Výsledky vyhledávání - "Oliver Pötz"

Akademický článek

Sensitizing cholangiocarcinoma to chemotherapy by inhibition of the drug-export pump MRP3

Autor: Maitane Asensio, Oscar Briz, Elisa Herraez, Laura Perez-Silva, Ricardo Espinosa-Escudero, Diego Bueno-Sacristan, Ana Peleteiro-Vigil, Helen Hammer, Oliver Pötz, Onat Kadioglu, Jesus M. Banales, Maria L. Martinez-Chantar, Matias A. Avila, Rocio I.R. Macias, Thomas Efferth, Jose J.G. Marin, Elisa Lozano

Publikováno v: Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117533- (2024)

Aims: Drug export through ABC proteins hinders cancer response to chemotherapy. Here, we have evaluated the relevance of MRP3 (ABCC3) in cholangiocarcinoma (CCA) as a potential target to overcome drug resistance. Methods: Gene expression was analyzed

Externí odkaz: https://doaj.org/article/0203ec3ee8bd4fc3ac082125978b51ae

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Akademický článek

Immunoaffinity proteomics for kidney injury biomarkers in male beagle dogs

Autor: Wael Naboulsi, Hannes Planatscher, Felix F. Schmidt, Andreas Steinhilber, Thomas O. Joos, Adeyemi O. Adedeji, James Eric McDuffie, Oliver Pötz

Publikováno v: EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 180-197 (2024)

Drug-induced kidney injury (DIKI) is a cause of drug development failure. Dogs represent a common non-rodent animal model in pre-clinical safety studies; however, biomarker assays for detecting nephrotoxicity in dogs are limited. To identify novel pr

Externí odkaz: https://doaj.org/article/0d5cf4ccd8aa424fa54114b5192b6cf7

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Akademický článek

Sensitization of cholangiocarcinoma cells to chemotherapy through BCRP inhibition with β-caryophyllene oxide

Autor: Sara Ortiz-Rivero, Ana Peleteiro-Vigil, Lorena Abete, Elisa Lozano, Helen S. Hammer, Silvia Di Giacomo, Mar Abad, Loreto Boix, Alejandro Forner, Maria Reig, Rocio I.R. Macias, Oliver Pötz, Jose J.G. Marin, Oscar Briz

Publikováno v: Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116038- (2024)

Cholangiocarcinomas (CCAs) are cancers originated in the biliary tree, which are characterized by their high mortality and marked chemoresistance, partly due to the activity of ATP-binding cassette (ABC) export pumps, whose inhibition has been propos

Externí odkaz: https://doaj.org/article/b4843168fecc49a9b5509ab1be898085

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Akademický článek

Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

Autor: Henning Kempf, Ruth Olmer, Alexandra Haase, Annika Franke, Emiliano Bolesani, Kristin Schwanke, Diana Robles-Diaz, Michelle Coffee, Gudrun Göhring, Gerald Dräger, Oliver Pötz, Thomas Joos, Erik Martinez-Hackert, Axel Haverich, Falk F. R. Buettner, Ulrich Martin, Robert Zweigerdt

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Differentiation of human pluripotent stem cells (hPSC) mimics aspects of embryonic developmentin vitrobut is poorly understood. Here, the authors identify bulk cell density as a key parameter directing transition from pluripotency to primitive streak

Externí odkaz: https://doaj.org/article/ea239ac1a9674180890cc009aad95741

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Akademický článek

A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to Vemurafenib

Autor: Tobias Sinnberg, Elena Makino, Marcel A. Krueger, Ana Velic, Boris Macek, Ulrich Rothbauer, Nicola Groll, Oliver Pötz, Stefan Czemmel, Heike Niessner, Friedegund Meier, Kristian Ikenberg, Claus Garbe, Birgit Schittek

Publikováno v: EBioMedicine, Vol 8, Iss C, Pp 132-149 (2016)

Acquired resistance to second generation BRAF inhibitors (BRAFis), like vemurafenib is limiting the benefits of long term targeted therapy for patients with malignant melanomas that harbor BRAF V600 mutations. Since many resistance mechanisms have be

Externí odkaz: https://doaj.org/article/2e1b05dd00f64c71ac1a7708866ee974

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