Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Oliver Rocks"'
Autor:
Fabian Freiberg, Meghna Thakkar, Wiebke Hamann, Jacobo Lopez Carballo, Rene Jüttner, Felizia K. Voss, Peter M. Becher, Dirk Westermann, Carsten Tschöpe, Arnd Heuser, Oliver Rocks, Robert Fischer, Michael Gotthardt
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 3, Pp 643-652 (2023)
Heart attack: Inhibiting cell contact protein may limit damage During a heart attack the death of heart muscle cells causes lesions that transform into fibrotic tissue. Restricting the damage is critical, as mamalian heart muslce does not regenerate.
Externí odkaz:
https://doaj.org/article/fc2561fd24ba4e1d9192ae9c018ef5fa
Autor:
Paul Markus Müller, Oliver Rocks
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101705- (2022)
Summary: Rho family GTPases are central regulators of cytoskeletal dynamics controlled by guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). This protocol presents a workflow for a robust high-throughput compatibl
Externí odkaz:
https://doaj.org/article/09f0d64642bb4e12937be73a95e5acec
Autor:
Rebecca L. Eccles, Maciej T. Czajkowski, Carolin Barth, Paul Markus Müller, Erik McShane, Stephan Grunwald, Patrick Beaudette, Nora Mecklenburg, Rudolf Volkmer, Kerstin Zühlke, Gunnar Dittmar, Matthias Selbach, Annette Hammes, Oliver Daumke, Enno Klussmann, Sylvie Urbé, Oliver Rocks
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of
Externí odkaz:
https://doaj.org/article/4b603724ee39452aa970f9812ba07050
Autor:
Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E. Wanker
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these prot
Externí odkaz:
https://doaj.org/article/c05c3467f02d4df0b4320632445b06fa
Autor:
Katharina Schrade, Jessica Tröger, Adeeb Eldahshan, Kerstin Zühlke, Kamal R Abdul Azeez, Jonathan M Elkins, Martin Neuenschwander, Andreas Oder, Mohamed Elkewedi, Sarah Jaksch, Karsten Andrae, Jinliang Li, Joao Fernandes, Paul Markus Müller, Stephan Grunwald, Stephen F Marino, Tanja Vukićević, Jenny Eichhorst, Burkhard Wiesner, Marcus Weber, Michael Kapiloff, Oliver Rocks, Oliver Daumke, Thomas Wieland, Stefan Knapp, Jens Peter von Kries, Enno Klussmann
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191423 (2018)
Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane. The membrane
Externí odkaz:
https://doaj.org/article/90f46ed5dd9245e28b25eb7c6c87fe03
Autor:
Lennart Brandenburg, Philipp Mertins, Kiara Freitag, Jakobus van Unen, Vivian Nguyen, Celina Wortmann, Paul Markus Mueller, Oliver Popp, Trendelina Rrustemi, Oliver Rocks, Lisa Spatt, Brett Larsen, Juliane Rademacher, Tony Pawson, Richard D. Bagshaw, Patricia Pascual-Vargas, Rebecca L Eccles, Olivier Pertz, Maciej T. Czajkowski, Carolin Barth, Evangelia Petsalaki, Monika Tucholska, Robert William Welke, Sunqu Zhang, Philipp Trnka, Geraldine Mbamalu, Louise E Heinrich, Anne-Claude Gingras, Marta Sanchez-Castro, Karen Colwill, Frederick P. Roth, Girolamo Giudice, Keziban M. Alp, Chris Bakal
Publikováno v:
Nature Cell Biology. 22:498-511
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs). How Rho signalling patterns are established in dynamic ce
Autor:
Brandenburg L, Rademacher J, Anne-Claude Gingras, Celina Wortmann, Welke R, Marta Sanchez-Castro, Philip Mertins, Karen Colwill, Maciej T. Czajkowski, Oliver Popp, Olivier Pertz, Sunqu Zhang, Freitag K, Brett Larsen, Rick Bagshaw, Frederick P. Roth, Nguyen, Monika Tucholska, Girolamo Giudice, Trendelina Rrustemi, Lisa Spatt, Carolin Barth, Rebecca L Eccles, Geraldine Mbamalu, Philipp Trnka, Heinrich Le, Evangelia Petsalaki, Paul Muller, Keziban M. Alp, Oliver Rocks, Tony Pawson, Chris Bakal
Rho GTPases control cell morphogenesis and thus fundamental processes in all eukaryotes. They are regulated by 145 RhoGEF and RhoGAP multi-domain proteins in humans. How the Rho signaling system is organized to generate localized responses in cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b79919d6e97e1ffa16654b6bd92030e
https://doi.org/10.1101/354316
https://doi.org/10.1101/354316
Autor:
Claudia Abou-Ajram, Rebecca L Eccles, Verena Thormann, Oliver Rocks, Dorothee Dormann, Victoria Casado-Medrano, Nouhad Benlasfer, Saskia Hutten, Ulrich Stelzl, Christian L. Heine, Jonathan Woodsmith
Publikováno v:
Life Science Alliance
Extensively modifiable arrays of clustered arginines in a large set of human proteins function as regulatory protein interaction platforms. Quantitative immunoprecipitation assays defined two distinct cumulative binding mechanisms operating across an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0559c8561269a3f5225736768cd68a0b
Autor:
Tony Pawson, Anne-Claude Gingras, Richard D. Bagshaw, Evangelia Petsalaki, Elizabeth J. Gray, Melissa M. Stacey, Oliver Rocks, D. Andrew James
Publikováno v:
Journal of Biological Chemistry. 289:35397-35408
SH2D5 is a mammalian-specific, uncharacterized adaptor-like protein that contains an N-terminal phosphotyrosine-binding domain and a C-terminal Src homology 2 (SH2) domain. We show that SH2D5 is highly enriched in adult mouse brain, particularly in P
Autor:
David Schwefel, Oliver Daumke, Chris Fröhlich, Jason A. Mears, Eva Rosenbaum, Katja Faelber, Oliver Rocks, Stefan Grabiger
Publikováno v:
The EMBO Journal. 32:1280-1292
Dynamin 1-like protein (DNM1L) mediates fission of mitochondria and peroxisomes, and dysfunction of DNM1L has been implicated in several neurological disorders. To study the molecular basis of mitochondrial remodelling, we determined the crystal stru