Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Oliver Kraetke"'
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Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain
Autor: Oliver Kraetke, H. Berger, Michael Bienert, Michael Beyermann, K. Fechner, Nadja Heinrich, W Zhang, Jens Furkert
Publikováno v: British Journal of Pharmacology. 151:851-859
Background and purpose: Most of the pharmaceuticals target G-protein-coupled receptors (GPCRs) which can generally activate different signalling events. The aim of this study was to achieve functional selectivity of corticotropin-releasing factor rec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e95acb7f7351dbd3f5fc4655264720d
https://doi.org/10.1038/sj.bjp.0707293
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3
Synthesis of Biologically Active Peptide Nucleic Acid−Peptide Conjugates by Sortase-Mediated Ligation
Autor: Jana Klose, Oliver Kraetke, Yvonne Wolf, Stephan Pritz, Michael Beyermann, Michael Bienert
Publikováno v: The Journal of Organic Chemistry. 72:3909-3912
Sortase A is a transpeptidase that cleaves at a pentapeptide-motif and subsequently transfers the acyl component to a nucleophile containing N-terminal oligoglycines. We investigate the reaction conditions of the sortase-mediated ligation and demonst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb52e12130dc8a52b1ebd8a84eb6b1f7
https://doi.org/10.1021/jo062331l
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6
Ago-Antagonists for G Protein-Coupled Peptide Hormone Receptor by Modifying the Agonist's Signalling Domain
Autor: Wei Zhang, Nadja Heinrich, Jens Furkert, Klaus Fechner, Oliver Kraetke, Michael Bienert, Hartmut Berger, Michael Beyermann
Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9780387736563
Introduction Most of the pharmaceuticals today target at G protein-coupled receptors (GPCRs) [1] that transmit extracellular signals into cells. GPCRs are promiscuous, that means a single receptor can activate different signalling events, presumably
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a58e57b6e1d9a80a1cbe2b745346c255
https://doi.org/10.1007/978-0-387-73657-0_237
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8
Dimerization of corticotropin-releasing factor receptor type 1 is not coupled to ligand binding
Autor: Burkhard Wiesner, Michael Beyermann, Michael Bienert, Oliver Kraetke, Jenny Eichhorst, Jens Furkert
Publikováno v: Journal of receptor and signal transduction research. 25(4-6)
As described previously, receptor dimerization of G protein-coupled receptors may influence signaling, trafficking, and regulation in vivo. Up to now, most studies aiming at the possible role of receptor dimerization in receptor activation and signal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f2bf7d64850efc671b1498a4c6ced9
https://pubmed.ncbi.nlm.nih.gov/16393915
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9
Photoaffinity cross-linking of the corticotropin-releasing factor receptor type 1 with photoreactive urocortin analogues
Autor: Brian Holeran, Michael Beyermann, Emanuel Escher, Oliver Kraetke, Michael Bienert, Hartmut Berger
Publikováno v: Biochemistry. 44(47)
Interaction of natural peptide ligands with class 2 GPCRs, which are targets of biologically important hormones such as glucagon, secretin, and corticotropin-releasing factor (CRF), occurs with a common orientation, in that the ligand C-terminus bind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011e942f5a9ad918adc5f05de06aabc0
https://pubmed.ncbi.nlm.nih.gov/16300406
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