Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Oliver Fleck"'
1
Akademický článek
Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNALys UUU modifications
Autor: Desirée Villahermosa, Oliver Fleck
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Efficient protein synthesis in eukaryotes requires diphthamide modification of translation elongation factor eEF2 and wobble uridine modifications of tRNAs. In higher eukaryotes, these processes are important for preventing neurological and
Externí odkaz: https://doaj.org/article/11def878f1554a639386e93c7213cc02
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2
Akademický článek
Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats
Autor: Desirée Villahermosa, Olaf Christensen, Karen Knapp, Oliver Fleck
Publikováno v: G3: Genes, Genomes, Genetics, Vol 7, Iss 5, Pp 1463-1473 (2017)
Defective mismatch repair (MMR) in humans is associated with colon cancer and instability of microsatellites, that is, DNA sequences with one or several nucleotides repeated. Key factors of eukaryotic MMR are the heterodimers MutSα (Msh2-Msh6), whic
Externí odkaz: https://doaj.org/article/557115380be44fb4a79cd87c3e653332
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3
Role for Nucleotide Excision Repair Gene Variants in Oxaliplatin-Induced Peripheral Neuropathy
Autor: Oliver Fleck, Jeremy Peter Cheadle, Rebecca Harris, Michael J. Wagner, Howard L. McLeod, Richard Adams, Tim Maughan, Richard Kaplan, Michelle Coffey, David Fisher, Hannah West, James Colley
Publikováno v: JCO precision oncology. 2
Purpose Oxaliplatin forms part of routine treatment of advanced colorectal cancer; however, it often causes severe peripheral neuropathy, resulting in treatment discontinuation. We sought to determine the molecular and cellular mechanism underlying t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9195367898bf25117221eb49ba005a
https://pubmed.ncbi.nlm.nih.gov/35135151
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4
Schizosaccharomyces pombeMutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats
Autor: Karen Knapp, Oliver Fleck, Desirée Villahermosa, Olaf Christensen
Publikováno v: G3: Genes, Genomes, Genetics, Vol 7, Iss 5, Pp 1463-1473 (2017)
G3: Genes|Genomes|Genetics
Defective mismatch repair (MMR) in humans is associated with colon cancer and instability of microsatellites, that is, DNA sequences with one or several nucleotides repeated. Key factors of eukaryotic MMR are the heterodimers MutSα (Msh2-Msh6), whic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9ec602ea60ad6ebf0c9d501905b49e
https://doi.org/10.1534/g3.117.040816
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5
A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents
Autor: Desirée Villahermosa, Karen Knapp, Oliver Fleck
Publikováno v: Current Genetics
Dph3 is involved in diphthamide modification of the eukaryotic translation elongation factor eEF2 and in Elongator-mediated modifications of tRNAs, where a 5-methoxycarbonyl-methyl moiety is added to wobble uridines. Lack of such modifications affect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bbc7b3e7bc11ccf2179be5f44f4e76
http://sro.sussex.ac.uk/id/eprint/73369/1/Villahermosa_et_al-2017c-Current_Genetics.pdf
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6
Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication
Autor: Marie-Fabrice Uwamahoro Gasasira, Antony M. Carr, Oliver Fleck, Edgar Hartsuiker, Christian Holmberg, Olaf Nielsen, Ulrik Fahnøe, Katrine Vyff Løvschal, Birthe B. Kragelund, Irina N. Marinova
Publikováno v: Genes; Volume 8; Issue 5; Pages: 128
Fleck, O, Fahnøe, U, Løvschal, K V, Gasasira, M-F U, Marinova, I N, Kragelund, B B, Carr, A M, Hartsuiker, E, Holmberg, C & Nielsen, O 2017, ' Deoxynucleoside salvage in fission yeast allows rescue of ribonucleotide reductase deficiency but not Spd1-mediated inhibition of replication ', Genes, vol. 8, no. 5, 128 . https://doi.org/10.3390/genes8050128
Genes, Vol 8, Iss 5, p 128 (2017)
Genes
In fission yeast, the small, intrinsically disordered protein S-phase delaying protein 1 (Spd1) blocks DNA replication and causes checkpoint activation at least in part, by inhibiting the enzyme ribonucleotide reductase, which is responsible for the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5598060f700d1aa97dee454a8edc4e
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9
Ddb1 controls genome stability and meiosis in fission yeast
Autor: Heidi A. Hansen, Antony M. Carr, Cong Liu, Oliver Fleck, Olaf Nielsen, Christian Holmberg, Rita Slaaby
Publikováno v: Genes & Development. 19:853-862
The human UV-damaged DNA-binding protein Ddb1 associates with cullin 4 ubiquitin ligases implicated in nucleotide excision repair (NER). These complexes also contain the signalosome (CSN), but NER-relevant ubiquitination targets have not yet been ide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff17d173a7c7de34783a0889feb996a8
https://doi.org/10.1101/gad.329905
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10
Repair of Damaged and Mismatched DNA by the XPC Homologues Rhp41 and Rhp42 of Fission Yeast
Autor: Christophe Kunz, Oliver Fleck, Thomas M. Marti
Publikováno v: Scopus-Elsevier
Europe PubMed Central
Rhp41 and Rhp42 of Schizosaccharomyces pombe are homologues of human XPC, which is involved in nucleotide excision repair (NER) of damaged DNA. Inactivation of rhp41 caused moderate sensitivity to ultraviolet (UV) radiation. In addition, an increase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16ab7f01ed9ab33433e3af1b798442b
https://doi.org/10.1093/genetics/164.2.457
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