Membrane Dynamics and Organization of the Phagocyte NADPH Oxidase in PLB-985 Cells

Autor: Jérémy Joly, Elodie Hudik, Sandrine Lecart, Dirk Roos, Paul Verkuijlen, Dominik Wrona, Ulrich Siler, Janine Reichenbach, Oliver Nüsse, Sophie Dupré-Crochet

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Neutrophils are the first cells recruited at the site of infections, where they phagocytose the pathogens. Inside the phagosome, pathogens are killed by proteolytic enzymes that are delivered to the phagosome following granule fusion, and by reactive

Externí odkaz: https://doaj.org/article/3890a16d3a724cca84b11bb38bcd8c66

Rapid viscoelastic changes are a hallmark of early leukocyte activation

Autor: Yolanda R. Carrasco, Claire Hivroz, Pierre-Henri Puech, Yannick Hamon, Sara V. Merino-Cortes, Anaïs Sadoun, Avin Babataheri, Oliver Nüsse, Alexandra Zak, Elodie Hudik, Farah Mustapha, Stéphanie Dogniaux, Hai-Tao He, Abdul I. Barakat, Julien Husson, Sophie Dupré-Crochet

Publikováno v: Biophysical Journal
Biophysical Journal, Biophysical Society, 2021, 120 (9), pp.1692-1704. ⟨10.1016/j.bpj.2021.02.042⟩
Biophys J
Biophysical Journal, 2021, 120 (9), pp.1692-1704. ⟨10.1016/j.bpj.2021.02.042⟩

To accomplish their critical task of removing infected cells and fighting pathogens, leukocytes activate by forming specialized interfaces with other cells. The physics of this key immunological process are poorly understood, but it is important to u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01be502697a4e261b05519b4cc818406
https://doi.org/10.1016/j.bpj.2021.02.042

Contrôle de l’infection des granulocytes neutrophiles par Helicobacter pylori via l’interaction HopQ-CEACAM

Autor: Assmaa Ghali, Oliver Nüsse, Margot Draveny

Publikováno v: médecine/sciences. 37:403-405

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::308428544bb8a4b2c89656f479bc2c61
https://doi.org/10.1051/medsci/2021042

Quantitative live-cell imaging and 3D modeling reveal critical functional features in the cytosolic complex of phagocyte NADPH oxidase

Autor: Cornelia S. Ziegler, Fabienne Merola, Oliver Nüße, Marie Erard, Dominique Durand, Leïla Bouchab, Franck Fieschi, Sophie Dupré-Crochet, Marc Tramier

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2019, 294 (11), pp.3824-3836. ⟨10.1074/jbc.RA118.006864⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (11), pp.3824-3836. ⟨10.1074/jbc.RA118.006864⟩

International audience; Phagocyte NADPH oxidase produces superoxide anions, a precursor of reactive oxygen species (ROS) critical for host responses to microbial infections. However, uncontrolled ROS production contributes to inflammation, making NAD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7416383ae671374c3c4aa4998cbbf71b
https://doi.org/10.1074/jbc.ra118.006864

Consequences of the constitutive NOX2 activity in living cells: cytosol acidification, apoptosis, and localized lipid peroxidation

Autor: Oliver Nüsse, Tania Bizouarn, Laura Baciou, Marie Erard, Sophie Dupré-Crochet, Ariane Deniset-Besseau, Hana Valenta

The phagocyte NADPH oxidase (NOX2) is a key enzyme of the innate immune system generating superoxide anions (O2•−), precursors of reactive oxygen species. The NOX2 protein complex is composed of six subunits: two membrane proteins (gp91phox and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2e279be2b59d604ab57c3c625f432a6
https://doi.org/10.1101/2021.02.23.429648