Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Oliver Phipps"'
Autor:
Aditi Kumar, Niall Galbraith, Hafid O. Al-Hassi, Manushri Jain, Oliver Phipps, Jeffrey Butterworth, Helen Steed, John McLaughlin, Matthew J. Brookes
Publikováno v:
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Bile acid diarrhoea (BAD) can be severely debilitating and negatively affect patients’ quality of life (QoL). We carried out a multi-centre prospective study exploring QoL outcomes in patients with BAD after treatment with coles
Externí odkaz:
https://doaj.org/article/9e395c22e5a74b818491cf5f56ab2995
Autor:
Aditi Kumar, Hafid O. Al-Hassi, Manushri Jain, Oliver Phipps, Clare Ford, Rousseau Gama, Helen Steed, Jeffrey Butterworth, John McLaughlin, Niall Galbraith, Matthew J. Brookes, Lauren E. Hughes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract This study examines the validity of measuring faecal bile acids (FBA) in a single stool sample as a diagnostic tool for bile acid diarrhoea (BAD) by direct comparison to the 75selenium-homotaurocholic acid (SeHCAT) scan. A prospective observ
Externí odkaz:
https://doaj.org/article/19d68fedaf0a4562a01e7e23152a03bb
Autor:
Hafid O. Al-Hassi, Oliver Ng, Rayko Evstatiev, Manel Mangalika, Natalie Worton, Manuela Jambrich, Vineeta Khare, Oliver Phipps, Barrie Keeler, Christoph Gasche, Austin G. Acheson, Matthew J. Brookes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Oral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth.
Externí odkaz:
https://doaj.org/article/421c6c1e64334c10b8d8919f20611200
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2022 (2022)
Background. Bile acids help maintain the physiological balance of the gut microbiome and the integrity of the intestinal epithelial barrier. Similarly, intestinal bacteria play a major role in bile acid metabolism as they are involved in crucial biot
Externí odkaz:
https://doaj.org/article/9bd736de4b574cc296161fbff52f7e84
Autor:
Oliver Phipps, Mohammed N. Quraishi, Edward A. Dickson, Helen Steed, Aditi Kumar, Austin G. Acheson, Andrew D. Beggs, Matthew J. Brookes, Hafid Omar Al-Hassi
Publikováno v:
Microorganisms, Vol 9, Iss 5, p 1108 (2021)
This study aims to determine differences in the on- and off-tumor microbiota between patients with right- and left-sided colorectal cancer. Microbiome profiling of tumor and tumor-adjacent biopsies from patients with right-sided (n = 17) and left-sid
Externí odkaz:
https://doaj.org/article/4d3edb11b6c64583870fcdde701634a2
Autor:
Oliver Phipps, Hafid O. Al-Hassi, Mohammed N. Quraishi, Edward A. Dickson, Jonathan Segal, Helen Steed, Aditi Kumar, Austin G. Acheson, Andrew D. Beggs, Matthew J. Brookes
Publikováno v:
Cancers, Vol 13, Iss 6, p 1341 (2021)
Iron deficiency anemia is a common complication of colorectal cancer and may require iron therapy. Oral iron can increase the iron available to gut bacteria and may alter the colonic microbiota. We performed an intervention study to compare oral and
Externí odkaz:
https://doaj.org/article/d010d72603134413ab6f6c55956a7738
Publikováno v:
Nutrients, Vol 12, Iss 9, p 2512 (2020)
Perturbations of the colonic microbiota can contribute to the initiation and progression of colorectal cancer, leading to an increase in pathogenic bacteria at the expense of protective bacteria. This can contribute to disease through increasing carc
Externí odkaz:
https://doaj.org/article/f79b015fd3e6470faf3a8b2dd5236758
Autor:
Matthew J Brookes, Oliver Phipps, Natalie Worton, Rayko Evstatiev, Manel Mangalika, BD Keeler, Austin G. Acheson, HO Al-Hassi, Vineeta Khare, Manuela Jambrich, Oliver Ng, Christoph Gasche
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Oral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorecta
Publikováno v:
Nutrition Reviews. 79:88-97
Excessive gut luminal iron contributes to the initiation and progression of colorectal cancer. However, emerging evidence suggests that reduced iron intake and low systemic iron levels are also associated with the pathogenesis of colorectal cancer. T
Autor:
Andrew D Beggs, Oliver Phipps, Austin G. Acheson, Mohammed Nabil Quraishi, Edward A Dickson, Aditi Kumar, HO Al-Hassi, Helen Steed, Matthew J Brookes, Jonathan Segal
Publikováno v:
Cancers
Volume 13
Issue 6
Cancers, Vol 13, Iss 1341, p 1341 (2021)
Volume 13
Issue 6
Cancers, Vol 13, Iss 1341, p 1341 (2021)
Simple Summary Anemia is commonly associated with colorectal cancer and often requires intervention with therapeutic iron. However, iron is required for growth by the majority of colonic bacteria, leading to competition for free luminal iron. Hence,