Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells

Autor: Tim Schader, Oliver Löwe, Christina Reschke, Pedro Malacarne, Fabian Hahner, Niklas Müller, Anna Gajos-Draus, Johannes Backs, Katrin Schröder

Publikováno v: Redox Biology, Vol 36, Iss , Pp 101669- (2020)

NADPH oxidases produce reactive oxygen species that differ in localization, type and concentration. Within the Nox family only Nox4 produces H2O2 which can directly oxidize cysteine residues. With this post-translational modification, activity, stabi

Externí odkaz: https://doaj.org/article/20550cab209f46e1a4628224dcde1426

CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity

Autor: Kim-Kristin Prior, Matthias S. Leisegang, Ivana Josipovic, Oliver Löwe, Ajay M. Shah, Norbert Weissmann, Katrin Schröder, Ralf P. Brandes

Publikováno v: Redox Biology, Vol 9, Iss C, Pp 287-295 (2016)

The NADPH oxidases are important transmembrane proteins producing reactive oxygen species (ROS). Within the Nox family, different modes of activation can be discriminated. Nox1-3 are dependent on different cytosolic subunits, Nox4 seems to be constit

Externí odkaz: https://doaj.org/article/79418e5914ef49f9b7837e9acc35a94c

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis

Autor: Simone Fulda, Lara Kleinesudeik, Stefan Dröse, Katharina Rohde, Katrin Schröder, Juliana Heidler, Stefanie Roesler, Oliver Löwe, Ilka Wittig

Publikováno v: Cell Death & Differentiation. 24:83-97

Necroptosis is a form of programmed cell death that critically depends on RIP3 and MLKL. However, the contribution of mitochondria to necroptosis is still poorly understood. In the present study, we discovered that mitochondrial perturbations play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aedf2cf3e42dac258176f57da71a2a8
https://doi.org/10.1038/cdd.2016.102

CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity

Autor: Matthias S. Leisegang, Norbert Weissmann, Oliver Löwe, Ivana Josipovic, Ralf P. Brandes, Ajay M. Shah, Kim-Kristin Prior, Katrin Schröder

Publikováno v: Prior, K-K, Leisegang, M S, Josipovic, I, Löwe, O, Shah, A M, Weissmann, N, Schröder, K & Brandes, R P 2016, ' CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity ', Redox Biology, vol. 9, pp. 287–295 . https://doi.org/10.1016/j.redox.2016.08.013
Redox Biology
Redox Biology, Vol 9, Iss C, Pp 287-295 (2016)

The NADPH oxidases are important transmembrane proteins producing reactive oxygen species (ROS). Within the Nox family, different modes of activation can be discriminated. Nox1-3 are dependent on different cytosolic subunits, Nox4 seems to be constit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7670eb8e4dc606a7d6d6b3c20008dea2
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/41855

The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype

Autor: Oliver Löwe, Irakli Kopaliani, Arnab Nayak, Katrin Schröder, Ralf P. Brandes, Norbert Weissmann, Beliza Rashid, Franziska Moll, Jeremy Epah, Sabine Harenkamp, Flávia Rezende, Michel Mittelbronn, Christoph Schürmann, Ivana Josipovic, Cornelia Penski, Jeanette Eresch

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 36(8)

Objective— Reactive oxygen species generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases contribute to angiogenesis and vascular repair. NADPH oxidase organizer 1 (NoxO1) is a cytosolic protein facilitating assembly of constitut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30a38cc64aa4f36794eeb5ceea3e4f7
https://pubmed.ncbi.nlm.nih.gov/27283741