Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Oliver LANGER"'
Autor:
Zacharias Chalampalakis, Markus Ortner, Masar Almuttairi, Martin Bauer, Ernesto Gomez Tamm, Albrecht Ingo Schmidt, Barbara Katharina Geist, Marcus Hacker, Oliver Langer, Roberta Frass-Kriegl, Ivo Rausch
Publikováno v:
EJNMMI Physics, Vol 11, Iss 1, Pp 1-16 (2024)
Abstract Background Accurate pharmacokinetic modelling in PET necessitates measurements of an input function, which ideally is acquired non-invasively from image data. For hepatic pharmacokinetic modelling two input functions need to be considered, t
Externí odkaz:
https://doaj.org/article/89f616357b9347e3b32dd93f85d0c01d
Autor:
Myriam El Biali, Louise Breuil, Matthias Jackwerth, Severin Mairinger, Maria Weber, Michael Wölfl-Duchek, Karsten Bamminger, Ivo Rausch, Lukas Nics, Marcus Hacker, Sebastian Rodrigo, Viviane Bouilleret, Markus Zeitlinger, Ekaterina Pataraia, Nicolas Tournier, Martin Bauer, Oliver Langer
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background P-glycoprotein (P-gp) is an efflux transporter which is abundantly expressed at the blood-brain barrier (BBB) and which has been implicated in the pathophysiology of various brain diseases. The radiolabelled antiemetic drug [11C]m
Externí odkaz:
https://doaj.org/article/8f2fa73b674d4061ac07beba12949ff4
Autor:
Severin Mairinger, Matthias Jackwerth, Ondřej Soukup, Matthias Blaickner, Clemens Decristoforo, Lukas Nics, Jens Pahnke, Marcus Hacker, Markus Zeitlinger, Oliver Langer
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Background 6-Bromo-7-[11C]methylpurine ([11C]BMP) is a radiotracer for positron emission tomography (PET) to measure multidrug resistance-associated protein 1 (MRP1) transport activity in different tissues. Previously reported radiosyntheses
Externí odkaz:
https://doaj.org/article/c48cb573bf5448948f7a081af7f99130
Autor:
Myriam El Biali, Michael Wölfl‐Duchek, Matthias Jackwerth, Severin Mairinger, Maria Weber, Karsten Bamminger, Stefan Poschner, Ivo Rausch, Natalie Schindler, Irene Hernández Lozano, Walter Jäger, Lukas Nics, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Martin Bauer, Oliver Langer
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract St. John's wort (SJW) extract, a herbal medicine with antidepressant effects, is a potent inducer of intestinal and/or hepatic cytochrome P450 (CYP) enzymes and P‐glycoprotein (P‐gp), which can cause clinically relevant drug interactions
Externí odkaz:
https://doaj.org/article/bfdf145153d8476faf6df062d6d1d5d8
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1355-1379 (2022)
Abstract Research conducted over the past 2 decades has enhanced the validity and expanded the applications of microdosing and other phase 0 approaches in drug development. Phase 0 approaches can accelerate drug development timelines and reduce attri
Externí odkaz:
https://doaj.org/article/715be5615ef143948a604c683ce40ef2
Autor:
Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background To better understand the etiology and pathomechanisms of Alzheimer’s disease, several transgenic animal models that overexpress human tau or human amyloid-beta (Aβ) have been developed. In the present study, we generated a nove
Externí odkaz:
https://doaj.org/article/f7befd60ea1646b98674434c48abf123
Autor:
Louise Breuil, Nora Ziani, Sarah Leterrier, Gaëlle Hugon, Fabien Caillé, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sébastien Goutal, Nicolas Tournier
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2650 (2022)
[11C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators which may i
Externí odkaz:
https://doaj.org/article/e65cab58e713472f90382c0f7d93f2af
Autor:
Beatrix Wulkersdorfer, Martin Bauer, Rudolf Karch, Harald Stefanits, Cécile Philippe, Maria Weber, Thomas Czech, Marie-Claude Menet, Xavier Declèves, Johannes A. Hainfellner, Matthias Preusser, Marcus Hacker, Markus Zeitlinger, Markus Müller, Oliver Langer
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters expressed at the blood–brain barrier which effectively restrict the brain distribution of the majority of currently known anticancer
Externí odkaz:
https://doaj.org/article/beb34f2037d5499f8f88efbca9a30902
Autor:
Verena Pichler, Marius Ozenil, Karsten Bamminger, Chrysoula Vraka, Marcus Hacker, Oliver Langer, Wolfgang Wadsak
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-14 (2019)
Abstract Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopram
Externí odkaz:
https://doaj.org/article/7e9ebec01ecf4ef08133fa755eba2953
Autor:
Myriam El Biali, Rudolf Karch, Cécile Philippe, Helmuth Haslacher, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Doreen Schmidl, Oliver Langer, Martin Bauer
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The widely expressed and poly-specific ABC transporters breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1) are co-localized at the blood-brain barrier (BBB) and have shown to limit the brain distribution of several clinically used AB
Externí odkaz:
https://doaj.org/article/b2d49507252745949da4a1005ca8ced1