Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Oliver P, Ernst"'
Autor:
Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G. Govorunova, Oleg A. Sineshchekov, Yumei Wang, Lei Zheng, Éva Bertalan, Ana-Nicoleta Bondar, Azam Askari, Leonid S. Brown, John L. Spudich, Oliver P. Ernst
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the absence of the canonical tetrameric K+ selectivity filter found univ
Externí odkaz:
https://doaj.org/article/4df751c792bb444bae38a92d509b0e3d
Autor:
Jessica E. Besaw, Jörg Reichenwallner, Paolo De Guzman, Andrejs Tucs, Anling Kuo, Takefumi Morizumi, Koji Tsuda, Adnan Sljoka, R. J. Dwayne Miller, Oliver P. Ernst
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Within the microbial rhodopsin family, heliorhodopsins (HeRs) form a phylogenetically distinct group of light-harvesting retinal proteins with largely unknown functions. We have determined the 1.97 Å resolution X-ray crystal structure of Th
Externí odkaz:
https://doaj.org/article/699e564600764ed9b8944a7e60ca6556
Autor:
Jennifer L. Wierman, Olivier Paré-Labrosse, Antoine Sarracini, Jessica E. Besaw, Michael J. Cook, Saeed Oghbaey, Hazem Daoud, Pedram Mehrabi, Irina Kriksunov, Anling Kuo, David J. Schuller, Scott Smith, Oliver P. Ernst, Doletha M. E. Szebenyi, Sol M. Gruner, R. J. Dwayne Miller, Aaron D. Finke
Publikováno v:
IUCrJ, Vol 6, Iss 2, Pp 305-316 (2019)
A fixed-target approach to high-throughput room-temperature serial synchrotron crystallography with oscillation is described. Patterned silicon chips with microwells provide high crystal-loading density with an extremely high hit rate. The microfocus
Externí odkaz:
https://doaj.org/article/62d99d10a82048b68c066a3bd5f818ec
Autor:
Shuya Kate Huang, Louis-Philippe Picard, Rima S. M. Rahmatullah, Aditya Pandey, Ned Van Eps, Roger K. Sunahara, Oliver P. Ernst, Adnan Sljoka, R. Scott Prosser
Publikováno v:
Nature Structural & Molecular Biology. 30:502-511
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33be834828356986fd28531a072be66
https://doi.org/10.1038/s41594-023-00957-1
https://doi.org/10.1038/s41594-023-00957-1
Autor:
Libin Ye, Chris Neale, Adnan Sljoka, Brent Lyda, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Régis Pomès, Angel E. García, Oliver P. Ernst, Roger K. Sunahara, R. Scott Prosser
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
G protein-coupled receptors (GPCRs) are membrane receptors and are important drug targets, whose regulation by cations is poorly understood. Here authors use NMR to elucidate effects of cations on functional states of the GPCR, adenosine A2Areceptor
Externí odkaz:
https://doaj.org/article/25e0679825f24b93877531f883a95c68
Autor:
Birgit Ploier, Lydia N. Caro, Takefumi Morizumi, Kalpana Pandey, Jillian N. Pearring, Michael A. Goren, Silvia C. Finnemann, Johannes Graumann, Vadim Y. Arshavsky, Jeremy S. Dittman, Oliver P. Ernst, Anant K. Menon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Retinitis pigmentosa is often caused by mutations that affect the activity or transport of rhodopsin, but some mutations cause disease even though an apparently functional protein is produced. Here the authors show that three such enigmatic mutants r
Externí odkaz:
https://doaj.org/article/94c82e6657484b44baee46822dc7c91b
Autor:
Asma Sarguroh, Ehsan Nikbin, Jessica E Besaw, Hazem Daoud, Robert A McLeod, Jane Y Howe, Oliver P Ernst, R J Dwayne Miller
Publikováno v:
Microscopy and Microanalysis. 28:356-358
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d379106768c198968b475da89e0d12ed
https://doi.org/10.1017/s1431927622002173
https://doi.org/10.1017/s1431927622002173
Autor:
Oliver P. Ernst, Megan J. Maher
Publikováno v:
Current Opinion in Structural Biology. 69:vi-viii
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea386a5ed59194c0022d485ed4756fe5
https://doi.org/10.1016/j.sbi.2021.06.014
https://doi.org/10.1016/j.sbi.2021.06.014
Publikováno v:
The Journal of Biological Chemistry
The ubiquitin-proteasome-system (UPS) fulfills an essential role in regulating protein homeostasis by spatially and temporally controlling proteolysis in an ATP- and ubiquitin-dependent manner. However, the localization of proteasomes is highly varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ed9da8db87e25a5123782897fabe63
https://pubmed.ncbi.nlm.nih.gov/35636514
https://pubmed.ncbi.nlm.nih.gov/35636514
Autor:
Oliver P. Ernst, Przemyslaw Miszta, Dorothy Yanling Zhao, Julia Mahamid, Takefumi Morizumi, Matthias Pöge, Slawomir Filipek, Sahil Gulati, Wolfgang Baumeister, Jianye Zhang, Ned Van Eps, Jürgen M. Plitzko, Krzysztof Palczewski
Publikováno v:
J Biol Chem
The Journal of biological chemistry, vol 294, iss 39
The Journal of biological chemistry, vol 294, iss 39
Imaging of rod photoreceptor outer-segment disc membranes by atomic force microscopy and cryo-electron tomography has revealed that the visual pigment rhodopsin, a prototypical class A G protein-coupled receptor (GPCR), can organize as rows of dimers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bf54c4ea13a66b24452d68d6c27175
https://doi.org/10.1074/jbc.ra119.010089
https://doi.org/10.1074/jbc.ra119.010089