Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Oliver, Simic"'
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Oliver Simic, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a v
Externí odkaz:
https://doaj.org/article/d64305878b7f4abe9dd92a3040e7b4f4
Autor:
Marc Bigaud, Achim Schlapbach, Ina Dix, Ralf Endres, Jean Quancard, Jutta Blank, Frédéric Bornancin, Markus Wartmann, Julien Scesa, Paulo Antonio Fernandes Gomes Dos Santos, Eva Altmann, Thomas Radimerski, Guido Bold, Nicole Buschmann, Samu Melkko, Andreas Weiss, Paul W. Manley, P. Erbel, Oliver Simic, Thomas Zoller, Catherine H. Régnier, Ansgar Schuffenhauer, Elisabeth Buchdunger, Martin Renatus, Paul M.J. McSheehy, Carole Pissot Soldermann
Publikováno v:
Journal of Medicinal Chemistry. 63:14576-14593
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9969a4c36550186a210fdfae8c1af415
https://doi.org/10.1021/acs.jmedchem.0c01245
https://doi.org/10.1021/acs.jmedchem.0c01245
Autor:
Jean Quancard, Laurence Kieffer, Samu Melkko, Ralf Endres, Martin Renatus, Catherine H. Régnier, Thomas Calzascia, Mickael Sorge, Markus Wartmann, Frédéric Bornancin, Thomas Radimerski, P. Erbel, Carole Pissot Soldermann, Paul M.J. McSheehy, Markus Blatter, Reiner Aichholz, Trixie Wagner, Oliver Simic, Karen Beltz, Marc Bigaud, Achim Schlapbach, Andreas Weiss
Publikováno v:
Journal of Medicinal Chemistry. 63:14594-14608
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a7c1ce6f98fa56490d44e94ead5daa
https://doi.org/10.1021/acs.jmedchem.0c01246
https://doi.org/10.1021/acs.jmedchem.0c01246
In vivo imaging with fluorescent smart probes to assess treatment strategies for acute pancreatitis.
Autor:
Abhiruchi Agarwal, Andreas Boettcher, Rainer Kneuer, Farid Sari-Sarraf, Adriana Donovan, Julian Woelcke, Oliver Simic, Trixi Brandl, Thomas Krucker
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55959 (2013)
BACKGROUND AND AIMS: Endoprotease activation is a key step in acute pancreatitis and early inhibition of these enzymes may protect from organ damage. In vivo models commonly used to evaluate protease inhibitors require animal sacrifice and therefore
Externí odkaz:
https://doaj.org/article/685a8db557fa415b8d07c6ac5aa241bb
Autor:
Abhiruchi Agarwal, Andreas Boettcher, Rainer Kneuer, Farid Sari-Sarraf, Adriana Donovan, Julian Woelcke, Oliver Simic, Trixi Brandl, Thomas Krucker
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/2cf0564e4d7e42d9aa43d1aeb843175c
Autor:
Carole, Pissot Soldermann, Oliver, Simic, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Markus, Wartmann, Marc, Bigaud, Andreas, Weiss, Paul, McSheehy, Ralf, Endres, Paulo, Santos, Jutta, Blank, Ansgar, Schuffenhauer, Guido, Bold, Nicole, Buschmann, Thomas, Zoller, Eva, Altmann, Paul W, Manley, Ina, Dix, Elisabeth, Buchdunger, Julien, Scesa, Jean, Quancard, Achim, Schlapbach, Frédéric, Bornancin, Thomas, Radimerski, Catherine H, Régnier
Publikováno v:
Journal of medicinal chemistry. 63(23)
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c9148f487b1a8d48b0cb731fa2d9337
https://pubmed.ncbi.nlm.nih.gov/33252239
https://pubmed.ncbi.nlm.nih.gov/33252239
Autor:
Jean, Quancard, Oliver, Simic, Carole, Pissot Soldermann, Reiner, Aichholz, Markus, Blatter, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Ralf, Endres, Mickael, Sorge, Laurence, Kieffer, Trixie, Wagner, Karen, Beltz, Paul, Mcsheehy, Markus, Wartmann, Catherine H, Régnier, Thomas, Calzascia, Thomas, Radimerski, Marc, Bigaud, Andreas, Weiss, Frédéric, Bornancin, Achim, Schlapbach
Publikováno v:
Journal of medicinal chemistry. 63(23)
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95563fb4dabe5dbc98d44b011542ecbe
https://pubmed.ncbi.nlm.nih.gov/33216547
https://pubmed.ncbi.nlm.nih.gov/33216547
Autor:
Trixi Brandl, Kenji Namoto, Frederic Berst, Irene Mueller, Philip R. Skaanderup, Julian Woelcke, Oliver Simic, Nikolaus Schiering, Claus Ehrhardt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4340-4344
Proline-based trypsin inhibitors occupying the S1–S2–S1′ region were identified by an HTS screening campaign. It was discovered that truncation of the P1′ moiety and appropriate extension into the S4 region led to highly potent trypsin inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c806510bb4450a4149c9382a68556a5c
https://doi.org/10.1016/j.bmcl.2016.07.029
https://doi.org/10.1016/j.bmcl.2016.07.029
Autor:
Arnaud Decock, Paul Erbel, Mickael Sorge, Rene Beerli, Samu Melkko, Frédéric Bornancin, Bertran Rubi, Oliver Simic, Catherine H. Régnier, Carole Pissot-Soldermann, Martin Renatus, Jean Quancard, Achim Schlapbach, Langlois Jean Baptiste Georges Armand, Nikolaus Schiering, Nicola Hughes, Marina Tintelnot-Blomley, Karen Beltz, Frederic Villard, Nicole Buschmann, Carsten Spanka, Christian Wiesmann
Publikováno v:
Advanced Therapeutics. 3:2000078
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b9fc30252a7312c68632b24ac2bde3
https://doi.org/10.1002/adtp.202000078
https://doi.org/10.1002/adtp.202000078
N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity
Autor:
Markus Wartmann, Ralf Endres, Jean Quancard, Richard Heng, Laszlo Revesz, Frédéric Bornancin, Samu Melkko, Achim Schlapbach, Catherine H. Régnier, Martin Renatus, Carole Pissot Soldermann, Oliver Simic, Ansgar Schuffenhauer, P. Erbel, Thomas Zoller, Jutta Blank, Thomas Radimerski
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(12)
Starting from a weak screening hit, potent and selective inhibitors of the MALT1 protease function were elaborated. Advanced compounds displayed high potency in biochemical and cellular assays. Compounds showed activity in a mechanistic Jurkat T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa85635c6f805b72497f660fe9f5dcbb
https://pubmed.ncbi.nlm.nih.gov/29759726
https://pubmed.ncbi.nlm.nih.gov/29759726