Zobrazeno 1 - 10
of 456
pro vyhledávání: '"Oliver Kepp"'
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Recent findings revealed that neoantigen-specific cytotoxic type 1 regulatory T (TR1) CD4 T cells can subvert cancer immunotherapy by killing type 1 conventional dendritic cells (cDC1s) that present tumor antigens bound to MHC class II. This underlin
Externí odkaz:
https://doaj.org/article/e6ed97161e414306b6d6a69dd4687163
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTRecently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells resp
Externí odkaz:
https://doaj.org/article/9f96b508c7b54f6a817d522f4d0bf0a8
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTRecently, we showed that an autologous DC-based vaccine induces an increase in immunosuppressive PD-L1+ tumor-associated macrophages (TAM) both in the tumor and the tumor draining lymph nodes, thereby blunting the efficacy of therapeutic immu
Externí odkaz:
https://doaj.org/article/f820f10ff2ec44dc81afda3f80a8ab83
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTPreclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects th
Externí odkaz:
https://doaj.org/article/12ebacb501bf4c6090bb4a07b4488d9e
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTDexmedetomidine (DEX) is a highly selective α2-adrenoceptor agonist that is widely used in intensive and anesthetic care for its sedative and anxiolytic properties. DEX has the capacity to alleviate inflammatory pain while limiting immunosup
Externí odkaz:
https://doaj.org/article/af61e579a22d45b2bc5db37f446947a1
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the disti
Externí odkaz:
https://doaj.org/article/04378e7a913f49cfb83c5fd8570ea49b
Autor:
Giulia Cerrato, Carlota Alvarez-Lucena, Allan Sauvat, Yanhua Hu, Sabrina Forveille, Guo Chen, Sylvère Durand, Fanny Aprahamian, Marion Leduc, Omar Motiño, Lisardo Boscá, Qingbo Xu, Oliver Kepp, Guido Kroemer
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-10 (2023)
Abstract Autophagy inducers can prevent cardiovascular aging and age-associated diseases including atherosclerosis. Therefore, we hypothesized that autophagy-inducing compounds that act on atherosclerosis-relevant cells might have a protective role i
Externí odkaz:
https://doaj.org/article/8050014a17f34ad7a86df5bb6a8fb9fb
Autor:
Julia Källberg, Alexandra Harrison, Valerie March, Santa Bērziņa, Ivan Nemazanyy, Oliver Kepp, Guido Kroemer, Sophie Mouillet-Richard, Pierre Laurent-Puig, Valérie Taly, Wenjin Xiao
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-12 (2023)
Abstract The major underlying cause for the high mortality rate in colorectal cancer (CRC) relies on its drug resistance, to which intratumor heterogeneity (ITH) contributes substantially. CRC tumors have been reported to comprise heterogeneous popul
Externí odkaz:
https://doaj.org/article/f3c2f693a1da46e99b45f5f98c739dd7
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTCompelling evidence supports the hypothesis that stress negatively impacts cancer development and prognosis. Irrespective of its physical, biological or psychological source, stress triggers a physiological response that is mediated by the hy
Externí odkaz:
https://doaj.org/article/264b05a2b6ab40cd89e764bdf3608f6f
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTRecent clinical trials have compared the use of different chemotherapeutic regimens as “immune induction therapies” to sensitize cancers to immune checkpoint inhibitors (ICI). Cytotoxic drugs reputed to be inducers of immunogenic cell dea
Externí odkaz:
https://doaj.org/article/87d8bf8b3c7c4c25b6f2c886293f7642