Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Oliver Medvedik"'
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e261 (2007)
Calorie restriction (CR) robustly extends the lifespan of numerous species. In the yeast Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the activity of sirtuin deacetylases, thereby suppressing the formation of toxic re
Externí odkaz:
https://doaj.org/article/93989e7a876647aabaa90ca605f5e9bd
Autor:
Wendy Choy, Kristine Israelian, J. Joshua Smith, Simon Schenk, Siva Lavu, David P. Carney, Olivier Boss, Philip D. Lambert, Lei Jin, David J. Gagne, David A. Sinclair, Michael R. Jirousek, Andre Iffland, Amy V. Lynch, Jean Bemis, Roger Xie, Robert B. Perni, Pui Yee Ng, Hongying Yang, Jill C. Milne, Jeremy S. Disch, Chi B. Vu, Peter J. Elliott, Jerrold M. Olefsky, Christoph H. Westphal, Heidi Galonek, Oliver Medvedik, Joseph J. Nunes
Publikováno v:
Nature. 450:712-716
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes1,2. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09038e77c147549472bcdfb983cab962
https://doi.org/10.1038/nature06261
https://doi.org/10.1038/nature06261
Publikováno v:
Microbiology and Molecular Biology Reviews. 67:376-399
SUMMARY When it was first proposed that the budding yeast Saccharomyces cerevisiae might serve as a model for human aging in 1959, the suggestion was met with considerable skepticism. Although yeast had proved a valuable model for understanding basic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb409a80ca9021b78b77e768354b1fde
https://doi.org/10.1128/mmbr.67.3.376-399.2003
https://doi.org/10.1128/mmbr.67.3.376-399.2003
Autor:
Jeffrey I. Gordon, Rozalyn M. Anderson, Jason G. Wood, Jill K. Manchester, Haim Y. Cohen, Kevin J. Bitterman, David A. Sinclair, Oliver Medvedik, Stephen S. Lin
Yeast deprived of nutrients exhibit a marked life span extension that requires the activity of the NAD(+)-dependent histone deacetylase, Sir2p. Here we show that increased dosage of NPT1, encoding a nicotinate phosphoribosyltransferase critical for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccc251cc2880f32a073de27307de6bf
https://europepmc.org/articles/PMC3745358/
https://europepmc.org/articles/PMC3745358/
Autor:
Magda Latorre-Esteves, Rozalyn M. Anderson, Ana Rute Neves, Christopher M. Taylor, Konrad T. Howitz, David A. Sinclair, Siva Lavu, Helena Santos, Oliver Medvedik
Publikováno v:
Science. 302:2124-2126
Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae , this effect requires Sir2, a conserved NAD + -dependent deacetylase. We report that CR reduces nuclear NAD + levels in vivo. Moreover, the activity of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec469793a85ee84ed1872b2f75da2fed
https://doi.org/10.1126/science.1088697
https://doi.org/10.1126/science.1088697
Autor:
Alain Viel, Morgan L Paull, Pamela A. Silver, Anugraha M. Raman, Mara C. Inniss, Patrick M. Boyle, Michael A Gedeon, Karmella A. Haynes, Jonathan G dewerd, Oliver Medvedik, Aaron Deardon, Christina M. Agapakis, Jacqueline Y Quinn, Tamara Jane Brenner, Kurt Schellenberg, Julia C. Winn, Mark R. Theilmann, Jagesh V. Shah, George M. Church, Devin R. Burrill, Lu Wang
Publikováno v:
Journal of Biological Engineering, Vol 6, Iss 1, p 8 (2012)
Journal of Biological Engineering
Boyle, Patrick M; Burrill, Devin R; Inniss, Mara C; Agapakis, Christina M; Deardon, Aaron; DeWerd, Jonathan G; et al.(2012). A BioBrick compatible strategy for genetic modification of plants. Journal of Biological Engineering, 6(1), 8. doi: http://dx.doi.org/10.1186/1754-1611-6-8. Retrieved from: http://www.escholarship.org/uc/item/2n01v0mv
Journal of Biological Engineering
Boyle, Patrick M; Burrill, Devin R; Inniss, Mara C; Agapakis, Christina M; Deardon, Aaron; DeWerd, Jonathan G; et al.(2012). A BioBrick compatible strategy for genetic modification of plants. Journal of Biological Engineering, 6(1), 8. doi: http://dx.doi.org/10.1186/1754-1611-6-8. Retrieved from: http://www.escholarship.org/uc/item/2n01v0mv
Background Plant biotechnology can be leveraged to produce food, fuel, medicine, and materials. Standardized methods advocated by the synthetic biology community can accelerate the plant design cycle, ultimately making plant engineering more widely a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7aab765f93622e92b543789e9e15937
http://www.jbioleng.org/content/6/1/8
http://www.jbioleng.org/content/6/1/8
Autor:
Oliver, Medvedik, David A, Sinclair
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 371
The diet known as caloric restriction (CR) has been known for 70 yr to extend the life span of rodents (1). CR can also extend life span in a broad range of other species as well, from unicellular organisms (2,3), to invertebrates (4) and most likely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4a9ad85d93241b34f41af274c1c99dc
https://pubmed.ncbi.nlm.nih.gov/17634577
https://pubmed.ncbi.nlm.nih.gov/17634577
Autor:
Stacy N. Wong, David A. Sinclair, Su Ju Lin, Dudley W. Lamming, Felicia A. Tsang, Magda Latorre-Esteves, Oliver Medvedik, Chen Wang
Publikováno v:
Science (New York, N.Y.). 309(5742)
Calorie restriction (CR) extends the life span of numerous species, from yeast to rodents. Yeast Sir2 is a nicotinamide adenine dinucleotide (NAD + -dependent histone deacetylase that has been proposed to mediate the effects of CR. However, this hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bca36a477a784c8695536999da5c6a0
https://pubmed.ncbi.nlm.nih.gov/16741098
https://pubmed.ncbi.nlm.nih.gov/16741098
Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals. Numerous hypotheses have been proposed to explain this phenomenon, including decreased oxidative damage and altered energy metabolism. In Saccharomyces cerevi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f6f4ec6dd5c6f3259761b333ee5f0a
https://europepmc.org/articles/PMC4802858/
https://europepmc.org/articles/PMC4802858/
Publikováno v:
PLoS Biology
PLoS Biology, Vol 5, Iss 10, p e261 (2007)
PLoS Biology, Vol 5, Iss 10, p e261 (2007)
Calorie restriction (CR) robustly extends the lifespan of numerous species. In the yeast Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the activity of sirtuin deacetylases, thereby suppressing the formation of toxic re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e316d16cb11fa8e227bc791d013cdf2a
https://doi.org/10.1371/journal.pbio.0050261
https://doi.org/10.1371/journal.pbio.0050261