Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Oliver, Einsle"'
Autor:
Lorenz Heidinger, Kathryn Perez, Thomas Spatzal, Oliver Einsle, Stefan Weber, Douglas C. Rees, Erik Schleicher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Due to the complexity of the catalytic FeMo cofactor site in nitrogenases that mediates the reduction of molecular nitrogen to ammonium, mechanistic details of this reaction remain under debate. In this study, selenium- and sulfur-incorporat
Externí odkaz:
https://doaj.org/article/3533319ff4c04865b13a91688453b6fa
Autor:
Sheng Wang, Sebastian O. Klein, Sylvia Urban, Maximilian Staudt, Nicolas P. F. Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A. Rennar, Christian Gratzke, Katrin M. Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G. Thomson, Manfred Jung, Eric Metzger, Roland Schüle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Inhibition of epigenetic regulators by small molecules is an attractive strategy for cancer treatment. Recently, we characterised the role of lysine methyltransferase 9 (KMT9) in prostate, lung, and colon cancer. Our observation that the enz
Externí odkaz:
https://doaj.org/article/dd0315952e94463cb2a9a88ac996f944
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Mono- and multiheme cytochromes c are post-translationally matured by the covalent attachment of heme. For this, Escherichia coli employs the most complex type of maturation machineries, the Ccm-system (for cytochrome c maturation). It consi
Externí odkaz:
https://doaj.org/article/9b48aaf891444375adde52747b35de59
Autor:
Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J. Leng, Jingfan Zhang, Jing Zhu, Joe A. Kaczmarski, Ralf B. Schittenhelm, Oliver Einsle, Colin J. Jackson, Fabrizio Alberti, Andreas Bechthold, Youming Zhang, Manuela Tosin, Tong Si, Max J. Cryle
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3561-3574 (2023)
WS9326A is a peptide antibiotic containing a highly unusual N-methyl-E-2-3-dehydrotyrosine (NMet-Dht) residue that is incorporated during peptide assembly on a non-ribosomal peptide synthetase (NRPS). The cytochrome P450 encoded by sas16 (P450Sas) ha
Externí odkaz:
https://doaj.org/article/7d63ec27ecab4b6da2493ecc0f966b70
Autor:
Nadine Hellmold, Marie Eberwein, My Hanh Thi Phan, Steffen Kümmel, Oliver Einsle, Darja Deobald, Lorenz Adrian
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Proton translocation across the cytoplasmic membrane is a vital process for all organisms. Dehalococcoides strains are strictly anaerobic organohalide respiring bacteria that lack quinones and cytochromes but express a large membrane-bound protein co
Externí odkaz:
https://doaj.org/article/3e6c069228254cd4ad86cee3f3c9e150
Autor:
Pilar C. Portela, Leonor Morgado, Marta A. Silva, Lukas Denkhaus, Oliver Einsle, Carlos A. Salgueiro
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The recent reclassification of the strict anaerobe Geobacter sulfurreducens bacterium as aerotolerant brought attention for oxidative stress protection pathways. Although the electron transfer pathways for oxygen detoxification are not well establish
Externí odkaz:
https://doaj.org/article/ff779811f16f4a3186b902fec37aee36
Autor:
Chao Su, Marta Rodriguez-Franco, Beatrice Lace, Nils Nebel, Casandra Hernandez-Reyes, Pengbo Liang, Eija Schulze, Evgeny V. Mymrikov, Nikolas M. Gross, Julian Knerr, Hong Wang, Lina Siukstaite, Jean Keller, Cyril Libourel, Alexandra A. M. Fischer, Katharina E. Gabor, Eric Mark, Claudia Popp, Carola Hunte, Wilfried Weber, Petra Wendler, Thomas Stanislas, Pierre-Marc Delaux, Oliver Einsle, Robert Grosse, Winfried Römer, Thomas Ott
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
In plants, plasma membrane topologies are predominantly driven by the cell wall. In this study, the authors demonstrate that remorin proteins can take over these functions at specialized, unwalled plasma membranes such as infection droplets associate
Externí odkaz:
https://doaj.org/article/c0bfb6f46faf4340a3db7b4eb63fdce2
Autor:
Oliver Einsle
Publikováno v:
Molecules, Vol 28, Iss 24, p 7959 (2023)
Only a single enzyme system—nitrogenase—carries out the conversion of atmospheric N2 into bioavailable ammonium, an essential prerequisite for all organismic life. The reduction of this inert substrate at ambient conditions poses unique catalytic
Externí odkaz:
https://doaj.org/article/226a56e760c043bfb713bff6de551945
Autor:
Ana Pérez-González, Emilio Jimenez-Vicente, Jakob Gies-Elterlein, Alvaro Salinero-Lanzarote, Zhi-Yong Yang, Oliver Einsle, Lance C. Seefeldt, Dennis R. Dean
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The nitrogen-fixing microbe Azotobacter vinelandii has the ability to produce three genetically distinct, but mechanistically similar, components that catalyze nitrogen fixation. For two of these components, the Mo-dependent and V-dependent
Externí odkaz:
https://doaj.org/article/13ca6f06fc824a828cce68b7cf973176
Publikováno v:
Nature Catalysis. 6:415-424