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Autor:
Franziska Seifert, Stephan Schilling, Oliver Kupski, Hans-Ulrich Demuth, Lisa-Marie Funk, Viktor Sautner, Franc Meyer, Ulf Diederichsen, Brigitte Worbs, Daniel Ramsbeck, Mirko Buchholz, Kai Tittmann
Publikováno v:
Biochemistry. 59:2585-2591
Amyloidogenic plaques are hallmarks of Alzheimer's disease (AD) and typically consist of high percentages of modified Aβ peptides bearing N-terminally cyclized glutamate residues. The human zinc(II) enzyme glutaminyl cyclase (QC) was shown in vivo t