Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Oliver Fleetwood"'
Publikováno v:
eLife, Vol 10 (2021)
Ligand binding stabilizes different G protein-coupled receptor states via a complex allosteric process that is not completely understood. Here, we have derived free energy landscapes describing activation of the β2 adrenergic receptor bound to ligan
Externí odkaz:
https://doaj.org/article/7376f2d61a57476ba3098836f6f979af
Autor:
Nicolas Panel, Duc Duy Vo, Nour Aldin Kahlous, Harald Hübner, Stephanie Tiedt, Pierre Matricon, Jody Pacalon, Oliver Fleetwood, Stefanie Kampen, Andreas Luttens, Lucie Delemotte, Jan Kihlberg, Peter Gmeiner, Jens Carlsson
Publikováno v:
Angewandte Chemie International Edition. 62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38aa8d33730254f1674b87c4ee3ed759
https://doi.org/10.1002/anie.202218959
https://doi.org/10.1002/anie.202218959
Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor
Publikováno v:
Journal of Chemical Information and Modeling
Nanobody binding stabilizes G-protein-coupled receptors (GPCR) in a fully active state and modulates their affinity for bound ligands. However, the atomic-level basis for this allosteric regulation remains elusive. Here, we investigate the conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e84cbaf1430348b2f3948b911dd46c
http://europepmc.org/articles/PMC8715506
http://europepmc.org/articles/PMC8715506
Publikováno v:
Biochemistry
Agonist binding to G protein-coupled receptors (GPCRs) leads to conformational changes in the transmembrane region that activate cytosolic signaling pathways. Although high-resolution structures of different receptor states are available, atomistic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0253c790048a53751ff5169410f1aad
https://doi.org/10.1021/acs.biochem.9b00842
https://doi.org/10.1021/acs.biochem.9b00842
G protein-coupled receptors (GPCRs) shift between inactive states and active signaling states, to which intracellular binding partners can bind. Extracellular binding of ligands stabilizes different receptor states and modulates the intracellular res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43a92b4da7b4e2f0965749e1e9cb5538
https://doi.org/10.1101/2020.07.06.186601
https://doi.org/10.1101/2020.07.06.186601
Many membrane proteins are modulated by external stimuli, such as small molecule binding or change in pH, transmembrane voltage or temperature. This modulation typically occurs at sites that are structurally distant from the functional site. Revealin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00ccdc378e4d04c56137ddcaf2213ac
Publikováno v:
Biophysical Journal. 121:285a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99110487dc86b62db6782a039933eb05
https://doi.org/10.1016/j.bpj.2021.11.1324
https://doi.org/10.1016/j.bpj.2021.11.1324
Autor:
Lucie Delemotte, Oliver Fleetwood
Publikováno v:
Biophysical Journal. 120:94a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8cf04591b06860c9d9b9fe0ebbd2c14
https://doi.org/10.1016/j.bpj.2020.11.778
https://doi.org/10.1016/j.bpj.2020.11.778
Autor:
Berry, Oliver Fleetwood
Species conservation relies on determining the mechanisms that cause endangerment. This thesis documents the conservation ecology and phylogeography of an endangered lizard, Oligosoma grande, from southern New Zealand, and tests hypotheses that may e
Externí odkaz:
http://hdl.handle.net/10179/1747