Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Oliver Pusch"'
Autor:
Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E. Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer
Publikováno v:
European Journal of Histochemistry, Vol 68, Iss 1 (2024)
During the aging process, cells can enter cellular senescence, a state in which cells leave the cell cycle but remain viable. This mechanism is thought to protect tissues from propagation of damaged cells and the number of senescent cells has been sh
Externí odkaz:
https://doaj.org/article/ec659ccaa2ec4d6fa649e2bac1dbd167
Autor:
Maria Butylina, Katharina Wahl-Figlash, Michael Kothmayer, Katharina Gelles, Oliver Pusch, Peter Pietschmann
Publikováno v:
Biology, Vol 12, Iss 10, p 1305 (2023)
Introduction: Osteoarthritis is a classical age-related disease, which affects millions of patients worldwide. To further understand the pathophysiology and to develop therapeutic strategies for this disease, animal models play a significant role. No
Externí odkaz:
https://doaj.org/article/1ad522c0bc0f4f4687cd2aa6d6c83843
Autor:
Gordin Zupkovitz, Julijan Kabiljo, Michael Kothmayer, Katharina Schlick, Christian Schöfer, Sabine Lagger, Oliver Pusch
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Erosion of the epigenetic DNA methylation landscape is a widely recognized hallmark of aging. Emerging advances in high throughput sequencing techniques, in particular DNA methylation data analysis, have resulted in the establishment of precise human
Externí odkaz:
https://doaj.org/article/1ff5f76daab54cc8b316f2d69e3e5779
Autor:
Maria Butylina, Ursula Föger-Samwald, Sonja Gamsjaeger, Katharina Wahl-Figlash, Michael Kothmayer, Eleftherios P. Paschalis, Oliver Pusch, Peter Pietschmann
Publikováno v:
Gerontology. 68:1415-1427
Introduction: Osteoporosis is a frequent age-related disease, which affects millions of people worldwide. Despite significant progress in the treatment of the disease, a high number of patients still are underdiagnosed and undertreated. Therefore, no
Autor:
Maria, Butylina, Ursula, Föger-Samwald, Sonja, Gamsjaeger, Katharina, Wahl-Figlash, Michael, Kothmayer, Eleftherios P, Paschalis, Oliver, Pusch, Peter, Pietschmann
Publikováno v:
Gerontology. 68(12)
Osteoporosis is a frequent age-related disease, which affects millions of people worldwide. Despite significant progress in the treatment of the disease, a high number of patients still are underdiagnosed and undertreated. Therefore, novel animal mod
Publikováno v:
Gene expression patterns : GEP. 33
The founding member of the sirtuin family, yeast Sir2, was the first evolutionarily conserved gene to be identified as a regulator of longevity. Sirtuins constitute a protein family of metabolic sensors, translating changes in NAD + levels into adapt
Autor:
Shaun Webb, Kashyap Chhatbar, Bartlomiej Waclaw, Bernard Ramsahoye, Miao Yu, Justyna Cholewa-Waclaw, Ruth Shah, Oliver Pusch, Adrian Bird, Philip Greulich
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Cholewa-Waclaw, J, Shah, R, Webb, S, Chhatbar, K, Ramsahoye, B, Pusch, O, Yu, M, Greulich, P, Waclaw, B & Bird, A P 2019, ' Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic ', Proceedings of the National Academy of Sciences, vol. 116, no. 30, pp. 14995-15000 . https://doi.org/10.1073/pnas.1903549116
Cholewa-Waclaw, J, Shah, R, Webb, S, Chhatbar, K, Ramsahoye, B, Pusch, O, Yu, M, Greulich, P, Waclaw, B & Bird, A P 2019, ' Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic ', Proceedings of the National Academy of Sciences, vol. 116, no. 30, pp. 14995-15000 . https://doi.org/10.1073/pnas.1903549116
Significance We introduce an interdisciplinary approach to understanding global modulation of gene expression in mammalian cells. Conventional transcription factors target a limited subset of genes, whereas global modulators bind the genome broadly.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef4156f6c8804bad8fc11e3b00c8a20
Autor:
Gordin Zupkovitz, David Martin, Christian Schöfer, Oliver Pusch, Astrid Hagelkruys, Christian Seiser, Marianne Steiner, Sabine Lagger
Publikováno v:
Histochemistry and Cell Biology
Aging is associated with profound changes in the epigenome, resulting in alterations of gene expression, epigenetic landscape, and genome architecture. Class I Histone deacetylases (HDACs), consisting of HDAC1, HDAC2, HDAC3, and HDAC8, play a major r
Autor:
Sylvia Laffer, Luc Snyers, Klara Weipoltshammer, Renate Erhart, Christian Schöfer, Oliver Pusch
Publikováno v:
European journal of cell biology. 97(1)
The human LEM-domain protein family is involved in fundamental aspects of nuclear biology. The LEM-domain interacts with the barrier-to-autointegration factor (BAF), which itself binds DNA. LEM-domain proteins LAP2, emerin and MAN1 are proteins of th
Autor:
Ivo L. Hofacker, Andrea Tanzer, Stefan Badelt, Sandy Schopoff, Florian Huber, Michael F. Jantsch, Oliver Pusch, Mansoureh Tajaddod, Konstantin Licht, Michael T. Wolfinger, Michael P Janisiw
Publikováno v:
Genome Biology
Background Short interspersed elements (SINEs) represent the most abundant group of non-long-terminal repeat transposable elements in mammalian genomes. In primates, Alu elements are the most prominent and homogenous representatives of SINEs. Due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a9fb2f2abba246a4d2a8d70e1dd149
https://phaidra.univie.ac.at/o:519345
https://phaidra.univie.ac.at/o:519345