structure and extendibility, the availability of powerful and afforda
Externí odkaz:
https://doaj.org/article/e4722846a5e24cce8e8b18bdc5ff967a
Autor:
Beatrice Wagner, Florian P. C. Binder, Xiaohua Jiang, Tobias Mühlethaler, Roland C. Preston, Said Rabbani, Martin Smieško, Oliver Schwardt, Beat Ernst
Publikováno v:
Molecules, Vol 28, Iss 6, p 2595 (2023)
The d-GlcNAc moiety in sialyl Lewisx (sLex, 1) acts predominantly as a linker to position the d-Gal and the l-Fuc moieties in the bioactive spatial orientation. The hypothesis has been made that the NHAc group of GlcNAc pushes the fucose underneath t
Externí odkaz:
https://doaj.org/article/09c92691cdac462f95168204e153b667
Autor:
Priska Frei, Marleen Silbermann, Tobias Mühlethaler, Xiaohua Jiang, Oliver Schwardt, Rachel Hevey, Beat Ernst
Publikováno v:
ARKIVOC, Vol 2019, Iss 4, Pp 143-167 (2019)
Externí odkaz:
https://doaj.org/article/db33e44c9fde4421bf97c89ab238f961
Autor:
Beat Ernst, Oliver Schwardt, Stefanie Mesch, Matthias Wittwer, Gianluca Rossato, Angelo Vedani
Publikováno v:
CHIMIA, Vol 64, Iss 1-2 (2010)
The tetrasaccharide 4, a substructure of ganglioside GQ1b?, shows a remarkable affinity for the myelin-associated glycoprotein (MAG) and was therefore selected as starting point for a lead optimization program. In our search for structurally simplifi
Externí odkaz:
https://doaj.org/article/abe3761de1db40958725b8f5e9eddfc3
Publikováno v:
CHIMIA, Vol 60, Iss 4 (2006)
Sialylation catalyzed by sialyltransferases is one of the most interesting enzymatic glycosyl transfer reactions, since chemical sialylations usually give only low yields and lead to poor stereoselectivities. In the last decade, several bacterial sia
Externí odkaz:
https://doaj.org/article/2b6287ef1c7c4e9c93c34373f34dbeac
Publikováno v:
CHIMIA, Vol 60, Iss 1-2 (2006)
Research over the past two decades has uncovered numerous biological roles for carbohydrates, e.g. in cell adhesion processes, signal transduction, malignant transformation, or viral and bacterial cell-surface recognition. Carbohydrates and structura
Externí odkaz:
https://doaj.org/article/942686ee4ef2433a933ec1f799cd516b
Publikováno v:
CHIMIA, Vol 60, Iss 1-2 (2006)
The laboratory class Modern Drug Design at the Department of Pharmacy of the University of Basel offers the students a thorough training in modern drug design. First, antagonists for the Bradykinin B2 receptor are designed using state-of-the-art mode
Externí odkaz:
https://doaj.org/article/f6083d0ed74f4711a2a2b87f236157ff
Publikováno v:
CHIMIA, Vol 58, Iss 4 (2004)
Ganglioside GQ1b ? is the most potent antagonist of the Myelin-associated glycoprotein (MAG) identified so far. For the efficient synthesis of the partial structure of GQ1b ? and derivatives thereof, a chemo-enzymatic strategy using the ?(2?3)-sialyl
Externí odkaz:
https://doaj.org/article/5b4f71ceb4d64f4cb12a28bf1c0cbf80
Autor:
Tiago Bozzola, Mariafrancesca Scalise, Christer U. Larsson, Michael C. Newton-Vesty, Caterina Rovegno, Ankita Mitra, Jonathan Cramer, Weixiao Yuan Wahlgren, Partha Radhakrishnan Santhakumari, Richard E. Johnsson, Oliver Schwardt, Beat Ernst, Rosmarie Friemann, Renwick C. J. Dobson, Cesare Indiveri, Jenny Schelin, Ulf J. Nilsson, Ulf Ellervik
Publikováno v:
ACS Chemical Biology. 17:1890-1900
Antibiotic resistance is a major worldwide concern, and new drugs with mechanistically novel modes of action are urgently needed. Here, we report the structure-based drug design, synthesis, and evaluation in vitro and in cellular systems of sialic ac
Autor:
Benedetta Girardi, Martina Manna, Sjors Van Klaveren, Tihomir Tomašič, Žiga Jakopin, Hakon Leffler, Ulf J. Nilsson, Daniel Ricklin, Janez Mravljak, Oliver Schwardt, Marko Anderluh
Publikováno v:
ChemMedChem. 17