Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Oliver Pilgram"'
Autor:
Nicholas van Eijk, Luna C. Schmacke, Torsten Steinmetzer, Oliver Pilgram, Miklós Poór, Erzsébet Pászti-Gere
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115761- (2023)
The outbreak of coronavirus disease 2019 (COVID-19) pandemic strongly stimulated the development of small molecule antivirals selectively targeting type II transmembrane serine proteases (TTSP), required for the host-cell entry of numerous viruses. A
Externí odkaz:
https://doaj.org/article/2cba99daeb6c428d8c10277c3f18aaa3
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 659-668 (2021)
Human intestinal epithelial cell line-6 (HIEC-6) cells and primary human hepatocytes (PHHs) were treated with 3-amidinophenylalanine-derived inhibitors of trypsin-like serine proteases for 24 hours. It was proven that treatment with MI-1900 and MI-19
Externí odkaz:
https://doaj.org/article/04576f774d394750bc7c23a3c73a1a73
Autor:
Erzsébet Pászti-Gere, Anna Szentkirályi, Zsófia Fedor, Gábor Nagy, Zoltán Szimrók, Zoltán Pászti, Anna Pászti, Oliver Pilgram, Torsten Steinmetzer, Slávka Bodnárová, Eszter Fliszár-Nyúl, Miklós Poór
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112513- (2022)
The interactions of four sulfonylated Phe(3-Am)-derived inhibitors (MI-432, MI-463, MI-482 and MI-1900) of type II transmembrane serine proteases (TTSP) such as transmembrane protease serine 2 (TMPRSS2) were examined with serum albumin and cytochrome
Externí odkaz:
https://doaj.org/article/7063944e2fe8465e93ca323f56eaf882
Autor:
Zsófia Fedor, Anna Szentkirályi-Tóth, Gábor Nagy, Zoltán Szimrók, Eszter Varga, Anna Pászti, Zoltán Pászti, Ákos Jerzsele, Oliver Pilgram, Torsten Steinmetzer, Gábor Mátis, Zsuzsanna Neogrády, Erzsébet Pászti-Gere
Publikováno v:
Veterinary Sciences, Vol 9, Iss 4, p 156 (2022)
In vitro models of animals vulnerable to SARS-CoV-2 infection can support the characterization of effective antiviral drugs, such as synthetic inhibitors of the transmembrane protease serine 2 (TMPRSS2). Changes in cytochrome P450 (CYP) 1A2 activitie
Externí odkaz:
https://doaj.org/article/2daa9330bc4048fdbcac8964c25dd57b
Autor:
Karen Singers Eiskjær Johansen, Martin Tolstrup, Frederik Dagnæs-Hansen, Alexander N. Zelikin, Kaja Zuwala, Anton A. A. Smith, Oliver Pilgram
Publikováno v:
Smith, A A A, Zuwala, K, Pilgram, O, Johansen, K S E, Tolstrup, M, Dagnæs-Hansen, F & Zelikin, A N 2016, ' Albumin–Polymer–Drug Conjugates: Long Circulating, High Payload Drug Delivery Vehicles ', ACS Macro Letters, vol. 5, pp. 1089-1094 . https://doi.org/10.1021/acsmacrolett.6b00544
Albumin is an exquisite tool of nature used in biomedicine to achieve long blood residence time for drugs, but the payload it can carry is typically limited to one molecule per protein. In contrast, synthetic macromolecular prodrugs contain multiple
Publikováno v:
Journal of Medicinal Chemistry. 63:1445-1472
Hyperfibrinolytic situations can lead to life-threatening bleeding, especially during cardiac surgery. The approved antifibrinolytic agents such as tranexamic acid, ε-aminocaproic acid, 4-aminomethylbenzoic acid, and aprotinin were developed in the
Autor:
Oliver Pilgram, Aline Keils, Gerrit E. Benary, Janis Müller, Stefan Merkl, Sandrine Ngaha, Simon Huber, Florent Chevillard, Anne Harbig, Viktor Magdolen, Andreas Heine, Eva Böttcher-Friebertshäuser, Torsten Steinmetzer
Publikováno v:
European Journal of Medicinal Chemistry. 238:114437
A rational structure-based approach was employed to develop novel 3-amidinophenylalanine-derived matriptase inhibitors with improved selectivity against thrombin and factor Xa. Of all 23 new derivatives, several monobasic inhibitors exhibit high matr
Autor:
Olga Dolnik, Eva Böttcher-Friebertshäuser, Torsten Steinmetzer, Dorothea Bestle, Cornelius Rohde, Wolfgang Garten, Stephan Becker, Thuy Van Lam van, Kornelia Hardes, Markus Eickmann, Hannah Limburg, David A. Stein, Miriam Ruth Heindl, Hans-Dieter Klenk, Oliver Pilgram, Hong M. Moulton
In December 2019, a novel coronavirus named SARS-CoV-2 first reported in Wuhan, China, emerged and rapidly spread to numerous other countries globally, causing the current pandemic. SARS-CoV-2 causes acute infection of the respiratory tract (COVID-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196228de1e7598635c481cf65c4cd7ba
https://doi.org/10.1101/2020.04.15.042085
https://doi.org/10.1101/2020.04.15.042085
Autor:
Alicia López-Andarias, Carolina Egler-Lucas, Jens-Peter Neus, Carlos Romero-Nieto, Florian Gebert, Oliver Pilgram
Publikováno v:
Angewandte Chemie International Edition. 54:15872-15875
Phosphorus-based heterocycles provide access to materials with properties that are inaccessible from all-carbon architectures. The unique hybridization of phosphorus gives rise to electron-accepting capacities, a large variety of coordination reactio
Autor:
Carlos Romero-Nieto, Florian Gebert, Alicia López-Andarias, Jens-Peter Neus, Carolina Egler-Lucas, Oliver Pilgram
Publikováno v:
Angewandte Chemie. 127:16098-16102
Phosphorbasierte Heterozyklen ermoglichen Materialeigenschaften, die durch reine Kohlenstoffstrukturen nicht zuganglich sind. Die einzigartige Hybridisierung des Phosphors fuhrt zu Elektronen-akzeptierenden Eigenschaften, einer grosen Zahl an Koordin