Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Oliver Kudlacek"'
Autor:
Dino Luethi, Julian Maier, Deborah Rudin, Dániel Szöllősi, Thomas J. F. Angenoorth, Stevan Stankovic, Matthias Schittmayer, Isabella Burger, Jae-Won Yang, Kathrin Jaentsch, Marion Holy, Anand Kant Das, Mario Brameshuber, Gisela Andrea Camacho-Hernandez, Andrea Casiraghi, Amy Hauck Newman, Oliver Kudlacek, Ruth Birner-Gruenberger, Thomas Stockner, Gerhard J. Schütz, Harald H. Sitte
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Phosphatidylinositol 4,5-bisphosphate (PIP2) directly regulates norepinephrine transporter (NET) dimer stabilization at the plasma membrane. Furthermore, PIP2 interaction with NET affects efflux.
Externí odkaz:
https://doaj.org/article/bf06230a2bde4a6abd1164301e9e14ad
Autor:
Basavraj Khanppnavar, Julian Maier, Freja Herborg, Ralph Gradisch, Erika Lazzarin, Dino Luethi, Jae-Won Yang, Chao Qi, Marion Holy, Kathrin Jäntsch, Oliver Kudlacek, Klaus Schicker, Thomas Werge, Ulrik Gether, Thomas Stockner, Volodymyr M. Korkhov, Harald H. Sitte
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The current work reports the structure of the human organic cation transporter 3 (OCT3 / SLC22A3) and provides the structural basis of its inhibition by two specific inhibitors, decynium-22 and corticosterone.
Externí odkaz:
https://doaj.org/article/c390514bb74345508edbb1e105eb04af
Autor:
Kusumika Saha, Jae-Won Yang, Tina Hofmaier, SanthoshKannan Venkatesan, Thomas Steinkellner, Oliver Kudlacek, Sonja Sucic, Michael Freissmuth, Harald H. Sitte
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The eukaryotic endocytic pathway regulates protein levels available at the plasma membrane by recycling them into specific endosomal compartments. ARFGAP1 is a component of the coat protein I (COPI) complex but it also plays a role in promoting adapt
Externí odkaz:
https://doaj.org/article/c91015d8de4844ec947a673c8a661485
Autor:
Andreas Anderluh, Tina Hofmaier, Enrico Klotzsch, Oliver Kudlacek, Thomas Stockner, Harald H. Sitte, Gerhard J. Schütz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The human serotonin transporter (SERT) mediates the uptake of neurotransmitters to terminate neuronal signalling. Here the authors use single-molecule imaging to get insight into the molecular origin of SERT oligomerization and their pre-set stoichio
Externí odkaz:
https://doaj.org/article/bcb1096f3d314ab090f13b2d7e457d58
Autor:
Bulut Hamali, Sandra Pichler, Elisabeth Wischnitzki, Klaus Schicker, Melanie Burger, Marion Holy, Kathrin Jaentsch, Martina Molin, Eva Maria Sehr, Oliver Kudlacek, Michael Freissmuth
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006428 (2018)
The parasitic liver fluke Fasciola hepatica infests mainly ruminants, but it can also cause fasciolosis in people, who ingest the metacercariae encysted on plants. The drug of choice to treat fasciolosis is triclabendazole (TBZ), which has been on th
Externí odkaz:
https://doaj.org/article/86931656fe754726a2a386904dbf13be
Autor:
Thomas Stockner, Therese R Montgomery, Oliver Kudlacek, Rene Weissensteiner, Gerhard F Ecker, Michael Freissmuth, Harald H Sitte
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 2, p e1002909 (2013)
The high-resolution crystal structure of the leucine transporter (LeuT) is frequently used as a template for homology models of the dopamine transporter (DAT). Although similar in structure, DAT differs considerably from LeuT in a number of ways: (i)
Externí odkaz:
https://doaj.org/article/036fd3d1414a46e38bcca194053a7f18
Autor:
Felix P Mayer, Marco Niello, Daniela Cintulova, Spyridon Sideromenos, Julian Maier, Yang Li, Simon Bulling, Oliver Kudlacek, Klaus Schicker, Hideki Iwamoto, Fei Deng, Jinxia Wang, Marion Holy, Rani Katamish, Walter Sandtner, Yulong Li, Daniela Pollak, Randy D Blakely, Marko Mihovilovic, Michael H Baumann, Harald H Sitte
Publikováno v:
Molecular Psychiatry. 28:722-732
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g. social phobias and post-traumatic stress disorder. Recent evidence from preclinical and clinical studies establish
Autor:
Thomas Stockner, Kathrin Jaentsch, Florian Baumgart, Oliver Kudlacek, Anand Kant Das, Harald H. Sitte, Gerhard J. Schütz
Publikováno v:
The Journal of Biological Chemistry
The human dopamine transporter (hDAT) regulates the level of the neurotransmitter dopamine (DA) in the synaptic cleft and recycles DA for storage in the presynaptic vesicular pool. Many neurotransmitter transporters exist as oligomers, but the physio
Autor:
Hsiao Huei Wu, Lynette C. Daws, Harald H. Sitte, Wouter Koek, Isabella Salzer, W. Anthony Owens, Stefan Boehm, Oliver Kudlacek, Piper H. Williams, Mia Apuschkin, Georgianna G. Gould, Peter Chiba, Ulrik Gether, Diethart Schmid, Felix P. Mayer
Publikováno v:
Mayer, F P, Schmid, D, Owens, W A, Gould, G G, Apuschkin, M, Kudlacek, O, Salzer, I, Boehm, S, Chiba, P, Williams, P H, Wu, H-H, Gether, U, Koek, W, Daws, L C & Sitte, H H 2018, ' An unsuspected role for organic cation transporter 3 in the actions of amphetamine ', Neuropsychopharmacology, vol. 43, pp. 2408-2417 . https://doi.org/10.1038/s41386-018-0053-5
Neuropsychopharmacology
Neuropsychopharmacology
Amphetamine abuse is a major public health concern for which there is currently no effective treatment. To develop effective treatments, the mechanisms by which amphetamine produces its abuse-related effects need to be fully understood. It is well kn
Autor:
Oliver Kudlacek, Tina Hofmaier, Anton Luf, Felix P. Mayer, Thomas Stockner, Constanze Nagy, Marion Holy, Michael Freissmuth, Rainer Schmid, Harald H. Sitte
Publikováno v:
J Chem Neuroanat
Cocaine is a naturally occurring and illicitly used psychostimulant drug. Cocaine acts at monoaminergic neurotransmitter transporters to block uptake of the monoamines, dopamine, serotonin and norepinephrine. The resulting increase of monoamines in t