Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Oliver, Wirths"'
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background STAT1 is an intracellular signaling molecule that is crucially involved in the regulation of the innate immune system by activation of defense mechanisms against microbial pathogens. Phosphorylation-dependent activation of the STA
Externí odkaz:
https://doaj.org/article/65d7b0b077bd42f48f145c6de6a94af1
Autor:
Hans-Wolfgang Klafki, Barbara Morgado, Oliver Wirths, Olaf Jahn, Chris Bauer, Hermann Esselmann, Johannes Schuchhardt, Jens Wiltfang
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background A reduced amyloid-β (Aβ)42/40 peptide ratio in blood plasma represents a peripheral biomarker of the cerebral amyloid pathology observed in Alzheimer’s disease brains. The magnitude of the measurable effect in plasma is smalle
Externí odkaz:
https://doaj.org/article/8ae8035bbb0640a297283a15a40c607b
Autor:
Lena Sophie Behrendsen, Priyanka Rajeev Menon, Muhammad Jawad Khan, Anke Gregus, Oliver Wirths, Thomas Meyer, Julia Staab
Publikováno v:
BMC Molecular and Cell Biology, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that promotes cell proliferation and immunomodulation in untransformed cells and maintains stemness of transformed cells, facilitating
Externí odkaz:
https://doaj.org/article/22ad33cd6e5a4e95937739b42cec51d3
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Unphosphorylated signal transducer and activator of transcription 1 (U-STAT1) has been reported to elicit a distinct gene expression profile as compared to tyrosine-phosphorylated STAT1 (P-STAT1) homodimers. However, the impact of
Externí odkaz:
https://doaj.org/article/616275c055264bdfbdc779cfddf93301
Autor:
Asmma Doudin, Theresa Riebeling, Julia Staab, Priyanka Rajeev Menon, Fred Lühder, Oliver Wirths, Uwe Vinkemeier, Aleksandar Ivetic, Thomas Meyer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
In this study, we addressed the functional significance of co-operative DNA binding of the cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) in an experimental murine model of acute myocardial infarction
Externí odkaz:
https://doaj.org/article/6e99cd63699844a09ecde075a375803b
Autor:
Matthias Kettwig, Katharina Ternka, Kristin Wendland, Dennis Manfred Krüger, Silvia Zampar, Charlotte Schob, Jonas Franz, Abhishek Aich, Anne Winkler, M. Sadman Sakib, Lalit Kaurani, Robert Epple, Hauke B. Werner, Samy Hakroush, Julia Kitz, Marco Prinz, Eva Bartok, Gunther Hartmann, Simone Schröder, Peter Rehling, Marco Henneke, Susann Boretius, A. Alia, Oliver Wirths, Andre Fischer, Christine Stadelmann, Stefan Nessler, Jutta Gärtner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.
Externí odkaz:
https://doaj.org/article/bd1fa646273840d68762f26fc8a37047
Autor:
Md Rezaul Islam, Lalit Kaurani, Tea Berulava, Urs Heilbronner, Monika Budde, Tonatiuh Pena Centeno, Vakthang Elerdashvili, Maria‐Patapia Zafieriou, Eva Benito, Sinem M Sertel, Maria Goldberg, Fanny Senner, Janos L Kalman, Susanne Burkhardt, Anne Sophie Oepen, Mohammad Sadman Sakib, Cemil Kerimoglu, Oliver Wirths, Heike Bickeböller, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Nicoleta‐Carmen Cosma, Klaus Fliessbach, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Luca Kleinedam, Christoph Laske, Coraline D Metzger, Matthias H Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris S. Rauchmann, Nina Roy, Anja Schneider, Annika Spottke, Eike J Spruth, Stefan Teipel, Maike Tscheuschler, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Delcode Study Group, Silvio O Rizzoli, Wolfram‐Hubertus Zimmermann, Thomas G Schulze, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-28 (2021)
Abstract While some individuals age without pathological memory impairments, others develop age‐associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced s
Externí odkaz:
https://doaj.org/article/1e2ab5f4a61e40db8cbade9a85f5dc94
Autor:
Freyja Aichholzer, Hans-Wolfgang Klafki, Isabella Ogorek, Jonathan Vogelgsang, Jens Wiltfang, Norbert Scherbaum, Sascha Weggen, Oliver Wirths
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder associated with extracellular amyloid-β peptide deposition and progressive neuron loss. Strong evidence supports that neuroinflammatory changes such as the activation of
Externí odkaz:
https://doaj.org/article/05f6d351f5384f2c95c03641b6682c2e
Autor:
Angelika Sabine Bader, Marius-Uwe Gnädig, Merle Fricke, Luca Büschgens, Lena Josefine Berger, Hans-Wolfgang Klafki, Thomas Meyer, Olaf Jahn, Sascha Weggen, Oliver Wirths
Publikováno v:
Life, Vol 13, Iss 4, p 1053 (2023)
Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are often con
Externí odkaz:
https://doaj.org/article/68237a998a89417498e77aaeb7a0356f
Autor:
Thomas Liepold, Hans-Wolfgang Klafki, Sathish Kumar, Jochen Walter, Oliver Wirths, Jens Wiltfang, Olaf Jahn
Publikováno v:
Journal of the American Society for Mass Spectrometry
Amyloid-β (Aβ) peptides, including post-translationally modified variants thereof, are believed to play a key role in the onset and progression of Alzheimer’s disease. Suggested modified Aβ species with potential disease relevance include Aβ pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1e465a2253853ca072c4784c3055fe
https://doi.org/10.1021/jasms.2c00270
https://doi.org/10.1021/jasms.2c00270