Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Oliver J Pickles"'
Autor:
Kasun Wanigasooriya, Joao D. Barros-Silva, Louise Tee, Mohammed E. El-asrag, Agata Stodolna, Oliver J. Pickles, Joanne Stockton, Claire Bryer, Rachel Hoare, Celina M. Whalley, Robert Tyler, Toritseju Sillo, Christopher Yau, Tariq Ismail, Andrew D. Beggs
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectivesPartial or total resistance to preoperative chemoradiotherapy occurs in more than half of locally advanced rectal cancer patients. Several novel or repurposed drugs have been trialled to improve cancer cell sensitivity to radiotherapy, with
Externí odkaz:
https://doaj.org/article/a68422d51da247698891b279834c4704
Autor:
Oliver J. Pickles, Kasun Wanigasooriya, Anetta Ptasinska, Akshay J. Patel, Helen L. Robbins, Claire Bryer, Celina M. Whalley, Louise Tee, Neeraj Lal, Maria Pinna, Nahla Elzefzafy, Phillipe Taniere, Andrew D. Beggs, Gary W. Middleton
Publikováno v:
Cancer Research. 83:2989-2989
Introduction: Tumor specific MHC class II (tsMHC-II) expression impacts tumor microenvironmental immunity. tsMHC-II positive cancer cells act as surrogate antigen presenting cells and targets for CD4+ T cell-mediated lysis. In colorectal cancer (CRC)
Autor:
Celina Whalley, Charlotte Poxon, Gabriella L. Morley, Kasun Wanigasooriya, Lyndsey A Dunbar, Mark T. Drayson, Dee E McLoughlin, Saly Al-Taei, Mark I. Garvey, Beena Emmanuel, Golaleh McGinnell, Sian E Jossi, Megan Richter, Andrew D Beggs, Marisol Perez-Toledo, Joel D. Allen, Adam F. Cunningham, Eloise M Walker, Agnieszka E. Zielinska, Joanna Gray, Max Crispin, Joanna O'Neill, Erin L. Aldera, Adrian M Shields, David C. Wraith, Andrew Bosworth, Oliver J Pickles, Sian E Faustini, Claire Backhouse, Alex G. Richter, Daniel Ebanks, I. Michael Kidd, Danai Papakonstantinou, Yasunori Watanabe
Publikováno v:
Thorax
ObjectiveTo determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers.DesignA cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020.SettingUniversity Hospita
Publikováno v:
Oncotarget
The BEACON CRC trial demonstrated a survival advantage over chemotherapy for a combination of targeted agents comprising the potent BRAF inhibitor encorafenib together with cetuximab and binimetinib. Resistance to BRAF inhibition in CRC arises in par
Autor:
Celina Whalley, Andrew D Beggs, Oliver J Pickles, Rachel Hoare, Kasun Wanigasooriya, Tortieju Sillo, Mohammed E. El-Asrag, Robert Tyler, Louise Tee, Tariq Ismail, João D. Barros-Silva, Agata Stodolna, Joanne D. Stockton, Christopher Yau, Claire Bryer
Partial or total resistance to preoperative chemoradiotherapy occurs in more than half of locally advanced rectal cancer patients. Several novel or repurposed drugs have been trialled to improve cancer cell sensitivity to radiotherapy, with limited s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f360ef6663cfb090a839265b85f193
https://doi.org/10.1101/2021.08.31.458326
https://doi.org/10.1101/2021.08.31.458326
Autor:
Alvin J.X. Lee, Thomas Starkey, Vinton Cheng, Gary Middleton, D.J. Hughes, Lennard Y W Lee, Karin Purshouse, Luke Freeman-Mills, Oliver J Pickles, Anna Olsson-Brown
Publikováno v:
British Journal of Cancer
SummaryThe rapid emergence of COVID-19 has sent shockwaves through healthcare systems globally, with cancer patients at increased risk. The interplay of the virus and host immune system has been implicated in the development of ARDS. Immunotherapy ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b6a3596f53f49a41a079ead932d07a
https://eprints.whiterose.ac.uk/162432/3/BJC_240423.pdf
https://eprints.whiterose.ac.uk/162432/3/BJC_240423.pdf
Autor:
Andrew Ellis, Alex G. Richter, Oliver J Pickles, Eloise M Walker, Gabriella L. Morley, Craig Webster, Kasun Wanigasooriya, Andrew D Beggs, Celina Whalley, Andrew Bosworth, Dee E McLoughlin, Danai Papakonstantinou, Charlie Poxon, Agnieszka E. Zielinska, Tim Plant, I. Michael Kidd, Erin L. Aldera
Publikováno v:
Journal of Clinical Virology
Background In January 2020 reports of unidentified severe respiratory illness were described in Wuhan, China. A rapid expansion in cases affecting most countries around the globe led to major changes in the way people live their daily lives. In the U
Autor:
Brian S. White, Andrew D Beggs, Michael Mason, Gary Middleton, Philippe Taniere, Benjamin E. Willcox, Oliver J Pickles, Neeraj Lal, Ghaleb Goussous, Justin Guinney
Publikováno v:
Clinical Cancer Research. 24:224-233
Purpose: KRAS mutation is a common canonical mutation in colorectal cancer, found at differing frequencies in all consensus molecular subtypes (CMS). The independent immunobiological impacts of RAS mutation and CMS are unknown. Thus, we explored the
Autor:
S. Patel, Celina Whalley, Oliver J Pickles, Kasun Wanigasooriya, J.D. Barros Silva, H. Bermingham, Agata Stodolna, Claire Bryer, R. Hoare, Andrew D Beggs
Publikováno v:
Annals of Oncology. 30:vii26
Background More than 70% of patients diagnosed with colorectal cancer with liver metastasis have unresectable disease, so the available treatment is systemic chemotherapy that has limited efficacy and causes harmful side-effects. Thus novel and more
Autor:
Jayne A. Franklyn, Oliver J. Brand, Paul R. Newby, Matthew J. Simmonds, David M. Evans, Simon H. S. Pearce, Samaresh Mazumdar, Oliver J Pickles, Jaqueline D Carr-Smith, Stephen C. L. Gough
Publikováno v:
European Journal of Human Genetics. 18:1021-1026
A recent association scan using a genome-wide set of nonsynonymous coding single-nucleotide polymorphisms (nsSNPs) conducted in four diseases including Graves' disease (GD), identified nine novel possible regions of association with GD. We used a cas