Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Oliver M. Sieber"'
Autor:
Laura J. Jenkins, Ian Y. Luk, Fiona Chionh, Tao Tan, Kristen Needham, Jamieson Ayton, Camilla M. Reehorst, Natalia Vukelic, Oliver M. Sieber, Dmitri Mouradov, Peter Gibbs, David S. Williams, Niall C. Tebbutt, Jayesh Desai, Frédéric Hollande, Amardeep S. Dhillon, Erinna F. Lee, Delphine Merino, W. Douglas Fairlie, John M. Mariadason
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-9 (2024)
Abstract Metastatic BRAF V600E colorectal cancer (CRC) carries an extremely poor prognosis and is in urgent need of effective new treatments. While the BRAFV600E inhibitor encorafenib in combination with the EGFR inhibitor cetuximab (Enc+Cet) was rec
Externí odkaz:
https://doaj.org/article/6e4f88d9b616433e88bdbae69ee002cc
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103090- (2024)
Summary: Drug sensitivity testing of patient-derived tumor organoids (PDTOs) is a promising tool for personalizing cancer treatment. Here, we present a protocol for generation of and high-throughput drug testing with PDTOs. We describe detailed steps
Externí odkaz:
https://doaj.org/article/4c6c845d245b4b709890dd2cccce584e
Autor:
Lucy Gately, Katharine Drummond, Mark Rosenthal, Rosemary Harrup, Anthony Dowling, Andrew Gogos, Zarnie Lwin, Ian Collins, David Campbell, Elizabeth Ahern, Claire Phillips, Hui K. Gan, Iwan Bennett, Oliver M. Sieber, Peter Gibbs
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Real-world data (RWD) is increasingly being embraced as an invaluable source of information to address clinical and policy-relevant questions that are unlikely to ever be answered by clinical trials. However, the largely unrealise
Externí odkaz:
https://doaj.org/article/dde2958b8619435fbac30562014e21eb
Autor:
Lars Tögel, Rebecca Nightingale, Rui Wu, Anderly C. Chüeh, Sheren Al-Obaidi, Ian Luk, Mercedes Dávalos-Salas, Fiona Chionh, Carmel Murone, Daniel D. Buchanan, Zac Chatterton, Oliver M. Sieber, Diego Arango, Niall C. Tebbutt, David Williams, Amardeep S. Dhillon, John M. Mariadason
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/2da398f3b9b94697999c98041af917de
Autor:
Yumiko Hirokawa, Jordan Clarke, Michelle Palmieri, Tao Tan, Dmitri Mouradov, Shan Li, Cong Lin, Fuqiang Li, Huijuan Luo, Kui Wu, Maree Faux, Chin Wee Tan, Margaret Lee, Grace Gard, Peter Gibbs, Antony W. Burgess, Oliver M. Sieber
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Given the practical limitations of solid matrix-based protocols in organoid culture, Yumiko Hirokawa et al. assess the ability of low-concentration Matrigel conditions to promote intestinal organoid growth. Their results suggest that a low-viscosity
Externí odkaz:
https://doaj.org/article/006bc56a251a435dbc12018d048e3d9b
Autor:
David K. Lau, Dmitri Mouradov, Wiphawan Wasenang, Ian Y. Luk, Cameron M. Scott, David S. Williams, Yvonne H. Yeung, Temduang Limpaiboon, George F. Iatropoulos, Laura J. Jenkins, Camilla M. Reehorst, Fiona Chionh, Mehrdad Nikfarjam, Daniel Croagh, Amardeep S. Dhillon, Andrew J. Weickhardt, Toshihide Muramatsu, Yoshimasa Saito, Niall C. Tebbutt, Oliver M. Sieber, John M. Mariadason
Publikováno v:
iScience, Vol 21, Iss , Pp 624-637 (2019)
Summary: Biliary tract cancers (BTCs) currently have no approved targeted therapies. Although genomic profiling of primary BTCs has identified multiple potential drug targets, accurate models are needed for their evaluation. Genomic profiling of 22 B
Externí odkaz:
https://doaj.org/article/60855650f6624ff1817442e9b3685ec7
Publikováno v:
Cancers, Vol 14, Iss 15, p 3714 (2022)
Lipids have diverse structures, with multifarious regulatory functions in membrane homeostasis and bioenergetic metabolism, in mediating functional protein–lipid and protein–protein interactions, as in cell signalling and proliferation. An increa
Externí odkaz:
https://doaj.org/article/0f04f33d4879443d9ff8e3e5bdbd47cb
Autor:
Lars Tögel, Rebecca Nightingale, Rui Wu, Anderly C. Chüeh, Sheren Al-Obaidi, Ian Luk, Mercedes Dávalos-Salas, Fiona Chionh, Carmel Murone, Daniel D. Buchanan, Zac Chatterton, Oliver M. Sieber, Diego Arango, Niall C. Tebbutt, David Williams, Amardeep S. Dhillon, John M. Mariadason
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract The ERK signalling pathway regulates key cell fate decisions in the intestinal epithelium and is frequently dysregulated in colorectal cancers (CRCs). Variations in the dynamics of ERK activation can induce different biological outcomes and
Externí odkaz:
https://doaj.org/article/a151607c9cc44b65a4170afe0f9837f7
Autor:
Paul Mittal, Mark R. Condina, Manuela Klingler-Hoffmann, Gurjeet Kaur, Martin K. Oehler, Oliver M. Sieber, Michelle Palmieri, Stefan Kommoss, Sara Brucker, Mark D. McDonnell, Peter Hoffmann
Publikováno v:
Cancers, Vol 13, Iss 21, p 5388 (2021)
Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) can determine the spatial distribution of analytes such as protein distributions in a tissue section according to their mass-to-charge ratio. Here, we explored the clin
Externí odkaz:
https://doaj.org/article/89c98a6a933741a8a47c161c0e4ac318
Autor:
Kendrick Koo, Dmitri Mouradov, Christopher M. Angel, Tim A. Iseli, David Wiesenfeld, Michael J. McCullough, Antony W. Burgess, Oliver M. Sieber
Publikováno v:
Cancers, Vol 13, Iss 5, p 1029 (2021)
Molecular alterations in 176 patients with oral squamous cell carcinomas (OSCC) were evaluated to delineate differences in non-smoking non-drinking (NSND) patients. Somatic mutations and DNA copy number variations (CNVs) in a 68-gene panel and human
Externí odkaz:
https://doaj.org/article/bbbe6be469984641a2ce5d9c21c0efa2