Zobrazeno 1 - 10
of 573
pro vyhledávání: '"Oliver D, Howes"'
Autor:
Leonardo Sportelli, Daniel P. Eisenberg, Roberta Passiatore, Enrico D’Ambrosio, Linda A. Antonucci, Jasmine S. Bettina, Qiang Chen, Aaron L. Goldman, Michael D. Gregory, Kira Griffiths, Thomas M. Hyde, Joel E. Kleinman, Antonio F. Pardiñas, Madhur Parihar, Teresa Popolizio, Antonio Rampino, Joo Heon Shin, Mattia Veronese, William S. Ulrich, Caroline F. Zink, Alessandro Bertolino, Oliver D. Howes, Karen F. Berman, Daniel R. Weinberger, Giulio Pergola
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decom
Externí odkaz:
https://doaj.org/article/bdf3671448254ff98814912fb8b64f61
Autor:
Ekaterina Shatalina, Thomas S. Whitehurst, Ellis Chika Onwordi, Barnabas J. Gilbert, Gaia Rizzo, Alex Whittington, Ayla Mansur, Hideo Tsukada, Tiago Reis Marques, Sridhar Natesan, Eugenii A. Rabiner, Matthew B. Wall, Oliver D. Howes
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Background Mitochondrial function plays a key role in regulating neurotransmission and may contribute to general intelligence. Mitochondrial complex I (MC-I) is the largest enzyme of the respiratory chain. Recently, it has become possible to
Externí odkaz:
https://doaj.org/article/fc9cc9db83404d56a6bdf9ac805e11dd
Autor:
Fiona J. Ramage, Spyridon Siafis, Edoardo G. Ostinelli, Virginia Chiocchia, Claire Stansfield, Simonne Wright, Ioannis Mantas, Damian Omari Juma, Grazia Rutigliano, Oliver D. Howes, Francesca Tinsdeall, Lea Milligan, Claire Friedrich, Julian H. Elliott, Carmen Moreno, Ava Homiar, James Thomas, Emily S. Sena, Malcolm R. Macleod, Charlotte Austin, Nobuyuki Nomura, Jaycee Kennett, Soraya Seedat, Luke J. Vano, Andrea Cipriani, Olena Maksym, Jennifer Potts, David Gilbert, Thomy Tonia, Robert A. McCutcheon, Matthias Egger, Stefan Leucht, Toshi A. Furukawa, Hossein Dehdarirad, Janna Hastings, Susan Michie, Georgia Salanti, Olufisayo Elugbadebo, Ouma Simple
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Background Trace amine-associated receptor 1 (TAAR1) agonism shows promise for treating psychosis, prompting us to synthesise data from human and non-human studies. Methods We co-produced a living systematic review of controlled studies examining TAA
Externí odkaz:
https://doaj.org/article/e35d8b7f971f47dfafe6169514abb7b4
Autor:
Uzma Zahid, Robert A. McCutcheon, Faith Borgan, Sameer Jauhar, Fiona Pepper, Matthew M. Nour, Maria Rogdaki, Martin Osugo, Graham K. Murray, Pamela Hathway, Robin M. Murray, Alice Egerton, Oliver D. Howes
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/a972f72c0e8346ab950623456976cfbe
Autor:
Oisín O'Brien, Atheeshaan Arumuham, Yuya Mizuno, Luke Baxter, Maria Lobo, Sita Parmar, Stephen Jolles, Oliver D. Howes
Publikováno v:
BJPsych Open, Vol 10 (2024)
This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccination programme. Prio
Externí odkaz:
https://doaj.org/article/bb87e891dc134850b7dbbad71af27c91
Autor:
Sameer Jauhar, Robert A. McCutcheon, Mattia Veronese, Faith Borgan, Matthew Nour, Maria Rogdaki, Fiona Pepper, James M. Stone, Alice Egerton, George Vamvakas, Federico Turkheimer, Philip K. McGuire, Oliver D. Howes
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorders. To date no study has measure
Externí odkaz:
https://doaj.org/article/8dd3d6e9caa94fe18290de30b46752d7
Autor:
Marco Solmi, Christoph U Correll, Catherine M Hill, Samuele Cortese, David S Baldwin, Samuel R Chamberlain, Jay Amin, Ruihua Hou, Oliver D Howes, Nathan TM Huneke, Matthew Garner, Julia MA Sinclair
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Introduction Given the high prevalence of mental health disorders and their significant socioeconomic burden, there is a need to develop improved treatments, and to evaluate them through placebo-controlled trials. However, the magnitude of the placeb
Externí odkaz:
https://doaj.org/article/a9d178034fed4dfa9095d0d8843cef12
Autor:
Anne Krogh Nøhr, Annika Forsingdal, Ida Moltke, Oliver D. Howes, Morana Vitezic, Anders Albrechtsen, Maria Dalby
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The genetic architecture of antidepressant response is poorly understood. Polygenic risk scores (PRS), exploration of placebo response and the use of sub-scales might provide insights. Here, we investigate the association between PRSs for re
Externí odkaz:
https://doaj.org/article/1ef5143e614e451f83ea81e64b2cbff3
Autor:
Stefan Leucht, Robert McCutcheon, Spyridon Siafis, Edoardo G. Ostinelli, Virginia Chiocchia, Claire Stansfield, Simonne Wright, Ioannis Mantas, Damian Omari Juma, Grazia Rutigliano, Oliver D. Howes, Francesca Tinsdeall, Fiona Ramage, Lea Milligan, Claire Friedrich, Julian H. Elliott, Carmen Moreno, James Thomas, Emily S. Sena, Malcolm R. Macleod, Georgia Salanti, Soraya Seedat, Andrea Cipriani, Jennifer Potts
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: There is an urgent need to develop more effective and safer antipsychotics beyond dopamine 2 receptor antagonists. An emerging and promising approach is TAAR1 agonism. Therefore, we will conduct a living systematic review and meta-analysi
Externí odkaz:
https://doaj.org/article/1224ed15609e40bf84dc412b53a90ae5
Autor:
Enrico D’Ambrosio, Giulio Pergola, Antonio F. Pardiñas, Tarik Dahoun, Mattia Veronese, Leonardo Sportelli, Paolo Taurisano, Kira Griffiths, Sameer Jauhar, Maria Rogdaki, Michael A. P. Bloomfield, Sean Froudist-Walsh, Ilaria Bonoldi, James T. R. Walters, Giuseppe Blasi, Alessandro Bertolino, Oliver D. Howes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The D2 dopamine receptor (D2R) is the primary site of the therapeutic action of antipsychotics and is involved in essential brain functions relevant to schizophrenia, such as attention, memory, motivation, and emotion processing. Moreover, t
Externí odkaz:
https://doaj.org/article/dbe39ccf3d614d2d8f15ab9ffca373c2