Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Oliver Burk"'
Autor:
Azam Rashidian, Enni-Kaisa Mustonen, Thales Kronenberger, Matthias Schwab, Oliver Burk, Stefan A. Laufer, Tatu Pantsar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3004-3018 (2022)
Pregnane X receptor (PXR) is a nuclear receptor with an essential role in regulating drug metabolism genes. While the mechanism of action for ligand-mediated PXR agonism is well-examined, its ligand-mediated inhibition or antagonism is poorly underst
Externí odkaz:
https://doaj.org/article/390d4c67451d49668c763e41795e9da7
Autor:
Steffen Hirte, Oliver Burk, Ammar Tahir, Matthias Schwab, Björn Windshügel, Johannes Kirchmair
Publikováno v:
Cells, Vol 11, Iss 8, p 1253 (2022)
The pregnane X receptor (PXR) regulates the metabolism of many xenobiotic and endobiotic substances. In consequence, PXR decreases the efficacy of many small-molecule drugs and induces drug-drug interactions. The prediction of PXR activators with the
Externí odkaz:
https://doaj.org/article/3f215194b85c435291d2b76239f6a0ad
Autor:
Enni-Kaisa Mustonen, Tatu Pantsar, Azam Rashidian, Juliander Reiner, Matthias Schwab, Stefan Laufer, Oliver Burk
Publikováno v:
Cells, Vol 11, Iss 8, p 1299 (2022)
Small-molecule protein kinase inhibitors are used for the treatment of cancer, but off-target effects hinder their clinical use. Especially off-target activation of the pregnane X receptor (PXR) has to be considered, as it not only governs drug metab
Externí odkaz:
https://doaj.org/article/03922f629772424eb174ca323172c458
Autor:
Andreas Bitter, Andreas K. Nüssler, Wolfgang E. Thasler, Kathrin Klein, Ulrich M. Zanger, Matthias Schwab, Oliver Burk
Publikováno v:
Cellular Physiology and Biochemistry, Vol 35, Iss 2, Pp 803-815 (2015)
Background/Aims: Sterol regulatory element-binding protein (SREBP) 1, the master regulator of lipogenesis, was shown to be associated with non-alcoholic fatty liver disease, which is attributed to its major isoform SREBP1c. Based on studies in mice,
Externí odkaz:
https://doaj.org/article/0758d4d4b300404b982e05ebd320b2d1
Autor:
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148703 (2016)
Externí odkaz:
https://doaj.org/article/443d23b05ac94fd29f0bd6d06ee95c65
Autor:
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96263 (2014)
The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics. While human an
Externí odkaz:
https://doaj.org/article/d82764fa8b804bb09265843d6ea49dba
Publikováno v:
ACS Omega, Vol 9, Iss 5, Pp 5517-5522 (2024)
Externí odkaz:
https://doaj.org/article/5ec4fd395b104e6681b0ec323ae4e5b4
Autor:
Oliver Burk, Wolfgang E. Thasler, Thomas S. Weiss, Judith Jeske, Matthias Schwab, Andreas Bitter
Publikováno v:
Biochemical Pharmacology. 136:122-135
Pregnane X receptor (PXR) mainly regulates xenobiotic metabolism and detoxification. Additionally, it exerts pleiotropic effects on liver physiology, which in large parts depend on transrepression of other liver-enriched transcription factors. Based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2e7b3c6ecbd8cbae82ab40889064ae
https://doi.org/10.1016/j.bcp.2017.04.013
https://doi.org/10.1016/j.bcp.2017.04.013
Publikováno v:
Archives of Toxicology. 91:2375-2390
Unintentional activation of xenosensing nuclear receptors pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR) by clinical drug use is known to produce severe side effects in patients, which may be overcome by co-administering anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cfa755c905fa2c84120e912560474f
https://doi.org/10.1007/s00204-017-1948-3
https://doi.org/10.1007/s00204-017-1948-3
Autor:
Serene M. L. Lee, Björn Windshügel, Tobias S. Schiergens, Frank Essmann, Oliver Burk, Matthias Schwab, Oliver Keminer
Publikováno v:
Archives of toxicology. 93(8)
Prediction of drug interactions, based on the induction of drug disposition, calls for the identification of chemicals, which activate xenosensing nuclear receptors. Constitutive androstane receptor (CAR) is one of the major human xenosensors; howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cf64a760ec49da327dcc0b17d34b81
https://pubmed.ncbi.nlm.nih.gov/31312845
https://pubmed.ncbi.nlm.nih.gov/31312845