Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Oliver Borst"'
Autor:
Tobias Harm, Xiaoqing Fu, Moritz Frey, Kristina Dittrich, Adrian Brun, Tatsiana Castor, Oliver Borst, Karin Anne Lydia Müller, Tobias Geisler, Dominik Rath, Michael Lämmerhofer, Meinrad Paul Gawaz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Coronary artery disease (CAD) often leads to adverse events resulting in significant disease burdens. Underlying risk factors often remain inapparent prior to disease incidence and the cardiovascular (CV) risk is not exclusively explained by
Externí odkaz:
https://doaj.org/article/93ab7b9776024ab59fb957d8bedb2885
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Formation of Neutrophil Extracellular Traps (NETosis), accompanied by the release of extracellular decondensed chromatin and pro-inflammatory as well as pro-thrombotic factors, is a pivotal element in the development and progression of thrombo-occlus
Externí odkaz:
https://doaj.org/article/98e922d278c949e29b62cd121fe9b379
Autor:
Anne-Katrin Rohlfing, Kyra Kolb, Manuel Sigle, Melanie Ziegler, Alexander Bild, Patrick Münzer, Jessica Sudmann, Valerie Dicenta, Tobias Harm, Mailin-Christin Manke, Sascha Geue, Marcel Kremser, Madhumita Chatterjee, Chunguang Liang, Hendrik von Eysmondt, Thomas Dandekar, David Heinzmann, Manina Günter, Saskia von Ungern-Sternberg, Manuela Büttcher, Tatsiana Castor, Stine Mencl, Friederike Langhauser, Katharina Sies, Diyaa Ashour, Mustafa Caglar Beker, Michael Lämmerhofer, Stella E. Autenrieth, Tilman E. Schäffer, Stefan Laufer, Paulina Szklanna, Patricia Maguire, Matthias Heikenwalder, Karin Anne Lydia Müller, Dirk M. Hermann, Ertugrul Kilic, Ralf Stumm, Gustavo Ramos, Christoph Kleinschnitz, Oliver Borst, Harald F. Langer, Dominik Rath, Meinrad Gawaz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
ACKR3 is a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Platelet ACKR3 surface expression is independently associated with all-cause mortality in patients with cardiovascular diseases.
Externí odkaz:
https://doaj.org/article/bff45f142b4844968bc8a69ceae8231a
Autor:
Clemens Hinterleitner, Jasmin Strähle, Elke Malenke, Martina Hinterleitner, Melanie Henning, Marco Seehawer, Tatjana Bilich, Jonas Heitmann, Martina Lutz, Sven Mattern, Sophia Scheuermann, Marius Horger, Stefanie Maurer, Juliane Walz, Falko Fend, Rupert Handgretinger, Christian Seitz, Bettina Weigelin, Stephan Singer, Helmut Salih, Oliver Borst, Hans-Georg Kopp, Lars Zender
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The definition of biomarkers to predict therapy responses to immune-checkpoint inhibitors represent an unmet clinical need. Here the authors provide evidences that platelet-derived PD-L1 could serve as a prognostic and predictive biomarker in patient
Externí odkaz:
https://doaj.org/article/667bac11196140cc814118dc5b22f2f3
Autor:
Henry Nording, Lasse Baron, David Haberthür, Frederic Emschermann, Matthias Mezger, Manuela Sauter, Reinhard Sauter, Johannes Patzelt, Kai Knoepp, Anne Nording, Moritz Meusel, Roza Meyer-Saraei, Ruslan Hlushchuk, Daniel Sedding, Oliver Borst, Ingo Eitel, Christian M. Karsten, Robert Feil, Bernd Pichler, Jeanette Erdmann, Admar Verschoor, Emmanouil Chavakis, Triantafyllos Chavakis, Philipp von Hundelshausen, Jörg Köhl, Meinrad Gawaz, Harald F. Langer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
As more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 s
Externí odkaz:
https://doaj.org/article/87faa2a159a0413296eadbb6d07bb8c0
Autor:
Bing Peng, Dominik Kopczynski, Brian S. Pratt, Christer S. Ejsing, Bo Burla, Martin Hermansson, Peter Imre Benke, Sock Hwee Tan, Mark Y. Chan, Federico Torta, Dominik Schwudke, Sven W. Meckelmann, Cristina Coman, Oliver J. Schmitz, Brendan MacLean, Mailin-Christin Manke, Oliver Borst, Markus R. Wenk, Nils Hoffmann, Robert Ahrends
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Targeted mass spectrometry enables reproducible and accurate lipid quantification but dedicated software tools to develop targeted lipidomics assays are lacking. Here, the authors develop a targeted lipidomics workbench and lipid knowledgebase for th
Externí odkaz:
https://doaj.org/article/cf125a979bd74b198ac9797a20846f29
Autor:
Tianyun Guan, Frederic Emschermann, Christoph Schories, Patrick Groga-Bada, Peter Martus, Oliver Borst, Meinrad Gawaz, Tobias Geisler, Dominik Rath, Madhumita Chatterjee
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11066 (2022)
Platelets express the transmembrane chemokine SR-PSOX/CXCL16, proteolytic cleavage of which generates the sCXCL16 soluble-(s) chemokine. The sCXCL16 engages CXCR6 on platelets to synergistically propagate degranulation, aggregation and thrombotic res
Externí odkaz:
https://doaj.org/article/93e8c76e6e6a45c3a47e2647fe436d62
Autor:
Patrick Münzer, Oliver Borst
Publikováno v:
Cells, Vol 11, Iss 4, p 619 (2022)
Thrombo-occlusive diseases such as myocardial infarction, ischemic stroke and deep vein thrombosis with subsequent pulmonary embolism still represent a major health burden worldwide. Besides the cells of the vasculature or other hematopoietic cells,
Externí odkaz:
https://doaj.org/article/51c3b15b20534ddfa2387ccf59790ae8
Autor:
Oliver Borst, Patrick Münzer, Nada Alnaggar, Sascha Geue, Roland Tegtmeyer, Dominik Rath, Michal Droppa, Peter Seizer, Stefan Heitmeier, Johan W.M. Heemskerk, Lisa K. Jennings, Robert F. Storey, Dominick J. Angiolillo, Bianca Rocca, Henri Spronk, Hugo Ten Cate, Meinrad Gawaz, Tobias Geisler
Publikováno v:
Blood Advances, Vol 2, Iss 6, Pp 715-730 (2018)
Abstract: Very low–dose (VLD) factor Xa (FXa) inhibition, in combination with acetylsalicylic acid (ASA) and clopidogrel, is associated with improved outcomes in patients with acute coronary syndrome (ACS) with a tolerable bleeding risk profile. To
Externí odkaz:
https://doaj.org/article/d9e3884a70ea426791e0641813794a24
Autor:
Jeremy A. Nestele, Anne-Katrin Rohlfing, Valerie Dicenta, Alexander Bild, Daniela Eißler, Frederic Emschermann, Marcel Kremser, Konstantin Krutzke, Tilman E. Schäffer, Oliver Borst, Moran Levi, Netanel Korin, Meinrad Paul Gawaz
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 11 (2021)
Traditional antithrombotic agents commonly share a therapy-limiting side effect, as they increase the overall systemic bleeding risk. A novel approach for targeted antithrombotic therapy is nanoparticles. In other therapeutic fields, nanoparticles ha
Externí odkaz:
https://doaj.org/article/9e07861e69874a309e3820f47d363fd4