Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Oliver J, McElvaney"'
Autor:
Jennifer Clarke, Pierce Geoghegan, Natalie McEvoy, Maria Boylan, Orna Ní Choileáin, Martin Mulligan, Grace Hogan, Aoife Keogh, Oliver J. McElvaney, Oisín F. McElvaney, John Bourke, Bairbre McNicholas, John G. Laffey, Noel G. McElvaney, Gerard F. Curley
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Objective We aimed to characterize the effects of prone positioning on respiratory mechanics and oxygenation in invasively ventilated patients with SARS-CoV-2 ARDS. Results This was a prospective cohort study in the Intensive Care Unit (ICU)
Externí odkaz:
https://doaj.org/article/94a79657b32f4c889115ec3f9fe0ca2d
Autor:
Oisin F. McElvaney, Takanori Asakura, Suzanne L. Meinig, Jose L. Torres-Castillo, Robert S. Hagan, Claudie Gabillard, Mark P. Murphy, Leigh B. Thorne, Alain Borczuk, Emer P. Reeves, Ross E. Zumwalt, Yu Mikami, Tomas P. Carroll, Kenichi Okuda, Grace Hogan, Oliver J. McElvaney, Jennifer Clarke, Natalie L. McEvoy, Patrick W. Mallon, Cormac McCarthy, Ger Curley, Matthew C. Wolfgang, Richard C. Boucher, Noel G. McElvaney
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103894- (2022)
Summary: Background: Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease. We investigated the protease-anti-protease balance in the circulation and
Externí odkaz:
https://doaj.org/article/8689f1b6c49645dc94c1c385411f7c38
Autor:
Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Caspase 11 activation involves transcriptional upregulation and proteolytic cleavage. Here the authors show that prostaglandin E2 prevents caspase-11-mediated pyroptosis, blocking caspase-11 mRNA and protein upregulation in macrophages and in vivo, a
Externí odkaz:
https://doaj.org/article/f9f58905287b4fe39d8a26ba82a9f274
Autor:
Oisín F. McElvaney, Daniel D. Fraughen, Oliver J. McElvaney, Tomás P. Carroll, Noel G. McElvaney
Publikováno v:
Expert Review of Respiratory Medicine. 17:191-202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5c31d0aa91579cf4328247c3daf9f0d
https://doi.org/10.1080/17476348.2023.2174973
https://doi.org/10.1080/17476348.2023.2174973
Autor:
Francesco Palmas, Jennifer Clarke, Romain A Colas, Esteban A Gomez, Aoife Keogh, Maria Boylan, Natalie McEvoy, Oliver J McElvaney, Oisin McElvaney, Razi Alalqam, Noel G McElvaney, Gerard F Curley, Jesmond Dalli
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256226 (2021)
Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct cause of over 2.2 million deaths worldwide. A timely coordinated host-immune response represents the leading dr
Externí odkaz:
https://doaj.org/article/7f9563a15fbe4d7892bc459854e42685
Autor:
Oliver J McElvaney, Brian D Hobbs, Dandi Qiao, Oisín F McElvaney, Matthew Moll, Natalie L McEvoy, Jennifer Clarke, Eoin O'Connor, Sean Walsh, Michael H Cho, Gerard F Curley, Noel G McElvaney
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103116- (2020)
Externí odkaz:
https://doaj.org/article/411446b76dc54c31854f2e537c22f35c
Autor:
Elaine Hayes, Mark P. Murphy, Kerstin Pohl, Niall Browne, Karen McQuillan, Le Er Saw, Clare Foley, Fatma Gargoum, Oliver J. McElvaney, Padraig Hawkins, Cedric Gunaratnam, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Studies have endeavored to understand the cause for impaired antimicrobial killing by neutrophils of people with cystic fibrosis (PWCF). The aim of this study was to focus on the bacterial phagosome. Possible alterations in degranulation of cytoplasm
Externí odkaz:
https://doaj.org/article/04ebfc8332b446b99afb537fda32bd8c
Publikováno v:
Seminars in Respiratory and Critical Care Medicine. 44:225-241
With the improving survival of cystic fibrosis (CF) patients and the advent of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) therapy, the clinical spectrum of this complex multisystem disease continues to evolve. One of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23266a2b9311e46976fd2eaaaeea41e6
https://doi.org/10.1055/s-0042-1760250
https://doi.org/10.1055/s-0042-1760250
Autor:
Oliver J McElvaney, Brian D Hobbs, Dandi Qiao, Oisín F McElvaney, Matthew Moll, Natalie L McEvoy, Jennifer Clarke, Eoin O'Connor, Seán Walsh, Michael H Cho, Gerard F Curley, Noel G McElvaney
Publikováno v:
EBioMedicine, Vol 61, Iss , Pp 103026- (2020)
Background: Prognostic tools are required to guide clinical decision-making in COVID-19. Methods: We studied the relationship between the ratio of interleukin (IL)-6 to IL-10 and clinical outcome in 80 patients hospitalized for COVID-19, and created
Externí odkaz:
https://doaj.org/article/1d38fb306d08484598bb8a9fed4d0a41
Autor:
Karen McQuillan, Fatma Gargoum, Mark P. Murphy, Oliver J. McElvaney, Noel G. McElvaney, Emer P. Reeves
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
In people with cystic fibrosis (PWCF), inflammation with concurrent infection occurs from a young age and significantly influences lung disease progression. Studies indicate that neutrophils are important effector cells in the pathogenesis of CF and
Externí odkaz:
https://doaj.org/article/5d94c2d258e641ff9bfca8b433698f42