Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Oliver J. Wilkinson"'
Autor:
Martin Wilkinson, Oliver J Wilkinson, Connie Feyerherm, Emma E Fletcher, Dale B Wigley, Mark S Dillingham
Publikováno v:
eLife, Vol 11 (2022)
Following infection of bacterial cells, bacteriophage modulate double-stranded DNA break repair pathways to protect themselves from host immunity systems and prioritise their own recombinases. Here, we present biochemical and structural analysis of t
Externí odkaz:
https://doaj.org/article/deed9afa353444d1ae21096d30bb3ffc
Autor:
Oliver J Wilkinson, Alejandro Martín-González, Haejoo Kang, Sarah J Northall, Dale B Wigley, Fernando Moreno-Herrero, Mark Simon Dillingham
Publikováno v:
eLife, Vol 8 (2019)
CtIP is involved in the resection of broken DNA during the S and G2 phases of the cell cycle for repair by recombination. Acting with the MRN complex, it plays a particularly important role in handling complex DNA end structures by localised nucleoly
Externí odkaz:
https://doaj.org/article/990f52da8a4c4714a3896f10d6bc2499
Autor:
Robert A. Baldock, Matthew Day, Oliver J. Wilkinson, Ross Cloney, Penelope A. Jeggo, Antony W. Oliver, Felicity Z. Watts, Laurence H. Pearl
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2081-2089 (2015)
53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in o
Externí odkaz:
https://doaj.org/article/c06c3687bc4d494f9663a7453ab3cb8b
Autor:
Clara, Aicart-Ramos, Silvia, Hormeno, Oliver J, Wilkinson, Mark S, Dillingham, Fernando, Moreno-Herrero
Publikováno v:
Methods in enzymology. 673
Single molecule biophysics experiments for the study of DNA-protein interactions usually require production of a homogeneous population of long DNA molecules with controlled sequence content and/or internal tertiary structures. Traditionally, Lambda
Autor:
Emily J. Stevens, Daniel J. Morse, Dora Bonini, Seána Duggan, Tarcisio Brignoli, Mario Recker, John A. Lees, Nicholas J. Croucher, Stephen Bentley, Daniel J. Wilson, Sarah G. Earle, Robert Dixon, Angela Nobbs, Howard Jenkinson, Tim van Opijnen, Derek Thibault, Oliver J. Wilkinson, Mark S. Dillingham, Simon Carlile, Rachel M. McLoughlin, Ruth C. Massey
Publikováno v:
Stevens, E J, Morse, D J, Bonini, D, Duggan, S, Brignoli, T, Recker, M, Lees, J A, Croucher, N J, Bentley, S, Wilson, D J, Earle, S G, Dixon, R, Nobbs, A, Jenkinson, H, van Opijnen, T, Thibault, D, Wilkinson, O J, Dillingham, M S, Carlile, S, McLoughlin, R M & Massey, R C 2022, ' Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae ', Microbial Genomics, vol. 8, no. 4, 000784 . https://doi.org/10.1099/mgen.0.000784
Streptococcus pneumoniae is a major human pathogen that can cause severe invasive diseases such as pneumonia, septicaemia and meningitis. Young children are at a particularly high risk, with an estimated 3–4 million cases of severe disease and betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa12bc3cf1377dff58940c9d98862f1
https://research-information.bris.ac.uk/en/publications/30fb23b6-84a5-4583-ab32-70789009fd09
https://research-information.bris.ac.uk/en/publications/30fb23b6-84a5-4583-ab32-70789009fd09
Autor:
Emily J, Stevens, Daniel J, Morse, Dora, Bonini, Seána, Duggan, Tarcisio, Brignoli, Mario, Recker, John A, Lees, Nicholas J, Croucher, Stephen, Bentley, Daniel J, Wilson, Sarah G, Earle, Robert, Dixon, Angela, Nobbs, Howard, Jenkinson, Tim, van Opijnen, Derek, Thibault, Oliver J, Wilkinson, Mark S, Dillingham, Simon, Carlile, Rachel M, McLoughlin, Ruth C, Massey
Publikováno v:
Microbial genomics. 8(4)
Autor:
Pattama Senthong, Geoffrey P. Margison, Oliver J. Wilkinson, Kabir Abdu, Timothy D. Craggs, David M. Williams, Miren K. Aiertza, Andrew C. Povey
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 39:1108-1121
Promutagenic O6-alkylguanine adducts in DNA are repaired in humans by O6-methylguanine-DNA-methyltransferase (MGMT) in an irreversible reaction. Here we describe the synthesis of a phosphoramidite that allows the preparation of oligodeoxyribonucleoti
Autor:
Silvia Hormeno, Oliver J. Wilkinson, Clara Aicart-Ramos, Sahiti Kuppa, Edwin Antony, Mark S. Dillingham, Fernando Moreno-Herrero
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Hormeno, S, Wilkinson, O J, Aicart-Ramos, C, Kuppa, S, Antony, E, Dillingham, M S & Moreno-Herrero, F 2022, ' Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 15, e2112376119 . https://doi.org/10.1073/pnas.2112376119
instname
Hormeno, S, Wilkinson, O J, Aicart-Ramos, C, Kuppa, S, Antony, E, Dillingham, M S & Moreno-Herrero, F 2022, ' Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 15, e2112376119 . https://doi.org/10.1073/pnas.2112376119
Human DNA helicase B (HELB) is a poorly characterized helicase suggested to play both positive and negative regulatory roles in DNA replication and recombination. In this work, we used bulk and single-molecule approaches to characterize the biochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00eb3c5b3374c5497a5bb49fe18495e
http://hdl.handle.net/10261/266694
http://hdl.handle.net/10261/266694
Autor:
Hormeno S, Mark S. Dillingham, Sahiti Kuppa, Oliver J Wilkinson, Clara Aicart-Ramos, Fernando Moreno-Herrero, Edwin Antony
Publikováno v:
bioRxiv
Human HELB is a poorly-characterised helicase suggested to play both positive and negative regulatory roles in DNA replication and recombination. In this work, we used bulk and single molecule approaches to characterise the biochemical activities of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4e5f9e7164b6c3ebbbdf7ed33d3b5c
https://doi.org/10.1101/2021.05.27.445972
https://doi.org/10.1101/2021.05.27.445972