Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Oliver M. T. Pearce"'
Autor:
Joanne Nolan, Oliver M. T. Pearce, Hazel R. C. Screen, Martin M. Knight, Stefaan W. Verbruggen
Publikováno v:
Cancers, Vol 15, Iss 3, p 635 (2023)
Organ-on-chip systems are capable of replicating complex tissue structures and physiological phenomena. The fine control of biochemical and biomechanical cues within these microphysiological systems provides opportunities for cancer researchers to bu
Externí odkaz:
https://doaj.org/article/7ec41ec657b5491cbd0a2f4ae12262ac
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome. One protein in the matrisome that is comm
Externí odkaz:
https://doaj.org/article/dfb20fa42a6c49bba00cd2535b729103
Autor:
Thomas N. Wight, Inkyung Kang, Stephen P. Evanko, Ingrid A. Harten, Mary Y. Chang, Oliver M. T. Pearce, Carys E. Allen, Charles W. Frevert
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a num
Externí odkaz:
https://doaj.org/article/b4f9bdd001fd495a8cc95582e45802de
Autor:
Stefaan W. Verbruggen, Clare L. Thompson, Michael P. Duffy, Sophia Lunetto, Joanne Nolan, Oliver M. T. Pearce, Christopher R. Jacobs, Martin M. Knight
Publikováno v:
Cancers, Vol 13, Iss 12, p 2906 (2021)
Breast and prostate cancers preferentially metastasise to bone tissue, with metastatic lesions forming in the skeletons of most patients. On arriving in bone tissue, disseminated tumour cells enter a mechanical microenvironment that is substantially
Externí odkaz:
https://doaj.org/article/ab4d4dfee0f14351b4f8bf270bc9f406
Autor:
Ana Hennino, Frances R. Balkwill, Marian Novak, Samuel J. Nichols, Pedro R. Cutillas, James D. Brenton, Laura S.M. Lecker, Caterina Trevisan, Daniela Loessner, Ronny Drapkin, Jacqueline McDermott, Vinothini Rajeeve, Owen Heath, Robin M. Delaine-Smith, Oliver M. T. Pearce, Eleni Maniati, Chiara Berlato
Publikováno v:
Cancer Research. 81:5706-5719
The tumor microenvironment evolves during malignant progression, with major changes in nonmalignant cells, cytokine networks, and the extracellular matrix (ECM). In this study, we aimed to understand how the ECM changes during neoplastic transformati
Autor:
Anu Laitala, Sarah McNeilly, Sina Zendehroud, Lene B. Oddershede, Maria Rafaeva, Wilhelm Bloch, Monica Nicolau, Stefanie Sudhop, Stefanie Kiderlen, Janine T. Erler, Alejandro E Mayorca-Guiliani, Frank Suhr, Carina Prein, Lutz Fleischhauer, Kamilla Westarp Zornhagen, Benjamin Furtwängler, Chris D. Madsen, Denise Nikodemus, Tom Van Agtmael, Kyoung-Jae Won, Hyobin Kim, Erwin M. Schoof, Manuel Koch, Eleni Maniati, Hauke Clausen-Schaumann, Oliver M. T. Pearce, Sebastian R. Nielsen, Lena Wullkopf, Roland R. Netz, Bo T. Porse, Raphael Reuten
Publikováno v:
Reuten, R, Zendehroud, S, Nicolau, M, Fleischhauer, L, Laitala, A, Kiderlen, S, Nikodemus, D, Wullkopf, L, Nielsen, S R, McNeilly, S, Prein, C, Rafaeva, M, Schoof, E M, Furtwängler, B, Porse, B T, Kim, H, Won, K J, Sudhop, S, Zornhagen, K W, Suhr, F, Maniati, E, Pearce, O M T, Koch, M, Oddershede, L B, Van Agtmael, T, Madsen, C D, Mayorca-Guiliani, A E, Bloch, W, Netz, R R, Clausen-Schaumann, H & Erler, J T 2021, ' Basement membrane stiffness determines metastases formation ', Nature Materials, vol. 20, pp. 892-903 . https://doi.org/10.1038/s41563-020-00894-0
Nature Materials
Reuten, R, Zendehroud, S, Nicolau, M, Fleischhauer, L, Laitala, A, Kiderlen, S, Nikodemus, D, Wullkopf, L, Nielsen, S R, Mcneilly, S, Prein, C, Rafaeva, M, Schoof, E M, Furtwängler, B, Porse, B T, Kim, H, Won, K J, Sudhop, S, Zornhagen, K W, Suhr, F, Maniati, E, Pearce, O M T, Koch, M, Oddershede, L B, Van Agtmael, T, Madsen, C D, Mayorca-guiliani, A E, Bloch, W, Netz, R R, Clausen-schaumann, H & Erler, J T 2021, ' Basement membrane stiffness determines metastases formation ', Nature Materials, vol. 20, pp. 892–903 . https://doi.org/10.1038/s41563-020-00894-0
Nature Materials
Reuten, R, Zendehroud, S, Nicolau, M, Fleischhauer, L, Laitala, A, Kiderlen, S, Nikodemus, D, Wullkopf, L, Nielsen, S R, Mcneilly, S, Prein, C, Rafaeva, M, Schoof, E M, Furtwängler, B, Porse, B T, Kim, H, Won, K J, Sudhop, S, Zornhagen, K W, Suhr, F, Maniati, E, Pearce, O M T, Koch, M, Oddershede, L B, Van Agtmael, T, Madsen, C D, Mayorca-guiliani, A E, Bloch, W, Netz, R R, Clausen-schaumann, H & Erler, J T 2021, ' Basement membrane stiffness determines metastases formation ', Nature Materials, vol. 20, pp. 892–903 . https://doi.org/10.1038/s41563-020-00894-0
The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. Here we show that BM stiffness is a major determinant of metastases formation in seve
Autor:
Frances R. Balkwill, Huiming Ding, Duanduan Ma, Richard O. Hynes, Oliver M. T. Pearce, Vinothini Rajeeve, Alexandra Naba, Amanda M. Del Rosario, Pedro R. Cutillas
Publikováno v:
J Proteome Res
The extracellular matrix (ECM) is a complex meshwork of insoluble fibrillar proteins and signaling factors interacting together to provide architectural and instructional cues to the surrounding cells. Alterations in ECM organization or composition a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5b73a9117024e3cee92e1a8aa9f57c
Autor:
Marcel P. Trefny, A. Petrone, K. Normington, Jing Wang, L. Peng, J. Broderick, Katharina Glatz, Alfred Zippelius, Erika L. Pearce, N. R. Mantuano, Nicole Kirchhammer, Melissa A. Gray, Abhishek S. Kashyap, Gianni Monaco, David E. Sanin, Oliver M. T. Pearce, Carolyn R. Bertozzi, H. Laeubli, Benjamin Kasenda, Michal A. Stanczak
Immune checkpoint blockade (ICB) has significantly improved the prognosis of cancer patients, but the majority experience limited benefit, evidencing the need for new therapeutic approaches. Upregulation of sialic acid-containing glycans, termed hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4f82d81f465f5112b235d4f929e9103
https://doi.org/10.1101/2021.04.11.439323
https://doi.org/10.1101/2021.04.11.439323
Autor:
Reza Roozitalab, Roanne R. Jones, Oliver M. T. Pearce, Beatrice Malacrida, Sam Nichols, Laura S.M. Lecker, Frances R. Balkwill, Robin M. Delaine-Smith, Eleni Maniati, Martin M. Knight
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102674-(2021)
iScience
iScience
Summary In a multi-level “deconstruction” of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim was to understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077fcbd9aa2de37df67d3c0c5ef5772f
https://doi.org/10.1101/2021.02.01.428374
https://doi.org/10.1101/2021.02.01.428374