Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Oliver H Krämer"'
Autor:
Martina Korfei, Daniel Stelmaszek, BreAnne MacKenzie, Sylwia Skwarna, Shashipavan Chillappagari, Anna C Bach, Clemens Ruppert, Shigeki Saito, Poornima Mahavadi, Walter Klepetko, Ludger Fink, Werner Seeger, Joseph A Lasky, Soni S Pullamsetti, Oliver H Krämer, Andreas Guenther
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207915 (2018)
BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with a poor prognosis. Pirfenidone is the first antifibrotic agent to be approved for IPF-treatment as it is able to slow down disease progression. However, there is no cura
Externí odkaz:
https://doaj.org/article/9580a869135f483091e8096077b94aed
Autor:
Anita G. Kansy, Ramy Ashry, Al‐Hassan M. Mustafa, Abdallah M. Alfayomy, Markus P. Radsak, Yanira Zeyn, Matthias Bros, Wolfgang Sippl, Oliver H. Krämer
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1958-1965 (2024)
Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon DNA replication stress is the checkpoint kinase ataxia‐telangiectasia‐and‐RAD3‐rela
Externí odkaz:
https://doaj.org/article/3c603aa7f4ed49c783038eaa1696cb4c
Autor:
Marten A. Fischer, Al-Hassan M. Mustafa, Kristin Hausmann, Ramy Ashry, Anita G. Kansy, Magdalena C. Liebl, Christina Brachetti, Andrea Piée-Staffa, Matthes Zessin, Hany S. Ibrahim, Thomas G. Hofmann, Mike Schutkowski, Wolfgang Sippl, Oliver H. Krämer
Publikováno v:
Journal of Advanced Research, Vol 60, Iss , Pp 201-214 (2024)
Introduction: Posttranslational modification of proteins by reversible acetylation regulates key biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are frequently dysregulated in tumors. This has spurred the develop
Externí odkaz:
https://doaj.org/article/0bdd50c9fd09429e928b1f2b75be1138
Autor:
Alexandra Nguyen, Al-Hassan M. Mustafa, Alessa K. Leydecker, Melisa Halilovic, Janine Murr, Falk Butter, Oliver H. Krämer
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract As a major source of cellular serine and threonine phosphatase activity, protein phosphatase-2A (PP2A) modulates signaling pathways in health and disease. PP2A complexes consist of catalytic, scaffolding, and B-type subunits. Seventeen PP2A
Externí odkaz:
https://doaj.org/article/9e6174433b8147c5a564a52252e4791f
Autor:
Carolin Bier, Rouven Hecht, Lena Kunst, Sabine Scheiding, Désirée Wünsch, Dorothée Goesswein, Günter Schneider, Oliver H Krämer, Shirley K Knauer, Roland H Stauber
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e34142 (2012)
BACKGROUND: The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes activated by Taspase1 hydrolysis and is considered to promote oncogenic trans
Externí odkaz:
https://doaj.org/article/052fdaa489ba4ab18fcf24020b680de9
Autor:
Diaaeldin I. Abdallah, Elvin D. de Araujo, Naman H. Patel, Lina S. Hasan, Richard Moriggl, Oliver H. Krämer, Patrick T. Gunning
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 757-779 (2023)
Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gene expression at the DNA level. This tight regulation
Externí odkaz:
https://doaj.org/article/34581887751b4ed39c2cde49dcc5b039
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/6478303c9d7a4ec5aa2f0519c8e40390
Autor:
Christian Marx, Jürgen Sonnemann, Oliver D. K. Maddocks, Lisa Marx-Blümel, Mandy Beyer, Doerte Hoelzer, René Thierbach, Claudia Maletzki, Michael Linnebacher, Thorsten Heinzel, Oliver H. Krämer
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Background Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms that modulate cell met
Externí odkaz:
https://doaj.org/article/b54be1c1c57b4247a2dde92cec4134b4
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/ad8d8cb6aaaf41e68da72e07e4c53255
Autor:
Christian Schneeweis, Zonera Hassan, Katja Ascherl, Matthias Wirth, Stella Koutsouli, Felix Orben, Lukas Krauß, Carolin Schneider, Rupert Öllinger, Oliver H. Krämer, Roland Rad, Maximilian Reichert, Maria S. Robles, Dieter Saur, Günter Schneider
Publikováno v:
Cancer Communications, Vol 42, Iss 4, Pp 360-364 (2022)
Externí odkaz:
https://doaj.org/article/e1fb4121e0174834a41aa53409ac05ce