The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation.

Autor: Brian B Tuch, Quinn M Mitrovich, Oliver R Homann, Aaron D Hernday, Cinna K Monighetti, Francisco M De La Vega, Alexander D Johnson

Publikováno v: PLoS Genetics, Vol 6, Iss 8, p e1001070 (2010)

The differentiation of cells into distinct cell types, each of which is heritable for many generations, underlies many biological phenomena. White and opaque cells of the fungal pathogen Candida albicans are two such heritable cell types, each though

Externí odkaz: https://doaj.org/article/615cf890f5d94e6a882187ded0329f96

Biofilm matrix regulation by Candida albicans Zap1.

Autor: Clarissa J Nobile, Jeniel E Nett, Aaron D Hernday, Oliver R Homann, Jean-Sebastien Deneault, Andre Nantel, David R Andes, Alexander D Johnson, Aaron P Mitchell

Publikováno v: PLoS Biology, Vol 7, Iss 6, p e1000133 (2009)

A biofilm is a surface-associated population of microorganisms embedded in a matrix of extracellular polymeric substances. Biofilms are a major natural growth form of microorganisms and the cause of pervasive device-associated infection. This report

Externí odkaz: https://doaj.org/article/ad136d62b4264889b5cada28f1c3bc01

A Conserved Transcriptional Regulator Governs Fungal Morphology in Widely Diverged Species

Autor: Christopher W. Cain, Matthew B. Lohse, Anita Sil, Oliver R. Homann, Alexander D. Johnson

Publikováno v: Genetics. 190:511-521

Fungi exhibit a large variety of morphological forms. Here, we examine the functions of a deeply conserved regulator of morphology in three fungal species: Saccharomyces cerevisiae, Candida albicans, and Histoplasma capsulatum. We show that, despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f448852f254dbea7061e6b65f483cd1
https://doi.org/10.1534/genetics.111.134080

Biofilm matrix regulation by Candida albicans Zap1

Autor: Jeniel E. Nett, André Nantel, Alexander D. Johnson, Jean-Sebastien Deneault, Oliver R. Homann, Aaron D. Hernday, David R. Andes, Clarissa J. Nobile, Aaron P. Mitchell

Publikováno v: PLoS Biology
Nobile, CJ; Nett, JE; Hernday, AD; Homann, OR; Deneault, JS; Nantel, A; et al.(2009). Biofilm matrix regulation by Candida albicans Zap1. PLoS Biology, 7(6). doi: 10.1371/journal.pbio.1000133. UC Merced: Retrieved from: http://www.escholarship.org/uc/item/0tr0j2m5
PLoS biology, vol 7, iss 6
PLoS Biology, Vol 7, Iss 6, p e1000133 (2009)

The zinc-responsive transcription factor Zap1 has a striking role in fungal biofilm formation and is reported to regulate matrix formation.
A biofilm is a surface-associated population of microorganisms embedded in a matrix of extracellular poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4d0f30a681a5a0d871d486a6c0563f
http://europepmc.org/articles/PMC2688839

Harnessing Natural Diversity to Probe Metabolic Pathways

Autor: Susan Lindquist, Jeffrey M. Becker, Oliver R. Homann, Houjian Cai

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 1, Iss 6, p e80 (2005)

Analyses of cellular processes in the yeast Saccharomyces cerevisiae rely primarily upon a small number of highly domesticated laboratory strains, leaving the extensive natural genetic diversity of the model organism largely unexplored and unexploite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ba45c00b808d6a858977baeb064f2e
https://doi.org/10.1371/journal.pgen.0010080