Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Oliver B Davis"'
Autor:
Xiang Wang, Vitaliy V Bondar, Oliver B Davis, Michael T Maloney, Maayan Agam, Marcus Y Chin, Audrey Cheuk-Nga Ho, Rajarshi Ghosh, Dara E Leto, David Joy, Meredith EK Calvert, Joseph W Lewcock, Gilbert Di Paolo, Robert G Thorne, Zachary K Sweeney, Anastasia G Henry
Publikováno v:
eLife, Vol 12 (2023)
Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson’s disease (PD) and Crohn’s disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis includ
Externí odkaz:
https://doaj.org/article/1459c4b9a28a4c35be189566695ad7a3
Autor:
Vitaliy V. Bondar, Xiang Wang, Oliver B. Davis, Michael T. Maloney, Maayan Agam, Marcus Y. Chin, Audrey Cheuk-Nga Ho, David Joy, Joseph W. Lewcock, Gilbert Di Paolo, Robert G. Thorne, Zachary K. Sweeney, Anastasia G. Henry
Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson’s disease (PD) and Crohn’s disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e3b9441d471cebda4108d94643d132
https://doi.org/10.1101/2023.02.21.529466
https://doi.org/10.1101/2023.02.21.529466
Autor:
Michael T. Maloney, Xiang Wang, Rajarshi Ghosh, Shan V. Andrews, Romeo Maciuca, Shababa T. Masoud, Richard M. Caprioli, John Chen, Chi-Lu Chiu, Sonnet S. Davis, Audrey Cheuk-Nga Ho, Hoang N. Nguyen, Nicholas E. Propson, Michelle L. Reyzer, Oliver B. Davis, Matthew C. Deen, Sha Zhu, Gilbert Di Paolo, David J. Vocadlo, Anthony A. Estrada, Javier de Vicente, Joseph W. Lewcock, Annie Arguello, Jung H. Suh, Sarah Huntwork-Rodriguez, Anastasia G. Henry
Lysosomal dysfunction is a hallmark of Parkinson’s disease (PD), and variants in several PD-associated genes, includingLRRK2, perturb lysosomal homeostasis. Based on this, LRRK2 kinase inhibition is being explored as a therapeutic approach for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc13473cd36348881c86cb13ff023e4d
https://doi.org/10.1101/2022.12.19.521070
https://doi.org/10.1101/2022.12.19.521070
Autor:
Hijai R. Shin, Y. Rose Citron, Lei Wang, Laura Tribouillard, Claire S. Goul, Robin Stipp, Yusuke Sugasawa, Aakriti Jain, Nolwenn Samson, Chun-Yan Lim, Oliver B. Davis, David Castaneda-Carpio, Mingxing Qian, Daniel K. Nomura, Rushika M. Perera, Eunyong Park, Douglas F. Covey, Mathieu Laplante, Alex S. Evers, Roberto Zoncu
Publikováno v:
Science (New York, N.Y.), vol 377, iss 6612
Science
Science
Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified lysosomal cholesterol signaling (LYCHOS, previously annotated as G pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5679d35b76dd78baa098dc74865d1898
https://escholarship.org/uc/item/8g07j454
https://escholarship.org/uc/item/8g07j454
Autor:
Daniel K. Nomura, Roberto Zoncu, Hijai R. Shin, Xuntian Jiang, Justin Zhang, Charles A. Berdan, Daniel S. Ory, Oliver B. Davis, Chun Yan Lim, Jessica L. Counihan
Publikováno v:
Nature cell biology
Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases). The mechanisms that regulate lysosomal cholesterol content to enable mTORC1 sig
Autor:
Matthew Kukurugya, Emma Y. Wu, Hijai R. Shin, Oliver B. Davis, M. Paulina Ordonez, Chun-Yan Lim, Claire F. Maher, Roberto Zoncu, Rushika M. Perera
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal chol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce7b50644313b1e5d6e5f4ee901f8995
https://doi.org/10.1101/2020.08.02.233254
https://doi.org/10.1101/2020.08.02.233254
Autor:
M. Paulina Ordonez, Oliver B. Davis, Roberto Zoncu, Claire F. Maher, Hijai R. Shin, Chun-Yan Lim, Emma Y. Wu, Matthew Kukurugya, Rushika M. Perera
Publikováno v:
Developmental cell. 56(3)
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal chol
Autor:
Oliver B. Davis, Edoardo Nusco, Roberto Zoncu, Chiara Di Malta, Angela Zampelli, Margret H. Ogmundsdottir, Carmine Settembre, Rossella De Cegli, Andrea N. Eastes, Nunzia Pastore, Alessandro Guida, Diletta Siciliano, Andrea Ballabio, Luca Giovanni Di Giovannantonio, Pier Giuseppe Pelicci, Simona Punzi, Rushika M. Perera, Alessia Calcagni, Luisa Lanfrancone, Jlenia Monfregola, Nick Platt
Publikováno v:
Science (N. Y., N.Y.) 356 (2017): 1188–1192. doi:10.1126/science.aag2553
info:cnr-pdr/source/autori:Di Malta, Chiara; Siciliano, Diletta; Calcagni, Alessia; Monfregola, Jlenia; Punzi, Simona; Pastore, Nunzia; Eastes, Andrea N.; Davis, Oliver; De Cegli, Rossella; Zampelli, Angela; Di Giovannantonio, Luca G.; Nusco, Edoardo; Platt, Nick; Guida, Alessandro; Ogmundsdottir, Margret Helga; Lanfrancone, Luisa; Perera, Rushika M.; Zoncu, Roberto; Pelicci, Pier Giuseppe; Settembre, Carmine; Ballabio, Andrea/titolo:Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth/doi:10.1126%2Fscience.aag2553/rivista:Science (N. Y., N.Y.)/anno:2017/pagina_da:1188/pagina_a:1192/intervallo_pagine:1188–1192/volume:356
Science (New York, N.Y.), vol 356, iss 6343
Science
Cell Stress
info:cnr-pdr/source/autori:Di Malta, Chiara; Siciliano, Diletta; Calcagni, Alessia; Monfregola, Jlenia; Punzi, Simona; Pastore, Nunzia; Eastes, Andrea N.; Davis, Oliver; De Cegli, Rossella; Zampelli, Angela; Di Giovannantonio, Luca G.; Nusco, Edoardo; Platt, Nick; Guida, Alessandro; Ogmundsdottir, Margret Helga; Lanfrancone, Luisa; Perera, Rushika M.; Zoncu, Roberto; Pelicci, Pier Giuseppe; Settembre, Carmine; Ballabio, Andrea/titolo:Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth/doi:10.1126%2Fscience.aag2553/rivista:Science (N. Y., N.Y.)/anno:2017/pagina_da:1188/pagina_a:1192/intervallo_pagine:1188–1192/volume:356
Science (New York, N.Y.), vol 356, iss 6343
Science
Cell Stress
The mechanistic target of rapamycin complex 1 (mTORC1) is recruited to the lysosome by Rag guanosine triphosphatases (GTPases) and regulates anabolic pathways in response to nutrients. We found that MiT/TFE transcription factors—master regulators o
Autor:
Xuntian Jiang, Roberto Zoncu, Daniel K. Nomura, Ofer Moldavski, Laurel Mydock-McGrane, Daniel S. Ory, McKenna Feltes, Oliver B. Davis, Robert J. van Eijkeren, Rushika M. Perera, Brian M. Castellano, Sharon M. Louie, Douglas F. Covey, Ashley M. Thelen, Reini E. N. van der Welle
Publikováno v:
Science (New York, N.Y.), vol 355, iss 6331
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to nutrient cues. Here, we identify cholesterol, an essential building block for cellular growth, as
Autor:
Mary Carrington, Bruce D. Walker, Damien Z. Soghoian, Daniel Karel, Carl M. Kadie, Oliver B. Davis, Ariel Goldenthal, Alicja Piechocka, Jian Peng, David Heckerman, Jonathan M. Carlson, Florencia Pereyra, Tien-Ho Lin, Charles E. DeZiel
Publikováno v:
Journal of Virology. 88:12937-12948
We investigated the hypothesis that the correlation between the class I HLA types of an individual and whether that individual spontaneously controls HIV-1 is mediated by the targeting of specific epitopes by CD8 + T cells. By measuring gamma interfe