Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Oliver, Politz"'
Autor:
Tatsuo Sugawara, Ekaterina Nevedomskaya, Simon Heller, Annika Böhme, Ralf Lesche, Oliver vonAhsen, Sylvia Grünewald, Holly M. Nguyen, Eva Corey, Simon J. Baumgart, Victoria Georgi, Vera Pütter, Amaury Fernández‐Montalván, James D. Vasta, Matthew B. Robers, Oliver Politz, Dominik Mumberg, Bernard Haendler
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 726-742 (2024)
Prostate cancer is a frequent malignancy in older men and has a very high 5‐year survival rate if diagnosed early. The prognosis is much less promising if the tumor has already spread outside the prostate gland. Targeted treatments mainly aim at bl
Externí odkaz:
https://doaj.org/article/d4cfe16cad13404788f8437fa5048036
Autor:
César Serrano, Oliver Politz, Joaquín Arribas, Jonathan A. Fletcher, Paolo Nuciforo, Joan Carles, Claudia Valverde, Garazi Serna, Jordi Rosell, Alfonso García-Valverde
Number of mice per treatment arm at baseline used for in vivo experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1c88511379de9b4fafeaaa90dd5b5f
https://doi.org/10.1158/1535-7163.22520817.v1
https://doi.org/10.1158/1535-7163.22520817.v1
Autor:
César Serrano, Oliver Politz, Joaquín Arribas, Jonathan A. Fletcher, Paolo Nuciforo, Joan Carles, Claudia Valverde, Garazi Serna, Jordi Rosell, Alfonso García-Valverde
KIT or PDGFRA gain-of-function mutations are the primary drivers of gastrointestinal stromal tumor (GIST) growth and progression throughout the disease course. The PI3K/mTOR pathway is critically involved in the transduction of KIT/PDGFRA oncogenic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3915279d708e3bd12a8d2c0dc421c1be
https://doi.org/10.1158/1535-7163.c.6542790
https://doi.org/10.1158/1535-7163.c.6542790
Autor:
César Serrano, Oliver Politz, Joaquín Arribas, Jonathan A. Fletcher, Paolo Nuciforo, Joan Carles, Claudia Valverde, Garazi Serna, Jordi Rosell, Alfonso García-Valverde
Plasma levels of copanlisib of GIST-T1 and GIST-T1/670 xenografts at day 21. Plasma was collected 4 hours after last drug administration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057d484fc4044fbdd662405436c3a975
https://doi.org/10.1158/1535-7163.22520826
https://doi.org/10.1158/1535-7163.22520826
Autor:
Giulio Sartori, Chiara Tarantelli, Filippo Spriano, Eugenio Gaudio, Luciano Cascione, Michele Mascia, Marilia Barreca, Alberto J. Arribas, Luca Licenziato, Gaetanina Golino, Adele Ferragamo, Stefano Pileri, Giovanna Damia, Emanuele Zucca, Anastasios Stathis, Oliver Politz, Antje M. Wengner, Francesco Bertoni
PurposeThe DNA damage response (DDR) is the cellular process devoted to the preservation of an intact genome. The DDR is often deregulated in lymphoma cells due to high levels of DNA damage, tumor suppressor inactivation, increased replication stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d5fa43dad77dcbd07ab351243dfb2f
https://doi.org/10.1101/2023.02.10.528011
https://doi.org/10.1101/2023.02.10.528011
Autor:
Ulrich Keller, Andreas E. Albers, Raik Otto, Jan-Dirk Raguse, Jens Hoffmann, Theresa Eder, Konrad Klinghammer, Andreas M. Kaufmann, Ulrich Keilholz, Ingeborg Tinhofer, Oliver Politz
Publikováno v:
Oncotarget
Despite recent advances, the treatment of head and neck squamous cell carcinoma (HNSCC) remains an area of high unmet medical need. HNSCC is frequently associated with either amplification or mutational changes in the PI3K pathway, making PI3K an att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d845b638844f2322a1f8bbde92a6d5
http://europepmc.org/articles/PMC7566806
http://europepmc.org/articles/PMC7566806
Autor:
Chee Leong Cheng, Jing Quan Lim, Choon Kiat Ong, Wan-Lu Pang, Yurike Laurensia, Maarja-Liisa Nairismagi, Jing Tan, Tiffany Tang, Nagavalli Somasundaram, Giovani Giovani-Clarest Wijaya, Tammy Song, Ningshu Liu, Esther Kam Yin Wong, Burton Kuan Hui Chia, Soon Thye Lim, Jason Yongsheng Chan, Dachuan Huang, Oliver Politz, Sze Huey Tan, Daryl Cheah Ming Zhe
Publikováno v:
British Journal of Haematology
Summary Peripheral T‐cell lymphomas (PTCL) and natural killer (NK)/T‐cell lymphomas (NKTCL) are a heterogeneous group of aggressive malignancies with dismal outcomes and limited treatment options. While the phosphatidylinositol 3‐kinase (PIK3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6a30b2e18a0a62cb0dccfca95bb488
http://europepmc.org/articles/PMC7322801
http://europepmc.org/articles/PMC7322801
Publikováno v:
International Journal of Molecular Sciences. 24:2289
The reduction in androgen synthesis and the blockade of the androgen receptor (AR) function by chemical castration and AR signaling inhibitors represent the main treatment lines for the initial stages of prostate cancer. Unfortunately, resistance mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::190989bcdfb001d0b4e145f1722b470c
https://doi.org/10.3390/ijms24032289
https://doi.org/10.3390/ijms24032289
Autor:
Holger Hess-Stumpp, Marie-Pierre Collin, Stuart Ince, Oliver Politz, Uwe Thuss, Sebastian Bender, Klemens Lustig, Dieter Zopf, Christoph Kneip, Peter Ellinghaus, Dominik Mumberg, Sylvia Grünewald, Ulf Boemer, Charlotte Kopitz, Mélanie Héroult, Karl Ziegelbauer
Publikováno v:
International Journal of Cancer
Aberrant activation in fibroblast growth factor signaling has been implicated in the development of various cancers, including squamous cell lung cancer, squamous cell head and neck carcinoma, colorectal and bladder cancer. Thus, fibroblast growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b248e95ce00f38e560a438cac15a23
https://doi.org/10.1002/ijc.32224
https://doi.org/10.1002/ijc.32224
Autor:
Tatsuo Sugawara, Holly NGuyen, Eva Corey, Ekaterina Nevedomskaya, Oliver Politz, Dominik Mumberg, Bernard Haendler
Publikováno v:
Cancer Research. 82:651-651
Prostate cancer is mainly driven by androgen receptor (AR) signaling so that drugs directly inhibiting this pathway such as GnRH ligands and AR inhibitors are now established as mainstay treatments. Unfortunately, treatment resistance often develops
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16aba4f051df93eff69cbff300d5acdd
https://doi.org/10.1158/1538-7445.am2022-651
https://doi.org/10.1158/1538-7445.am2022-651