Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Oliver Harschnitz"'
Autor:
Renata Vieira de Sá, Emma Sudria-Lopez, Marta Cañizares Luna, Oliver Harschnitz, Dianne M. A. van den Heuvel, Sandra Kling, Danielle Vonk, Henk-Jan Westeneng, Henk Karst, Lauri Bloemenkamp, Suzy Varderidou-Minasian, Domino K. Schlegel, Mayte Mars, Mark H. Broekhoven, Nicky C. H. van Kronenburg, Youri Adolfs, Vamshidhar R. Vangoor, Rianne de Jongh, Tijana Ljubikj, Lianne Peeters, Sabine Seeler, Enric Mocholi, Onur Basak, David Gordon, Fabrizio Giuliani, Tessa Verhoeff, Giel Korsten, Teresa Calafat Pla, Morten T. Venø, Jørgen Kjems, Kevin Talbot, Michael A. van Es, Jan H. Veldink, Leonard H. van den Berg, Pavol Zelina, R. Jeroen Pasterkamp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Intermediate-length repeat expansions in ATAXIN-2 (ATXN2) are the strongest genetic risk factor for amyotrophic lateral sclerosis (ALS). At the molecular level, ATXN2 intermediate expansions enhance TDP-43 toxicity and pathology. However, wh
Externí odkaz:
https://doaj.org/article/f542924285bc411ab2ef82b8bba3d188
Autor:
Suzy Varderidou-Minasian, Bert M. Verheijen, Oliver Harschnitz, Sandra Kling, Henk Karst, W. Ludo van der Pol, R. Jeroen Pasterkamp, Maarten Altelaar
Publikováno v:
ACS Omega, Vol 6, Iss 51, Pp 35375-35388 (2021)
Externí odkaz:
https://doaj.org/article/e82a0a9c2a524d3fa27fb3e05b82551b
Autor:
Rene’ D. Largo, Maximilian G. Burger, Oliver Harschnitz, Conny F. Waschkies, Andrea Grosso, Celeste Scotti, Alexandre Kaempfen, Sinan Gueven, Gernot Jundt, Arnaud Scherberich, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The first choice for reconstruction of clinical-size bone defects consists of autologous bone flaps, which often lack the required mechanical strength and cause significant donor-site morbidity. We have previously developed biological substitutes in
Externí odkaz:
https://doaj.org/article/95eec5473b7c493fb12aca288fa77896
Autor:
Paul R. Ormel, Renata Vieira de Sá, Emma J. van Bodegraven, Henk Karst, Oliver Harschnitz, Marjolein A. M. Sneeboer, Lill Eva Johansen, Roland E. van Dijk, Nicky Scheefhals, Amber Berdenis van Berlekom, Eduardo Ribes Martínez, Sandra Kling, Harold D. MacGillavry, Leonard H. van den Berg, René S. Kahn, Elly M. Hol, Lot D. de Witte, R. Jeroen Pasterkamp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human mic
Externí odkaz:
https://doaj.org/article/0f43c1e80fff44ada197169a4b75a7dc
Autor:
Wouter van Rheenen, Frank P Diekstra, Oliver Harschnitz, Henk-Jan Westeneng, Kristel R van Eijk, Christiaan G J Saris, Ewout J N Groen, Michael A van Es, Hylke M Blauw, Paul W J van Vught, Jan H Veldink, Leonard H van den Berg
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198874 (2018)
The biological pathways involved in amyotrophic lateral sclerosis (ALS) remain elusive and diagnostic decision-making can be challenging. Gene expression studies are valuable in overcoming such challenges since they can shed light on differentially r
Externí odkaz:
https://doaj.org/article/b3e99309fc2a4f96ac6fbd36980e6fab
Autor:
Renske I Wadman, Marloes Stam, Marc D Jansen, Yana van der Weegen, Camiel A Wijngaarde, Oliver Harschnitz, Peter Sodaar, Kees P J Braun, Dennis Dooijes, Henny H Lemmink, Leonard H van den Berg, W Ludo van der Pol
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167087 (2016)
Clinical trials to test safety and efficacy of drugs for patients with spinal muscular atrophy (SMA) are currently underway. Biomarkers that document treatment-induced effects are needed because disease progression in childhood forms of SMA is slow a
Externí odkaz:
https://doaj.org/article/e99f54abe7b64ae79f3fd84102bb4fb4
Autor:
Zhiyong Liu, Eduardo J. Garcia Reino, Oliver Harschnitz, Hongyan Guo, Yi-Hao Chan, Noopur V. Khobrekar, Mary L. Hasek, Kerry Dobbs, Darawan Rinchai, Marie Materna, Daniela Matuozzo, Danyel Lee, Paul Bastard, Jie Chen, Yoon Seung Lee, Seong K. Kim, Shuxiang Zhao, Param Amin, Lazaro Lorenzo, Yoann Seeleuthner, Remi Chevalier, Laure Mazzola, Claire Gay, Jean-Louis Stephan, Baptiste Milisavljevic, Soraya Boucherit, Flore Rozenberg, Rebeca Perez de Diego, Richard D. Dix, Nico Marr, Vivien Béziat, Aurelie Cobat, Mélodie Aubart, Laurent Abel, Stephane Chabrier, Gregory A. Smith, Luigi D. Notarangelo, Edward S. Mocarski, Lorenz Studer, Jean-Laurent Casanova, Shen-Ying Zhang
Publikováno v:
Science Immunology. 8
Inborn errors of TLR3-dependent type I IFN immunity in cortical neurons underlie forebrain herpes simplex virus-1 (HSV-1) encephalitis (HSE) due to uncontrolled viral growth and subsequent cell death. We report an otherwise healthy patient with HSE w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::276f4f9077671f7d3a35001fd8415b45
https://doi.org/10.1126/sciimmunol.ade2860
https://doi.org/10.1126/sciimmunol.ade2860
Autor:
Lisa Bauer, Brigitta M. Laksono, Femke M.S. de Vrij, Steven A. Kushner, Oliver Harschnitz, Debby van Riel
Publikováno v:
Trends in Neurosciences. 45:358-368
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e31053fe16599335e86a79ab156fbe
https://doi.org/10.1016/j.tins.2022.02.006
https://doi.org/10.1016/j.tins.2022.02.006
Publikováno v:
Curr Opin Immunol
Viral encephalitis is a major neglected medical problem. Host defense mechanisms against viral infection of the central nervous system (CNS) have long remained unclear. The few previous studies of CNS-specific immunity to viruses in mice in vivo and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac34981994875a17247d6c0eb2ef6d3
https://doi.org/10.1016/j.coi.2021.07.004
https://doi.org/10.1016/j.coi.2021.07.004
Autor:
Oliver Harschnitz, Eleonora Conti
Publikováno v:
Development. 149
Placodes are embryonic structures originating from the rostral ectoderm that give rise to highly diverse organs and tissues, comprising the anterior pituitary gland, paired sense organs and cranial sensory ganglia. Their development, including the un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0ba98db24999ffc4818698d95af2fb
https://doi.org/10.1242/dev.200831
https://doi.org/10.1242/dev.200831